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| Product | Description | |
|---|---|---|
| KYP-2047 | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| KYP-2047 | KYP-2047 is a selective Prolyl oligopeptidase inhibitor. And it is also known as prolyl endopeptidase. KYP-2047 can reduce α-synuclein protein levels and aggregate in cellular and animal models of Parkinson's disease. KYP-2047 can clear the α-synuclein aggregates induced by oxidative stress in the neuronal cells. Uses: Parkinson's disease. Synonyms: KYP-2047; KYP2047; KYP 2047. (2S)-1-[[(2S)-1-(1-Oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile. Grades: 95%. CAS No. 796874-99-2. Molecular formula: C20H25N3O2. Mole weight: 339.43. |  |
| Prolyl Endopeptidase Inhibitor III, KYP-2047 ((S)-1-((S)-1-(4-phenylbutanoyl)-pyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile, 4-phenylbutanoyl-Lprolyl-2(S)-cyanopyrrolidine, PREP Inhibitor III, KYP-2047) | A cell-permeable, potent, fast-acting, and selective inhibitor of prolyl oligopeptidase (PREP) (Ki = 23 pM). Reported to cross the blood-brain barrier. Inhibits about 85% PREP activity within 10 minutes of administration and exhibits a half-life of about 4.8h. Exhibits higher lipophilicity that increases its penetration across biological membranes in vivo. Maximum plasma and brain levels are achieved within 10 minutes following its i.p. administration. Shown to block oxidative-stress induced alpha-synuclein aggregation and clearance in cellular and animal models of Parkinson's disease. Also shown to improve cognitive performance in young rats (1-5mg/kg) in a dose-dependent manner. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. |  Worldwide |
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