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| Product | Description | |
|---|---|---|
| L-2-Hydroxyglutaric acid | L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation [1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase ( Mi-CK ) activity with K m and K i of 2.52 mM and 11.13 mM, respectively [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (S)-2-Hydroxyglutaric acid. CAS No. 13095-48-2. Pack Sizes: 5 mg (67.52 mM * 0.5 mL in Ethanol); 10 mg (67.52 mM * 1 mL in Ethanol). Product ID: HY-113039. |  |
| L-2-Hydroxyglutaric Acid | L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 13095-48-2. Molecular formula: C5H8O5. Mole weight: 148.11. Product ID: ACM13095482. Alfa Chemistry ISO 9001:2015 Certified. Categories: (2S)-2-hydroxypentanedioic acid, L-2-hydroxyglutaric aciduria. |  |
| L-2-Hydroxyglutaric acid disodium | L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation [1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase ( Mi-CK ) activity with K m and K i of 2.52 mM and 11.13 mM, respectively [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (S)-2-Hydroxyglutaric acid disodium. CAS No. 63512-50-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-W015114. | |
| (2S)-2-Hydroxyglutaric Acid Disodium Salt | A potential inhibitor of glutamate carboxypeptidase. Group: Biochemicals. Alternative Names: (2S)-2-Hydroxypentanedioic Acid; L-2-Hydroxyglutaric Acid Disodium Salt; (S)-α-Hydroxyglutaric Acid Disodium Salt; L-2-Hydroxyglutarate Disodium Salt. Grades: Highly Purified. CAS No. 63512-50-5. Pack Sizes: 25mg. US Biological Life Sciences. |  Worldwide |
| (2S)-2-Hydroxyglutaric Acid Benzyl Octyl Diester | (2S)-2-Hydroxyglutaric Acid Benzyl Octyl Diester is the benzyl, octyl diester derivative of (2S)-2-Hydroxyglutaric Acid (H942570), the potential inhibitor of glutamate carboxypeptidase. Group: Biochemicals. Alternative Names: Octyl L-2-Hydroxyglutarate Benzyl Ester. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| D-2-Hydroxyglutarate Dehydrogenase from Acidaminococcus fermentans, Recombinant | D-2-hydroxyglutarate (D2HG) level is significantly increased in metabolic diseases and various cancers such as acute myeloid leukemia. Studies suggest that the detection of D2HG serves as a biomarker assay related to IDH (isocitrate dehydrogenase) mutations. D2HGDH is a special NAD-dependent enzyme which reacts with D2HG specifically and converts D2HG to α-ketoglutarate. D2HGDH is a key enzyme to distinguish between two metabolites, D2HG and L-2-hydroxyglutarate (L2HG), during biomarker assays. Group: Enzymes. Synonyms: D-2-hydroxyglutarate dehydrogenase; D2HGDH; D2HGD. Enzyme Commission Number: EC 1.1.99.39. Purity: > 99% by SDS - PAGE. Mole weight: 39 kDa. Activity: > 90,000 mU/mg. Storage: Can be stored at 4°C up to 2 weeks. For long term storage, aliquot and store at -20°C. Avoid repeated freezing and thawing cycles. Form: Lyophilized in 50mM Tris, pH 8 without any additives. Source: E. coli. Species: Acidaminococcus fermentans. D-2-hydroxyglutarate dehydrogenase; D2HGDH; D2HGD. Cat No: NATE-1660. |  |
| phosphoglycerate dehydrogenase | This enzyme catalyses the first committed step in the phosphoserine pathway of serine biosynthesis in Escherichia coli. Reaction (1) occurs predominantly in the reverse direction and is inhibited by serine and glycine. The enzyme is unusual in that it also acts as a D- and L-2-hydroxyglutarate dehydrogenase (with the D-form being the better substrate) and as a 2-oxoglutarate reductase. It has been postulated that the cellular 2-oxoglutarate concentration may regulate serine biosynthesis and one-carbon metabolism directly by modulating the activity of this enzyme. Group: Enzymes. Synonyms: D-3-phosphoglycerate:NAD+ oxidoreductase; . Enzyme Commission Number: EC 1.1.1.95. CAS No. 9075-29-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0379; phosphoglycerate dehydrogenase; EC 1.1.1.95; 9075-29-0; D-3-phosphoglycerate:NAD+ oxidoreductase; α-phosphoglycerate dehydrogenase; 3-phosphoglycerate dehydrogenase; 3-phosphoglyceric acid dehydrogenase; D-3-phosphoglycerate dehydrogenase; glycerate 3-phosphate dehydrogenase; glycerate-1,3-phosphate dehydrogenase; phosphoglycerate oxidoreductase; phosphoglyceric acid dehydrogenase; SerA; 3-phosphoglycerate:NAD+ 2-oxidoreductase; SerA 3PG dehydrogenase; 3PHP reductase; αKG reductase; D- and L-HGA. Cat No: EXWM-0379. | |
| UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase | This enzyme participates in the biosynthetic pathway for UDP-α-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-α-D-mannuronic acid), an important precursor of B-band lipopolysaccharide. The enzymes from Pseudomonas aeruginosa serotype O5 and Thermus thermophilus form a complex with the the enzyme catalysing the next step the pathway (EC 2.6.1.98, UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase). The enzyme also possesses an EC 1.1.99.2 (L-2-hydroxyglutarate dehydrogenase) activity, and utilizes the 2-oxoglutarate produced by EC 2.6.1.98 to regenerate the tightly bound NAD+. The enzymes from Bordetella pertussis and Chromobacterium violaceum do not bind NAD+ as tightly and do not require 2-oxoglutarate to function. Group: Enzymes. Synonyms: WlbA; WbpB. Enzyme Commission Number: EC 1.1.1.335. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0249; UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase; EC 1.1.1.335; WlbA; WbpB. Cat No: EXWM-0249. | |
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