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| Product | Description | |
|---|---|---|
| L-701,324 | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. |  |
| L-701,324 | L-701,324 is a selective antagonist at the glycine site of the NMDA glutamate receptor. L-701,324 shows a beneficial action in the animal model of parkinsonian rigidity. L-701,324 is also a anticonvulsant which has a reduced propensity to activate mesolimbic dopaminergic systems in rodents. Preclinical trials for the treatment of Anxiety disorders, Epilepsy, Major depressive disorder and Psychotic disorders were discontinued. Uses: Anxiety disorders; epilepsy; major depressive disorder; psychotic disorders. Synonyms: L701324; L 701324; L-701324; L701324; L 701324; L-701324; 7-CHLORO-4-HYDROXY-3-(3-PHENOXY)PHENYL-2(1H)-QUINOLINONE;7-CHLORO-4-HYDROXY-3-(3-PHENOXY )PHENYLQUINOLIN-2[1H]-ONE. Grades: 98 %. CAS No. 142326-59-8. Molecular formula: C21H14ClNO3. Mole weight: 363.79. |  |
| L-701,324 (7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone) | A highly potent and selective antagonist for thenMDA receptor glycine site (IC50 = 2.0nM; Kd = 28nM; ED50 = 0.9nM either intraperitoneal (ip) or oral (po) adminited). The first such compounds with significant activity in the central nervous system following oral dosing and a potent, active anticonvulsant with a reduced propensity to activate mesolimbic dopaminergic systems in rodents. Group: Biochemicals. Grades: Highly Purified. CAS No. 142326-59-8. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
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