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| Product | Description | |
|---|---|---|
| L-745,870 trihydrochloride | L-745,870 trihydrochloride is the trihydrochloride salt of L-745,870, which is highly selective and potent D4 dopamine receptor antagonist with Ki value of 0.51nM. It is > 1000-fold selective over 5-HT2, D1 and D5 receptors. It has antipsychotic effects in animal models, but it was not effective in human trials. Synonyms: L-745,870 trihydrochloride; L 745,870 trihydrochloride; L745,870 trihydrochloride; 3-(4-[4-Chlorophenyl]piperazin-1-yl)-methyl-1H-pyrrolo[2,3-b]pyridine trihydrochloride. Grades: ≥99% by HPLC. CAS No. 866021-03-6. Molecular formula: C18H22N4Cl2. Mole weight: 436.21. |  |
| L-745,870 Trihydrochloride (Dopamine D4 Receptor Antagonist, L-745,870 Trihydrochloride, L-745870, L745870) | Selective D4 receptor antagonist with excellent brain penetration. Displays an affinity (Ki) of 0.4nM for human D4 receptors with >1000-fold binding selectivity over D2 and D3 receptors. Does not block agonist-induced activation of GIRK currents. It is used frequently in retinal and CNS studies of D4 modulation. Group: Biochemicals. Grades: Highly Purified. CAS No. 158985-00-3. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
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