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| Product | Description | |
|---|---|---|
| L002 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| L002 | L002. Group: Biochemicals. Grades: Purified. CAS No. 321695-57-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| L002 | L002 is an inhibitor of p300 histone acetyltransferase with IC50 value of 1.98 μM in vitro, which is a lysine acetyltransferase that catalyzes acetyl group attachment to lysine residues of a variety of proteins. It has weaker inhibitory effects against PCAF and GCN5. It acts as a critical coactivator of several oncogenic transcription factors involved in cancer cell survival and proliferation. It blocks acetylation of histones and p53, and reduces STAT3 phosphorylation in MDA-MB-468 xenografts, leukemia and lymphoma cell lines. It induces growth arrest and apoptosis in certain cancer cell lines and suppresses the growth of triple-negative breast cancer xenografts. Synonyms: 2,6-Dimethyl-2,5-cyclohexadiene-1,4-dione 4-[O-[(4-methoxyphenyl)sulfonyl]oxime]; 4-[O-[(4-Methoxyphenyl)sulfonyl]oxime]-2,6-dimethyl-2,5-cyclohexadiene-1,4-dione; NSC764414; NSC 764414; NSC-764414; L002; L 002; L-002. Grades: ≥98% by HPLC. CAS No. 321695-57-2. Molecular formula: C15H15NO5S. Mole weight: 321.35. |  |
| OG-L002 | OG-L002 potently inhibits HSV IE gene expression in both HeLa and HFF cells with IC50s of ~10 μM and ~3 μM, respectively. OG-L002 is a potent and highly selective inhibitor of LSD1 (IC50 = 0.02 μM), and is a potent inhibitor of monoamine oxidases (MAO) with IC50s of 1.38 and 0.72 μM for MAO-A and MAO-B, respectively. Synonyms: 4'-[(1R,2S)-2-Aminocyclopropyl]-[1,1'-biphenyl]-3-ol; 4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-ol; [1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-; 4'-[(1R,2S)-2-Aminocyclopropyl]-3-biphenylol. Grades: >98%. CAS No. 1357302-64-7. Molecular formula: C15H15NO. Mole weight: 225.29. | |
| OG-L002 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| OG-L002 hydrochloride | OG-L002 hydrochloride is a selective inhibitor of lysine specific demethylase 1 (LSD1/KDM1A/H3K9 demethylase). OG-L002 effectively inhibits herpes simplex virus (HSV) IE gene expression, genome replication, and reactivation from latency. Synonyms: OG-L002 HCl; OG L002 HCl; OGL002 HCl; OG-L002 Hydrochloride; OG L002 Hydrochloride; OGL002 Hydrochloride; 4-[(1R,2S)-2-Aminocyclopropyl]-[1,1-biphenyl]-3-ol Hydrochloride. Grades: 99%. CAS No. 1357298-75-9. Molecular formula: C15H15NO.HCl. Mole weight: 261.75. | |
| p300/CBP Inhibitor VI, L002 (4- (4-Methoxyphenyl sulfonyl oxyimino) -2, 6-di methyl -2, 5-cyclohexadien-1-one, GCN5 Inhibitor III, Histone Acetyltransferase Inhibitor IX, PCAF Inhibitor IV) | A cell-permeable phenyl sulfonyl oxyimi nocyclohexadienone compound that acts as a potent, selective, and reversible inhibitor of p300 histone acetyl transferase (IC50 = 1.98uM). Shown to occupy Ac-CoA binding pocket of p300, and less potent to CBP, PCAF, GCN5 and GNAT. Suppresses Histone H3 and H4 acetylation in triple negative breast cancer cell line MDAMB-468 as well as in HCT116 cell line and blocks p300-mediated STAT3 phosphorylation in pancreatic cancer cell line MIA Paca-2. Does neither inhibit the activities of histone deacetylases 1, 6, and 11 nor 8-diverse histone methyltransferases tested (DOT1, EZH1, G9a, PRMT1, SETD2, SET7-9, SMYD2, and SUV39H2). Reported to suppress tumor growth in mice bearing tumor xenografts of MDAMB-468 cell line (at 500ug/100ul, i.p. twice a week). Group: Biochemicals. Grades: Highly Purified. CAS No. 321695-57-2. Pack Sizes: 10mg. Molecular Formula: C??H??NO?S. US Biological Life Sciences. | Worldwide |
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