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| Product | Description | |
|---|---|---|
| Larotrectinib | Larotrectinib (LOXO-101) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C). Uses: Scientific research. Group: Signaling pathways. Alternative Names: LOXO-101; ARRY-470. CAS No. 1223403-58-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12866. |  |
| Larotrectinib sulfate | Larotrectinib sulfate (LOXO-101 sulfate; ARRY-470 sulfate) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C). Uses: Scientific research. Group: Signaling pathways. Alternative Names: LOXO-101 sulfate; ARRY-470 sulfate. CAS No. 1223405-08-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12866A. | |
| Larotrectinib Sulfate (ARRY 470, LOXO 101) | A potent ATP-competitive inhibitor of tropomyosin-related kinases (TRK1, TRK2 and TRK3), members of the receptor tyrosine kinase family of neurotrophin receptors. Tumors with oncogenic TRK fusions are sensitive to larotrectinib, leading to reduced proliferation and tumor growth in patients with soft tissue sarcoma, triple-negative breast cancer and lung cancer.A potent ATP-competitive inhibitor of tropomyosin-related kinases (TRK1, TRK2 and TRK3), members of the receptor tyrosine kinase family of neurotrophin receptors. Tumors with oncogenic TRK fusions are sensitive to larotrectinib, leading to reduced proliferation and tumor growth in patients with soft tissue sarcoma,...odels. The TRK family of neurotrophin receptors, TRKA, TRKB, and TRKC (encoded by NTRK1, NTRK2, and NTRK3 genes, respectively) and their neurotrophin ligands regulate growth, differentiation and survival of neurons. Group: Biochemicals. Alternative Names: (3S) -N- [5- [ (2R) -2- (2, 5-Difluorophenyl) -1-pyrrolidinyl] pyrazolo [1, 5-a] pyrimidin-3-yl] -3-hydroxy-1-pyrrolidinecarboxamide ; ARRY 470; LOXO 101; Vitrakvi.; (S) -N- (5- ( (R) -2- (2, 5-difluorophenyl) pyrrolidin-1-yl) pyrazolo[1, 5-a]pyrimidin-3-yl) -3-hydroxypyrrolidine-1-carboxamide Sulfate. CAS No. 1223405-08-0. Pack Sizes: 10mg, 25mg, 50mg. Molecular Formula: C??H??F?N?O? H?O?S. US Biological Life Sciences. |  Worldwide |
| LOXO-101 (ARRY-470) | LOXO-101, also known as ARRY-470, is an orally bioavailable, potent, ATP-competitive inhibitor of TRKA, TRKB, and TRKC. LOXO-101 has IC50 values in the low nanomolar range for inhibition of all three TRK family members in binding and cellular assays, with 100x selectivity over other kinases, and has shown acceptable pharmaceutical properties and safety in nonclinical models. Synonyms: Larotrectinib; ARRY 470; LOXO 101; (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide. Grades: 98%. CAS No. 1223403-58-4. Molecular formula: C21H22F2N6O2. Mole weight: 428.44. |  |
| LOXO-101 sulfate | The sulfate salt form of LOXO-101, also called Larotrectinib, which is an ATP-competitive inhibitor of tropomyosin receptor kinases. It was approved by FDA for the treatment of metastatic solid tumors. Synonyms: LOXO-101 sulfate; LOXO 101 sulfate; LOXO101 sulfate; Larotrectinib sulfate; (3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxypyrrolidine-1-carboxamide sulfate. Grades: >95%. CAS No. 1223405-08-0. Molecular formula: C21H24F2N6O6S. Mole weight: 526.51. | |
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