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| Product | Description | |
|---|---|---|
| LCZ696 (valsartan + sacubitril) impurity 19 | LCZ696 (valsartan + sacubitril) impurity 19. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2S,4R)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid. CAS No. 1012341-54-6. Molecular formula: C23H29NO4. Mole weight: 383.48. Catalog: APB1012341546. |  |
| LCZ696 (valsartan + sacubitril) impurity 20 | LCZ696 (valsartan + sacubitril) impurity 20. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2R,4R)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid. CAS No. 1012341-56-8. Molecular formula: C23H29NO4. Mole weight: 383.48. Catalog: APB1012341568. | |
| LCZ696 (valsartan + sacubitril) impurity 21 | LCZ696 (valsartan + sacubitril) impurity 21. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2S,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid. CAS No. 1012341-52-4. Molecular formula: C23H29NO4. Mole weight: 383.48. Catalog: APB1012341524. | |
| (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride | (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride is used as a reagent in the synthesis of LCZ696, an angiotensin II receptor and neprilysin receptor dual inhibitor. (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride is also used as a reagent in the preparation of novel NEP inhibitor prodrugs for the treatment of hypertension and cardiovascular diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 149690-12-0. Pack Sizes: 50mg, 250mg. Molecular Formula: C20H26ClNO2. US Biological Life Sciences. |  Worldwide |
| AHU-377 hemicalcium salt | LCZ696 is a novel single molecule comprising molecular moieties of valsartan and NEP inhibitor prodrug AHU377 (1:1 ratio). Oral administration of LCZ696 caused dose-dependent increases in atrial natriuretic peptide immunoreactivity (due to NEP inhibition) in Sprague-Dawley rats and provided sustained, dose-dependent blood pressure reductions in hypertensive double-transgenic rats. In healthy participants, a randomized, double-blind, placebo-controlled study (n = 80) of single-dose (200-1200 mg) and multiple-dose (50-900 mg once daily for 14 days) oral administration of LCZ696 showed that peak plasma concentrations were reached rapidly for valsartan (1.6-4.9 hours), AHU377 (0.5-1.1 hours), and its active moiety, LBQ657 (1.8-3.5 hours). LCZ696 is superior to valsartan alone in reducing blood pressure. Preliminary results from a Phase II trial showed that LCZ696 reduced NT-proBNP to a greater extent than valsartan alone, and in addition LCZ696 had beneficial effects on symptoms. Synonyms: calcium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate; AHU337; AHU-337; AHU 337; LCZ696; LCZ 696; LCZ696; Sacubitril. Grade: >98%. CAS No. 1369773-39-6. Molecular formula: C24H28NO5-. Mole weight: 410.48. |  |
| Sacubitril | Sacubitril (AHU-377) is a potent and orally active NEP (neprilysin) inhibitor with an IC 50 of 5 nM. Sacubitril is a component of the heart failure medicine LCZ696. Sacubitril can be used for the research of heart failure, hypertension and COVID-19 [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AHU-377. CAS No. 149709-62-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15407. |  |
| Sacubitril sodium | Sacubitril sodium is a potent and orally active NEP (neprilysin) inhibitor, with an IC 50 of 5 nM. Sacubitril sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril sodium is a component of the heart failure medicine LCZ696. Sacubitril sodium can be used for the research of heart failure, hypertension and COVID-19 [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AHU-377 sodium. CAS No. 149690-05-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15407B. | |
| Sacubitril/Valsartan | Sacubitril/Valsartan (LCZ696), comprised Valsartan and Sacubitril (AHU377) in 1:1 molar ratio, is a first-in-class, orally bioavailable, and dual-acting angiotensin receptor-neprilysin (ARN) inhibitor for hypertension and heart failure [1] [2] [3]. Sacubitril/Valsartan ameliorates diabetic cardiomyopathy by inhibiting inflammation, oxidative stress and apoptosis [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LCZ696. CAS No. 936623-90-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-18204A. | |
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