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| Product | Description | |
|---|---|---|
| LDN-193189 | LDN193189 is a selective and potent ALK inhibitor with potential anticancer activity. Uses: Differentiation. Synonyms: 4-[6-(4-Piperazin-1-yl-phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline; LDN193189; LDN 193189; LDN-193189. Grades: 0.98. CAS No. 1062368-24-4. Molecular formula: C25H22N6. Mole weight: 406.48238. |  |
| LDN-193189 dihydrochloride | LDN-193189 (dihydrochloride) is a potent selective BMP type I receptor (BMP I) inhibitor. LDN-193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC 50 values of 5 nM and 30 nM, respectively. LDN-193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DM-3189 dihydrochloride. CAS No. 1435934-00-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-12071B. |  |
| LDN-193189 HCl | LDN193189 HCl is the hydrochloride salt of LDN193189, which is a selective BMP signaling inhibitor, and inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively. Synonyms: LDN-193189 monohydrochloride; LDN 193189 monohydrochloride; LDN193189 monohydrochloride. Grades: >98%. CAS No. 1062368-62-0. Molecular formula: C25H22N6.HCl. Mole weight: 442.94. | |
| K02288 | K02288 is a highly selective 2-aminopyridine based inhibitor with in vitro activity against ALK2 at low nanomolar concentrations similar to the current lead compound LDN-193189. K02288 specifically inhibits the BMP-induced Smad pathway without affecting TGF-b signaling and induced dorsalization of zebrafish embryos. Synonyms: K-02288; 3-(6-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenol. Grades: >98%. CAS No. 1431985-92-0. Molecular formula: C20H20N2O4. Mole weight: 352.38. | |
| LDN193189 | LDN193189 is a potent selective BMP type I receptor (BMP I) inhibitor. LDN-193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC 50 values of 5 nM and 30 nM, respectively. LDN-193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DM-3189. CAS No. 1062368-24-4. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-12071. | |
| LDN 193189 dihydrochloride | LDN 193189 dihydrochloride is a selective ALK2 and ALK3 inhibitor with IC50 values of 5 and 30 nM. It can inhibit FOP and ectopic ossification. LDN 193189 is a potential agent in the treatment of NSCLC lung tumors. Synonyms: LDN 193189 dihydrochloride; LDN193189 dihydrochloride; LDN-193189 dihydrochloride; 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1435934-00-1. Molecular formula: C25H22N6.2HCl. Mole weight: 479.4. | |
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