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| Product | Description | |
|---|---|---|
| LDN-214117 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| LDN-214117 | LDN-214117 is an orally active ALK2 inhibitor with well-tolerated and good brain penetration. LDN-214117 has a high selectivity and low cytotoxicity for ALK2 with an IC50 value of 24 nM. LDN-214117 also is a specific bone morphogenetic proteins (BMPs) signaling inhibitor and has relatively selective inhibition for BMP6 with an IC50 value of 100 nM. LDN-214117 can be used for the research of fibrodysplasia ossificans progressiva (FOP), diffuse intrinsic pontine glioma (DIPG) [1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1627503-67-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16712. |  |
| LDN-214117 | LDN-214117 is a potent and selective ALK2 inhibitor (IC50 = 24nM). It shows selectivity for ALK2 and ALK1 over ALK3, and exhibits 164-fold selectivity for BMP6 inhibition (IC50 = 100 nM) over TGF-β1. Synonyms: LDN 214117; 1-[4-[6-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]piperazine. Grades: >98%. CAS No. 1627503-67-6. Molecular formula: C25H29N3O3. Mole weight: 419.52. |  |
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