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| Product | Description | |
|---|---|---|
| LDN-57444 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| LDN-57444 | LDN-57444 is a reversible, competitive proteasome inhibitor for UCH-L1 with IC50 of 0.88 μM, 28-fold greater selectivity over isoform UCH-L3. Synonyms: ARO 002; ARO002; ARO-002; LDN-57444; LDN 57444; LDN57444. Grades: >98%. CAS No. 668467-91-2. Molecular formula: C17H11Cl3N2O3. Mole weight: 397.64. |  |
| LDN 57444, UCH-L1 Inhibitor (5-Chloro-1-[(2,5-dichlorophenyl)met. hyl]-1H-indole-2,3-dione 3-(O-acetyloxime)) | Cell-permeable. LDN-57444 is a potent, reversible, competitive and active site-directed inhibitor of UCHL1 (Ki = 0.4uM). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis. Causes dramatic alterations in synaptic protein distribution and spine morphology in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 668467-91-2. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. |  Worldwide |
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