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| Product | Description | |
|---|---|---|
| Leptomycin B | Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CI 940; LMB. CAS No. 87081-35-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-16909. |  |
| Leptomycin B (Elactocin, Antibiotic ATS 1287B, Antibiotic CI 940, Antibiotic CL 1957A, Antibiotic PD 114720, Mantuamycin) | Leptomycin B is the dominant and most studied member of the leptomycin class isolated from selected Streptomyces strains. Leptomycin B is a nanomolar active and specific nuclear export inhibitor. Its target is CRM1/exportin1 a protein in the nuclear export sequence (NES). Examples of proteins affected are c-Abl, cyclin B1, HIV-1 Rev, IκB, MPF, MAP/ERK, MDM2/p53, NF-κB/IκB7 and PKA. Export of many RNAs are also inhibited e.g. COX-2 and c-FOS mRNA. In addition Leptomycin B shows antifungal and antibacterial and potent antitumour activities. Group: Biochemicals. Alternative Names: Elactocin, Antibiotic ATS 1287B, Antibiotic CI 940, Antibiotic CL 1957A, Antibiotic PD 114720, Mantuamycin. Grades: Highly Purified. CAS No. 87081-35-4. Pack Sizes: 500ug. US Biological Life Sciences. |  Worldwide |
| Leptomycin B, Free Acid (Elactocin, Antibiotic ATS 1287B, Antibiotic CI 940, Antibiotic CL 1957A, Antibiotic PD 114720, Mantuamycin) | Leptomycin B (LepB) is a potent, specific inhibitor of nuclear export signal (NES)-dependent protein export from the nucleus. Group: Biochemicals. Grades: Highly Purified. CAS No. 87081-35-4. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Anguinomycin A (5-Demethyl-leptomycin A, KR 2827A, Antibiotic KR 2827A) | Anguinomycin A, isolated from a Streptomyces sp., displays nanomolar cytotoxicity to murine P388 leukemia cells. In addition, it shows antitumour activity in mice against murine Lewis lung carcinoma and P388 leukemia. Anguinomycin A is an analogue of Leptomycin B, an inhibitor of nuclear export of proteins. Group: Biochemicals. Alternative Names: 5-Demethyl-leptomycin A, KR 2827A, Antibiotic KR 2827A. Grades: Highly Purified. CAS No. 111278-01-4. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Kazusamycin A (Kazusamycin, Hydroxyleptomycin B, Hydroxyelactocin, Antibiotic CL 1957B, Antibiotic PD 114721) | Kazusamycin A is a minor member of the leptomycin complex isolated from some Streptomyces species. It is an hydroxylated analogue of Leptomycin B, a nuclear export inhibitor. Kazusamycin A exhibits potent antitumour activity both in vitro and in vivo against P388 and L1210 cell lines and also shows strong antibacterial and antifungal activity. Group: Biochemicals. Alternative Names: Kazusamycin, Hydroxyleptomycin B, Hydroxyelactocin, Antibiotic CL 1957B, Antibiotic PD 114721. Grades: Highly Purified. CAS No. 92090-94-3. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Kazusamycin B (Hydroxyleptomycin A, Antibiotic CL 1957E, Antibiotic PD 124895, 3. PD 124,895 ) | Kazusamycin B is a minor component of the leptomycin complex produced by some Streptomyces sp. It is an hydroxylated analogue of Leptomycin A, a nuclear export inhibitor. Kazusamycin B displays potent antitumour activity against L1210 and human colon adenocarcinoma and in vivo activity against P388 lymphocytic leukemia in mice. Kazusamycin B also possesses strong antibacterial and antifungal activity. Group: Biochemicals. Alternative Names: Hydroxyleptomycin A, Antibiotic CL 1957E, Antibiotic PD 124895, 3. PD 124,895. Grades: Highly Purified. CAS No. 107140-30-7. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Leptomycin A (Antibiotic ATS 1287A, Antibiotic PD 118607, Jildamycin) | Leptomycin A, a methyl (cf. ethyl) analogue of Leptomycin B, is a minor component of the leptomycin complex produced by selected Streptomyces species. Leptomycin B is a potent inhibitor of the nuclear transport receptor CRM1. Leptomycin A is also likely to inhibit nuclear transport and may offer differences in exporter selectivity. Leptomycin A shows antimicrobial activity against Schizosaccaromyces pombe and Mucor rouxianus. Group: Biochemicals. Alternative Names: Antibiotic ATS 1287A, Antibiotic PD 118607, Jildamycin. Grades: Highly Purified. CAS No. 87081-36-5. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Kazusamycin A | A minor member of the leptomycin complex isolated from some streptomyces species; an hydroxylated analogue of leptomycin B, a nuclear export inhibitor; exhibits potent antitumour activity both in vitro and in vivo against P388 and L1210 cell lines, and also shows strong antibacterial and antifungal activity. Synonyms: 3-HYDROXYLEPTOMYCIN B; 2,10,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-9-(hydroxymethyl)-3,5,7,11,15-pentamethyl-8-oxo-; CL 1957B, PD 114721. Grades: >95% by HPLC. CAS No. 92090-94-3. Molecular formula: C33H48O7. Mole weight: 556.73. |  |
| Kazusamycin B | A minor component of the leptomycin complex produced by some streptomyces sp.; an hydroxylated analogue of leptomycin A, a nuclear export inhibitor; displays potent antitumour activity against L1210 and human colon adenocarcinoma, and in vivo activity against P388 lymphocytic leukemia in mice; also possesses strong antibacterial and antifungal activity. Synonyms: PD 124895; 2,10,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-9-(hydroxymethyl)-3,5,7,11,15,17-hexamethyl-8-oxo-. Grades: >95% by HPLC. CAS No. 107140-30-7. Molecular formula: C32H46O7. Mole weight: 542.70. | |
| Leptomycin A | a potent anti-fungal antibiotic. Leptomycin A is a highly specific inhibitor of export protein CRM1. Synonyms: Jildamycin; Antibiotic ATS 1287A; Antibiotic PD 118607; 2,10,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo-. Grades: >99% by HPLC. CAS No. 87081-36-5. Molecular formula: C32H46O6. Mole weight: 526.71. | |
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