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| Product | Description | |
|---|---|---|
| Leukadherin-1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Leukadherin-1 (aMb2 Agonist II, CD11b Agonist II, LA1, Mac-1 Agonist II, CR3 Agonist II, CD11b/CD18 Agonist, 4-(5-((3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)-benzoic Acid) | A furanyl thiazolidinone compound that binds CD11b aA/aI domain in a reversible manner and stabilizes aA in a high-affinity binding conformation toward known CD11b/CD18 (aMB2; CR3; Mac-1) ligands, fibrinogen, ICAM-1, and iC3B. Reported to be superior to IMB-10 in enhancing Mac-1-mediated cell adhesion (EC50=4 vs. >50uM on fibrinogen surface). Effectively suppresses leukocyte recruitment in various inflammatory disease models involving mice, rats, and zebrafish embryos in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. |  Worldwide |
| (Z)-Leukadherin-1 | (Z)-Leukadherin-1, an orally active and allosteric CD11b agonist, leads to repolarization of tumor-associated macrophages, reduces the number of tumor-infiltrating immunosuppressive myeloid cells, and enhances dendritic cell response. Synonyms: ADH-503 free base; (Z)-4-(5-((3-benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid; Benzoic acid, 4-[5-[(Z)-[4-oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-; 4-{5-[(Z)-(3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]-2-furyl}benzoic acid. Grade: ≥98%. CAS No. 2055362-72-4. Molecular formula: C22H15NO4S2. Mole weight: 421.49. |  |
| ADH-503 | ADH-503 is an allosteric agonist of integrin CD11b/CD18. Synonyms: (Z)-Leukadherin-1 choline; Leukadherin-1 choline salt; GB1275. CAS No. 2055362-74-6. Molecular formula: C22H15NO4S2.xC5H14NO. Mole weight: 525.66. | |
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