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| Product | Description | |
|---|---|---|
| Leukotriene C4 | Leukotriene C4 is a cysteinyl leukotriene produced by the LTC4 synthase catalyzed conjugation of glutathione to LTA4. LTC4 acts as an agonist of smooth muscle contraction. LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute allergic hypersensitivity. Synonyms: LTC4; 5S,6R-Ltc(sub 4); 6R-(((R)-2-((S)-4-amino-4-carboxybutanamido)-3-((carboxymethyl)amino)-3-oxopropyl)thio)-5S-hydroxyicosa-7E,9E,11Z,14Z-eicosatetraenoic acid. Grades: ≥97%. CAS No. 72025-60-6. Molecular formula: C30H47N3O9S. Mole weight: 625.78. |  |
| Leukotriene C4 | Leukotriene C4 is a eicosanoid lipid mediator and produced by immune cells during type 2 inflammation. Leukotriene C4 can mediate inflammation,allergy, bronchoconstriction, and vascular leakage [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 72025-60-6. Pack Sizes: 25 μg (159.8 μM * 250 μL in Ethanol). Product ID: HY-113446. |  |
| LEUKOTRIENE C4 | LEUKOTRIENE C4. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Leukotriene C4 Lipid. Appearance: Colorless liquid. CAS No. 72025-60-6. Molecular formula: C30H47N3O9S. Mole weight: 625.77. Purity: 0.97. Product ID: ACM72025606. Alfa Chemistry ISO 9001:2015 Certified. Categories: Leukotriene C4 synthase. |  |
| Leukotriene C4 methyl ester | Leukotriene C4 is a cysteinyl leukotriene produced by the LTC4 synthase catalyzed conjugation of glutathione to LTA4. LTC4 acts as an agonist of smooth muscle contraction. LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute allergic hypersensitivity. Synonyms: LTC4 methyl ester; Leukotriene C4 monomethyl ester. Grades: ≥97%. CAS No. 73958-10-8. Molecular formula: C31H49N3O9S. Mole weight: 639.8. | |
| 11-trans Leukotriene C4 | 11-trans Leukotriene C4 is a C-11 double bond isomer of LTC4. Group: Biochemicals. Grades: Highly Purified. CAS No. 74841-69-3. Pack Sizes: 25ug, 50ug. Molecular Formula: C30H47N3O9S, Molecular Weight: 625.77. US Biological Life Sciences. |  Worldwide |
| 11-Trans leukotriene C4 | 11-Trans leukotriene C4 is a C-11 double bond isomer of LTC4. Synonyms: 11-trans LTC4; Leucotriene C4. Grades: ≥97%. CAS No. 74841-69-3. Molecular formula: C30H47N3O9S. Mole weight: 625.8. | |
| 14,15-Leukotriene C4 | 14,15-Leukotriene C4 is an acute inflammatory mediator. Group: Biochemicals. Grades: Highly Purified. CAS No. 75290-60-7. Pack Sizes: 25ug, 50ug. Molecular Formula: C30H47N3O9S, Molecular Weight: 625.77. US Biological Life Sciences. | Worldwide |
| leukotriene-C4 hydrolase | The mouse enzyme is specific for leukotriene C4, while the human enzyme also has considerable activity towards glutathione and oxidized glutathione (cf. EC 3.4.19.13, glutathione hydrolase). Group: Enzymes. Synonyms: γ-glutamyl leukotrienase; GGT5. Enzyme Commission Number: EC 3.4.19.14. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4086; leukotriene-C4 hydrolase; EC 3.4.19.14; γ-glutamyl leukotrienase; GGT5. Cat No: EXWM-4086. |  |
| leukotriene-C4 synthase | The reaction proceeds in the direction of addition. Not identical with EC 2.5.1.18, glutathione transferase. Group: Enzymes. Synonyms: leukotriene C4 synthetase; LTC4 synthase; LTC4 synthetase; leukotriene A4:glutathione S-leukotrienyltransferase; (7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathioneleukotriene-transferase (epoxide-ring-opening); (7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming). Enzyme Commission Number: EC 4.4.1.20. CAS No. 90698-32-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5322; leukotriene-C4 synthase; EC 4.4.1.20; 90698-32-1; leukotriene C4 synthetase; LTC4 synthase; LTC4 synthetase; leukotriene A4:glutathione S-leukotrienyltransferase; (7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathioneleukotriene-transferase (epoxide-ring-opening); (7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming). Cat No: EXWM-5322. | |
| N-methyl Leukotriene C4 | N-methyl Leukotriene C4 (N-methyl LTC4) is a synthetic analog of Leukotriene C4 (LTC4) that is not readily metabolized to LTD4 and LTE4. It acts as a potent and selective CysLT2 receptor agonist. Synonyms: N-methyl LTC4. Grades: ≥97%. CAS No. 131391-65-6. Molecular formula: C31H49N3O9S. Mole weight: 639.8. | |
| 1- [ [ [ (1R) -1- [3- [ (2S, R) -2- [ [ (1-Carboxycyclopropyl ) methyl ] thio] -2- (7-chloro-2-quinolinyl) ethyl] phenyl] -3- [2- (1-hydroxy-1- methyl ethyl) phenyl] propyl ] thio] methyl cyclopropaneacetic Acid | 1- [ [ [ (1R) -1- [3- [ (2S, R) -2- [ [ (1-Carboxycyclopropyl ) methyl ] thio] -2- (7-chloro-2-quinolinyl) ethyl] phenyl] -3- [2- (1-hydroxy-1- methyl ethyl) phenyl] propyl ] thio] methyl cyclopropaneacetic Acid is derived from Montelukast Methyl Ester (M568080), which is an impurity of the antiasthmatic drug Montelukast (M568000), a selective leukotriene D4-receptor antagonist. Used as an anti-asthmatic. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C41H46ClNO5S2, Molecular Weight: 732.39. US Biological Life Sciences. | Worldwide |
| 1- [ [ [ (1R) -1- [3- [ (2S, R) -2- [ [ (1-Carboxycyclopropyl) methyl] thio] -2- (7-chloro-2-quinolinyl) ethyl] phenyl] -3- [2- (1-hydroxy-1-methylethyl) phenyl] propyl] thio] methylcyclopropaneacetic Acid | 1- [ [ [ (1R) -1- [3- [ (2S, R) -2- [ [ (1-Carboxycyclopropyl) methyl] thio] -2- (7-chloro-2-quinolinyl) ethyl] phenyl] -3- [2- (1-hydroxy-1-methylethyl) phenyl] propyl] thio] methylcyclopropaneacetic Acid is an impurity of Montelukast, which is a leukotriene D4-receptor antagonist used in the treatment of allergies and asthma. Molecular formula: C41H46ClNO5S2. Mole weight: 732.39. | |
| 2- [2-Methoxy-4- [ [ [ (2-methylphenyl) sulfonyl] amino] carbonyl] phenyl] methyl] Zafirlukast | 2- [2-Methoxy-4- [ [ [ (2-methylphenyl) sulfonyl] amino] carbonyl] phenyl] methyl] Zafirlukast is an impurity of Zafirlukast (Z125000); a potent, selective and orally active cysteinyl leukotriene type 1 receptor antagonist. Also used as an antiasthmatic. Group: Biochemicals. Grades: Highly Purified. CAS No. 1160235-26-6. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C47H48N4O10S2, Molecular Weight: 893.03. US Biological Life Sciences. | Worldwide |
| 2- [2-Methoxy-4- [ [ [ (2-methylphenyl) sulfonyl] amino] carbonyl] phenyl] methyl] Zafirlukast-d3 | 2- [2-Methoxy-4- [ [ [ (2-methylphenyl) sulfonyl] amino] carbonyl] phenyl] methyl] Zafirlukast-d3 is the isotope labelled analog of 2- [2-Methoxy-4- [ [ [ (2-methylphenyl) sulfonyl] amino] carbonyl] phenyl] methyl] Zafirlukast (M265710); an impurity of Zafirlukast (Z125000) which is a potent, selective and orally active cysteinyl leukotriene type 1 receptor antagonist. Also used as an antiasthmatic. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C47H45D3N4O10S2, Molecular Weight: 896.05. US Biological Life Sciences. | Worldwide |
| 2-Chloro Zafirlukast-d7 | 2-Chloro Zafirlukast-d7 is the isotope labelled analog of 2-Chloro Zafirlukast (C424225); an impurity of Zafirlukast (Z125000) which is a potent, selective and orally active cysteinyl leukotriene type 1 receptor antagonist. Also used as an antiasthmatic. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C31H25D7ClN3O6S, Molecular Weight: 617.16. US Biological Life Sciences. | Worldwide |
| 2-((E)-3-((1S)-1-((tert-Butyldimethylsilyl)oxy)-3-(2-(2-((tert-butyldimethylsilyl)oxy)oxiran-2-yl)phenyl)propyl)styryl)-7-chloroquinoline 1-Oxide | 2-((E)-3-((1S)-1-((tert-Butyldimethylsilyl)oxy)-3-(2-(2-((tert-butyldimethylsilyl)oxy)oxiran-2-yl)phenyl)propyl)styryl)-7-chloroquinoline 1-Oxide is an impurity of Montelukast, which is a leukotriene D4-receptor antagonist used in the treatment of allergies and asthma. Grades: 98%. Molecular formula: C40H52ClNO4Si2. Mole weight: 702.47. | |
| AM679 | AM679 is a drug which acts as a selective inhibitor of 5-Lipoxygenase-activating protein (FLAP). This protein is involved in the production of cysteinyl leukotrienes which are involved in inflammation, and AM679 has anti-inflammatory effects in animal studies. AM679 also showed potent inhibition of leukotrienes in human blood and in a rodent bronchoalvelolar lavage (BAL) challenge model. Research showed AM679 reduces inflammation in the respiratory syncytial virus-infected mouse eye. Synonyms: AM-679; AM 679; AM679; UNII-65KJ8P7M9D; CHEMBL595092; SCHEMBL503239; 65KJ8P7M9D. Grades: >98%. CAS No. 1206880-66-1. Molecular formula: C40H44N4O5S. Mole weight: 692.87. | |
| BW-B 70C | BW B70C is a potent and selective inhibitor of 5-lipoxygenase (5-LO). 5-LO is an enzyme that transforms essential fatty acids (EFAs) into leukotrienes and is activated by 5-lipoxygenase activating protein (FLAP). BW-B 70C had high potency and long duration in vivo and was considered as potential anti-asthma drug. It was reported that BW B70C blocks leukotriene C4 synthesis by alveolar macrophages, which decreases the migration for leukocyte to the airway lumen. BW B70C didn't affect vascular leucocyte margination and the blood levels of secreted phospholipase A2 and TNF-&alpha. Synonyms: N-[3-[3-(-Fluorophenoxy)phenyl]-1-methyl-2-propenyl]-N-hydroxyurea. Grades: ≥98%. CAS No. 134470-38-5. Molecular formula: C17H17FN2O3. Mole weight: 316.33. | |
| FPL 55712 | FPL 55712 is a leukotriene receptor antagonist that inhibits contraction of guinea pig trachealis induced by leukotrienes C4, D4, E4 and F4. Synonyms: FPL 55712; FPL55712; FPL-55712; 7-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]-4-oxo-8-propyl-4H-1-benzopyran-2-carboxylic acid. Grades: ≥97% by HPLC. CAS No. 40785-97-5. Molecular formula: C27H30O9. Mole weight: 498.52. | |
| FTY720 Hydrochloride (Gilenya, 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol. HCl, Fingolimod) | Cell permeable immunosuppressor displaying lymphocyte sequestration properties and used for treatment in multiple sclerosis. Potent sphingosine 1-phosphate (S1P) receptor (S1P1, S1P3, S1P4, and S1P5) agonist when phosphorylated by sphingosine kinase. Sphingosine transporter Abcb1 and leukotriene C4 transporter Abcc1 activity enhancer. Cytosolic phospholipase A2 inhibitor, independent of sphingosine 1-phosphate receptors. Autophagy inducer. Apoptosis inducer. Group: Biochemicals. Grades: Highly Purified. CAS No. 162359-56-0. Pack Sizes: 1mg, 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| glutathione hydrolase | This protein also has EC 2.3.2.2 (γ-glutamyltransferase) activity. The enzyme consists of two chains that are created by the proteolytic cleavage of a single precursor polypeptide. The N-terminal L-threonine of the C-terminal subunit functions as the active site for both the cleavage and the hydrolysis reactions. The human enzyme also hydrolyses oxidized glutathione and leukotriene C4 with similar efficiency, while the mouse enzyme does not. Group: Enzymes. Synonyms: glutathionase; GGT (ambiguous); γ-glutamyltranspeptidase (ambiguous). Enzyme Commission Number: EC 3.4.19.13. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4085; glutathione hydrolase; EC 3.4.19.13; glutathionase; GGT (ambiguous); γ-glutamyltranspeptidase (ambiguous). Cat No: EXWM-4085. | |
| Leukotriene c3 | Leukotriene c3. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Leukotriene C-3, Leukotriene C3, PDSP1_000718, PDSP2_000708, CID6438868, 5-Hydroxy-6-S-glutathionyl-7,9,11-eicosatrienoic acid, 77209-77-9, Glycine, N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6-pentadecatrienyl)-N-L-gamma-glutamyl-L-cysteinyl)-, (R-(R*,S*-(E,E,Z)))-. Product Category: Heterocyclic Organic Compound. CAS No. 77209-77-9. Molecular formula: C31H51N3O8S. Mole weight: 625.82. Purity: 0.96. IUPACName: (5S,7E,9E,11E)-6-[(2R)-2-[[(4S)-4-amino-5-hydroxy-5-oxopentanoyl]amino]-3-(carboxymethylamino)-3-oxopropyl]sulfanyl-5-hydroxyicosa-7,9,11-trienoic acid. Product ID: ACM77209779. Alfa Chemistry ISO 9001:2015 Certified. Categories: Leukotriene C4 synthase. | |
| Montelukast Acyl-β-D-glucuronide Acetic Acid Salt | Montelukast Acyl-β-D-glucuronide Acetic Acid Salt is a metabolite of Montelukast, which is a leukotriene D4-receptor antagonist used in the treatment of allergies and asthma. Synonyms: 1-O- ({1-[ ({ (1R) -1-{3-[ (E) -2- (7-Chloro-2-quinolinyl) vinyl]phenyl}-3-[2- (2-hydroxy-2-propanyl) phenyl]propyl}sulfanyl) methyl]cyclopropyl}acetyl) -α -D-erythro-hexopyranuronic acid acetate (1:1); α-D-erythro-Hexopyranuronic acid, 1- [2- [1- [ [ [ (1R) -1- [3- [ (E) -2- (7-chloro-2-quinolinyl) ethenyl] phenyl] -3- [2- (1-hydroxy-1-methylethyl) phenyl] propyl] thio] methyl] cyclopropyl] acetate] , acetate (1:1) (salt); 1- [1- [ [ [ (1R) -1- [3- [ (1E) -2- (7-Chloro-2-quinolinyl) ethenyl] phenyl] -3- [2- (1-hydroxy-1-methylethyl) phenyl] propyl] thio] methyl] cyclopropaneacetate] β-D-Glucopyranuronic Acid Acetic Acid Salt; Montelukast M1 Acetic acid Salt. Grades: ≥95%. Molecular formula: C43H48ClNO11S. Mole weight: 822.36. | |
| Montelukast-Acyl-Glucuronide | An impurity of Montelukast Sodium, which is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: 1-O-[2-[1-[[ (R) -1-[3-[ (E) -2- (7-Chloroquinolin-2-yl) ethenyl]phenyl]-3-[2- (1-methyl-1-hydroxyethyl) phenyl]propylthio]methyl]cyclopropan-1-yl]acetyl]-beta-D-glucopyranuronic acid. Grades: >95%. CAS No. 188717-17-1. Molecular formula: C41H44ClNO9S. Mole weight: 762.31. | |
| Montelukast Bis-sulfide (mixture of diastereomers) | Montelukast Bis-sulfide (mixture of diastereomers) is an impurity of Montelukast, which is a leukotriene D4-receptor antagonist used in the treatment of allergies and asthma. Synonyms: 1- [ [ [ (1R) -1- [3- [ (1R, S) -1- [ [ [1- (Carboxymethyl) cyclopropyl] methyl] thio] -2- (7-chloro-2-quinolinyl) ethyl] phenyl] -3- [2- (1-hydroxy-1-methylethyl) phenyl] propyl] thio] methyl] cyclopropaneacetic Acid; Montelukast Michael Aduct. CAS No. 1242260-05-4. Molecular formula: C41H46ClNO5S2. Mole weight: 732.39. | |
| Montelukast Dicyclohexylamine Salt | Montelukast is a leukotriene D4-receptor antagonist used in the treatment of allergies and asthma. Uses: A selective leukotriene d4-receptor antagonist. used as an antiasthmatic. Synonyms: 1- [1- [ [ [ (1R) -1- [3- [ (1E) -2- (7-Chloro-2-quinolinyl) ethenyl] phenyl] -3- [2- (1-hydroxy-1-methylethyl) phenyl] propyl] thio] methyl] cyclopropaneacetic N-Cyclohexylcyclohexanamine; Montelukast DCHA. Grades: 95%. CAS No. 577953-88-9. Molecular formula: C47H59ClN2O3S. Mole weight: 767.50. | |
| Montelukast R, R-Isomer | An impurity of Montelukast Sodium, which is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: 2- (1- ( ( ( (R) -1- (3- ( (R) -1- ( ( (1- (carboxymethyl) cyclopropyl) methyl) thio) -2- (7-chloroquinolin-2-yl) ethyl) phenyl) -3- (2- (2-hydroxypropan-2-yl) phenyl) propyl) thio) methyl) cyclopropyl) acetic acid. Grades: > 95%. Molecular formula: C41H46ClNO5S2. Mole weight: 732.41. | |
| R112 | R112 is a Syk inhibitor. R112 inhibited degranulation induced by anti-IgE cross-linking in mast cells (tryptase release, effective concentration for 50% inhibition [EC(50)] = 353 nmol/L) or basophils (histamine release, EC(50) = 280 nmol/L), and by allergen (dust mite) in basophils (histamine release, EC(50) = 490 nmol/L). R112 also blocked leukotriene C4 production and all proinflammatory cytokines tested. Subsequent molecular characterization indicated that R112 is an ATP-competitive spleen tyrosine kinase (Syk) inhibitor (inhibitory constant [K(I)] = 96 nmol/L). R112 was able to completely inhibit all three IgE-induced mast cell functions: degranulation, lipid mediator production, and cytokine production. R112 and its analogues offer a new modality in the treatment of allergic rhinitis. Synonyms: R112; R 112; R-112. CAS No. 575474-82-7. Molecular formula: C16H13FN4O2. Mole weight: 312.3. | |
| (S, E) -2- (3- (1- ( (tert-Butyldimethylsilyl) oxy) -3- (2- (1- ( (tert-butyldimethylsilyl) oxy) vinyl) phenyl) propyl) styryl) -7-chloroquinoline | (S, E) -2- (3- (1- ( (tert-Butyldimethylsilyl) oxy) -3- (2- (1- ( (tert-butyldimethylsilyl) oxy) vinyl) phenyl) propyl) styryl) -7-chloroquinoline is an impurity of Montelukast, which is a leukotriene D4-receptor antagonist used in the treatment of allergies and asthma. Molecular formula: C40H52ClN2Si2. Mole weight: 652.48. | |
| (S)-Verapamil hydrochloride | (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (S)-(-)-Verapamil hydrochloride. CAS No. 36622-28-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-135336A. | |
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