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| Product | Description | |
|---|---|---|
| Lexibulin | lexibulin, also known as CYT997, is an orally bioavailable small-molecule with tubulin-inhibiting, vascular-disrupting, and potential antineoplastic activities. Lexibulin inhibits tubulin polymerization in tumor blood vessel endothelial cells and tumor cells, blocking the formation of the mitotic spindle and leading to cell cycle arrest at the G2/M phase; this may result in disruption of the tumor vasculature and tumor blood flow, and tumor cell death. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). Synonyms: CYT997; CYT-997; CYT 997. lexibulin. CAS No. 917111-44-5. Molecular formula: C24H30N6O2. Mole weight: 434.544. |  |
| Lexibulin | Lexibulin (CYT-997) is a potent and orally active tubulin polymerisation inhibitor with IC50s of 10-100 nM in cancer cell lines; with potent cytotoxic and vascular disrupting activity in vitro and in vivo [1] [2]. Lexibulin induces cell apoptosis and induces mitochondrial ROS generation in GC cells [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CYT-997. CAS No. 917111-44-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-10498. |  |
| Lexibulin dihydrochloride | Lexibulin dihydrochloride is an orally bioavailable small-molecule with tubulin-inhibiting, vascular-disrupting, and potential antineoplastic activities. It inhibits tubulin polymerization in tumor blood vessel endothelial cells and tumor cells, blocking the formation of the mitotic spindle and leading to cell cycle arrest at the G2/M phase, which may result in disruption of the tumor vasculature and tumor blood flow, and tumor cell death. Synonyms: CYT-997 dihydrochloride; CYT 997 dihydrochloride; CYT997 dihydrochloride. Grades: >98%. CAS No. 917111-49-0. Molecular formula: C24H32Cl2N6O2. Mole weight: 507.46. | |
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