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| Product | Description | |
|---|---|---|
| LGK974 | LGK974 is a selective and orally bioavailable Porcupine inhibitor under development for the treatment of cancers that are driven by the Wnt pathway in a Wnt ligand-dependent manner. LGK974 was shown to induce tumor regression in a Wnt-driven murine tumor model. Synonyms: LGK-974; WNT-974; 2-(2',3-Dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide; 2-[5-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide. Grades: >98%. CAS No. 1243244-14-5. Molecular formula: C23H20N6O. Mole weight: 396.454. |  |
| LGK974 (LGK-974, WNT-974, LGK 974, NVP-LGK974) | LGK974 is a highly potent inhibitor of Porcupine (PORCN), a Wnt-specific acyltransferase. LGK974 is orally bioavailable and inhibits WNT signaling in vitro and in vivo. It is reported to exhibit anti-tumor properties without increasing cytotoxicity. Group: Biochemicals. Alternative Names: 2-[5-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide; LGK-974; WNT-974; LGK 974; NVP-LGK974; 2,3-Dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-[2,4-bipyridine]-5-acetamide; 2-(2,3-Dimethyl-[2,4-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide. Grades: Highly Purified. CAS No. 1243244-14-5. Pack Sizes: 1mg, 5mg, 25mg, 100mg. Molecular Formula: C??H??N?O, Molecular Weight: 396.44. US Biological Life Sciences. |  Worldwide |
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