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| Product | Description | |
|---|---|---|
| LH846 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| LH846 | LH846 is a selective inhibitor of CK1δ, which displays no inhibitory activity at CK2. It inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein, showing to lengthen the circadian period in U2OS cells, with minimal effect on amplitude. Synonyms: LH846; LH 846; LH-846. Grades: >98%. CAS No. 639052-78-1. Molecular formula: C16H13ClN2OS. Mole weight: 316.81. |  |
| Casein Kinase I Inhibitor V, LH846 - CAS 639052-78-2 | The Casein Kinase I Inhibitor V, LH846 controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| Casein Kinase I Inhibitor V, LH846 (N-(5-Chloro-6-methyl-1,3-benzothiazol-2-yl)-2-phenylacetamide)(N-(5-Chloro-6-methylbenzo[d]thiazol-2-yl)-2-phenylacetamide) | A cell-permeable benzothiazolo compound that acts a potent, selective, and reversible inhibitor of CKIg (IC50=290nM). Exhibits much reduced potency towards CKle and CKla isoforms (IC50=1.3 and 2.5uM, respectively). Does not affect the activity of CK2 or other kinases in a 59-protein kinase panel. Shown to block CKld-dependent period protein PER1 phosphorylation and diminish its proteasomal degradation in a dose-dependent manner. Also, shown to lengthen the circadian period in U2OS cells (10h at 8uM) without significantly affecting the amplitude of Per2-dLuc and Bmal1-dLuc rhythms. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
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