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| Product | Description | |
|---|---|---|
| Liarozole | Liarozole (R75251; R85246) is an imidazole derivative and orally active retinoic acid (RA) metabolism-blocking agent (RAMBA). Liarozole inhibits the cytochrome P450 (CYP26)-dependent 4-hydroxylation of retinoic acid ( IC 50 =7 μM), resulting in increased tissue levels of retinoic acid. Liarozole shows antitumoral properties [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R75251. CAS No. 115575-11-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106019. |  |
| Liarozole | This active molecular has a potential antineoplastic activity. As a retinoic acid metabolism blocking agent (RAMBA), liarozole inhibits P450-dependent ATRA-4-hydroxylase to an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation. Meanwhile, liarozole also inhibits aromatase that catalyzes estrogen biosynthesis in rating-limited step. In Aug 2005, clinical development was ongoing for Ichthyosis in Europe.In Jan 2006, Phase-II/III clinical trials in Ichthyosis was ongoing in Europe and in Canada. Uses: Treatment for ichthyosis. Synonyms: 6-[(3-chlorophenyl)-imidazol-1-ylmethyl]-1H-benzimidazole, R 75251; R-75251; R75251. Grades: 98%. CAS No. 115575-11-6. Molecular formula: C17H13ClN4. Mole weight: 308.771. |  |
| Liarozole dihydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Liarozole dihydrochloride | Liarozole dihydrochloride is a cytochrome P450 inhibitor. It displays antitumor activity against androgen-dependent and independent rat prostate carcinomas. Synonyms: 5-[(3-Chlorophenyl)-1H-imidazol-1-ylmethyl]-1H-benzimidazole dihydrochloride. Grades: ≥99% by HPLC. CAS No. 1883548-96-6. Molecular formula: C17H13ClN4.2HCl. Mole weight: 381.69. | |
| Liarozole dihydrochloride | Liarozole (R75251) dihydrochloride is an imidazole derivative and orally active retinoic acid (RA) metabolism-blocking agent (RAMBA). Liarozole dihydrochloride inhibits the cytochrome P450 (CYP26)-dependent 4-hydroxylation of RA ( IC 50 =7 μM), resulting in increased tissue levels of RA. Liarozole dihydrochloride shows antitumoral properties [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R75251 dihydrochloride. CAS No. 1883548-96-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-106019C. | |
| Liarozole hydrochloride | Liarozole hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 145858-50-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Liarozole hydrochloride | Liarozole is a benzimidazole derivative with potential antineoplastic activity. As a retinoic acid metabolism blocking agent (RAMBA), liarozole inhibits cytochrome P450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, resulting in an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation. This agent also inhibits aromatase, the enzyme that catalyzes the final, rate-limiting step in estrogen biosynthesis. Synonyms: Liarozole HCl; R75251 (hydrochloride); 5-((3-chlorophenyl)(1H-imidazol-1-yl)methyl)-1H-benzo[d]imidazole hydrochloride. CAS No. 145858-50-0. Molecular formula: C17H14Cl2N4. Mole weight: 345.23. | |
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