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| Product | Description | |
|---|---|---|
| Lifirafenib | Lifirafenib (BGB-283) is a novel and potent Raf Kinase and EGFR inhibitor with IC 50 values of 23 and 29 nM for recombinant BRaf V600E and EGFR, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BGB-283. CAS No. 1446090-79-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18957. |  |
| Lifirafenib | Lifirafenib is a Raf monomer and dimer inhibitor. It has been developed for the treatment of solid tumors. Synonyms: BGB-283; Beigene-283. CAS No. 1446090-79-4. Molecular formula: C25H17F3N4O3. Mole weight: 478.42. |  |
| BGB-283 | BGB-283 is a selective Epidermal growth factor receptor and Proto oncogene protein b raf inhibitor under the development of BeiGene. BGB-283 shows antitumor activity in B-RAF Mutated Colorectal Cancers. In vitro, BGB-283 can inhibit B-RAFV600E-activated ERK phosphorylation and cell proliferation. In vivo, BGB-283 can lead to dose-dependent tumor growth inhibition accompanied by partial and complete tumor regressions in both cell-line derived and primary human colorectal tumor xenografts bearing B-RAFV600E mutation. Phase I clinical trials for the treatment of solid tumours are on-going. Uses: Solid tumours. Synonyms: UNII-8762XZS5ZF; 8762XZS5ZF; BGB-283; BGB 283; BGB283; Beigene-283; Beigene283; Beigene 283; Lifirafenib; Compound 2.2b; Beigene-283; GTPL8958;5-[[(1R,1aS,6bR)-1-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one. Grades: 98%. CAS No. 1446090-77-2. Molecular formula: C25H17F3N4O3. Mole weight: 478.31. | |
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