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| Product | Description | |
|---|---|---|
| LIMKi 3 | LIMKi 3. Group: Biochemicals. Grades: Purified. CAS No. 1338247-35-0. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| LIM Kinase Inhibitor I, LIMKi 3 (N-(5-(1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyramide) | A cell-permeable pyrazolylthiazolo-isobutyramide compound that acts as a potent LIM kinase inhibitor (IC50 = 7 and 8nM against LIMK1 and LIMK2, respectively) and effectively suppresses cellular cofilin phosphorylation (IC50 ~1uM in A549 and MDA-MB-231 cultures) without affecting tubulin polymerization or inducing cytotoxicity (EC50 >10uM in A549 proliferation & colony formation assays). Shown to effectively destabilize F-actin structure in MDA-MB-231 breast cancer cells (3 to 10uM) with concomitant blockage of invasion (by 93% at 10uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 1338247-35-0. Pack Sizes: 10mg. Molecular Formula: C??H??Cl?F?N?OS. US Biological Life Sciences. | Worldwide |
| BMS-5 | BMS-5, a LIMK inhibitor, has been found to restrain the cofilin phosphorylation in MDA-MB-231 breast cancer cells. Synonyms: LIMKi 3; N-(5-(1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyramide; N-{5-[1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-1,3-thiazol-2-yl}-2-methylpropanamide; BMS 5; BMS5. Grades: 98%. CAS No. 1338247-35-0. Molecular formula: C17H14Cl2F2N4OS. Mole weight: 431.29. |  |
| T56-LIMKi | T56-LIMKi is a selective inhibitor of LIMK2 that reduces phosphorylated cofilin and inhibits the growth of Panc-1 cells with an IC50 of 35.2 μM. Synonyms: 3-methyl-N-[3-[[3- (trifluoromethyl) phenyl]carbamoyl]phenyl]-1, 2-oxazole-5-carboxamide; 3-methyl-N- (3- ( (3- (trifluoromethyl) phenyl) carbamoyl) phenyl) isoxazole-5-carboxamide ; T-5601640; T 5601640; T5601640; T56LIMKi; T56 LIMKi; T56-LIMKi. CAS No. 924473-59-6. Molecular formula: C19H14F3N3O3. Mole weight: 389.33. | |
| T56-LIMKi | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
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