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Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties [1]. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways [2]. Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC 50 value of 25.74 nM [3]. Uses: Scientific research. Group: Natural products. Alternative Names: LXA4. CAS No. 89663-86-5. Pack Sizes: 25 μg (283.71 μM * 250 μL in Ethanol). Product ID: HY-113509.
Intermediate in the preparation of labeled Lipoxin analogs. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Intermediate in the preparation of labeled Lipoxin analogs. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
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Bioactive Lipid Compound Library
A unique collection of 385 bioactive lipids related compounds for high throughput screening (HTS) and high content screening (HCS), including Agonists & Antagonists, Endocannabinoids, Farnesyl/geranylgeranyl derivates, HETEs deHETEs, hepoxilins, Polyunsaturated fatty acids, Leukotrienes, lipoxins, LPA & phosphatidic acids, Octadecanoids, PAFs, Prostaglandins & thromboxanes, Retinoids, vitamin D metabolites, Sphingolipids, etc. ; - Targets include GPCR, HDAC, PPAR, DNA Alkylating, EGFR, etc. ; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L7000. Categories: Bioactive Lipid Compounds Libraries.
BML 111
BML 111 is a FPR2 (lipoxin A4 receptor) agonist. It inhibits tumor-related angiogenesis and reduces tumor growth in hepatoma H22 cell bearing mice. BML 111 also protects against hemorrhagic shock-induced acute lung injury in rats and attenuates renal ischemia/reperfusion injury. Synonyms: BML-111; BML 111; BML111. (5S,6R)-Methyl 5,6,7-trihydroxyheptanoate; methyl (5S,6R)-5,6,7-trihydroxyheptanoate. CAS No. 78606-80-1. Molecular formula: C8H16O5. Mole weight: 192.21.
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