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| Product | Description | |
|---|---|---|
| Lometrexol | Lometrexol is a folate analog antimetabolite with antineoplastic activity. As the 6R diastereomer of 5,10-dideazatetrahydrofolate, lometrexol inhibits glycinamide ribonucleotide formyltransferase (GARFT), the enzyme that catalyzes the first step in the de novo purine biosynthetic pathway, thereby inhibiting DNA synthesis, arresting cells in the S phase of the cell cycle, and inhibiting tumor cell proliferation. The agent has been shown to be active against tumors that are resistant to the folate antagonist methotrexate. Uses: Antimetabolites, antineoplastic. Synonyms: Lometrexol; LMTX; LY 264618; LY-264618; LY264618. CAS No. 106400-81-1. Molecular formula: C21H25N5O6. Mole weight: 443.46. |  |
| Lometrexol disodium | Lometrexol is a folate analog antimetabolite with antineoplastic activity. Synonyms: LY 264618 disodium; LY264618 disodium; NSC-722969; NSC 722969; L-Glutamic acid, N-(4-(2-((6R)-2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-d)pyrimidin-6-yl)ethyl)benzoyl)-, disodium salt. Grades: 98%. CAS No. 120408-07-3. Molecular formula: C21H23N5Na2O6. Mole weight: 487.42. | |
| Lometrexol hydrate | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
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