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| Product | Description | |
|---|---|---|
| Longdaysin | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Longdaysin | A cell-permeable purine compound that acts as a reversible and ATP-competitive dual inhibitor of CKI? and CKI? activities with moderate selectivity over Cdk7 and Erk2. Group: Fluorescence/luminescence spectroscopy. | |
| Longdaysin (Casein Kinase I Inhibitor VII, 9-Isopropyl-N- (3- (trifluoromethyl) benzyl) -9H-purin-6-amine) | A cell-permeable purine compound that acts as a reversible and ATP-competitive dual inhibitor of CKIa and CKId activities (IC50 = 5.6 and 8.8uM) with moderate selectivity over Cdk7 and Erk2 (IC50 = 29 and 52uM). Shown to block CKIa/d-mediated phosphorylation of PER1, a clock protein, (IC50 ~9uM) and repress PER1 proteasomal degradation, and lengthen the circadian period in U2OS cells (by ~13hrs at 10uM) much more effectively than Casein Kinase I Inhibitor, D4476 and IC261 and in larval zebra fish. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
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