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| Product | Description | |
|---|---|---|
| Longdaysin | Longdaysin is an inhibitor of protein kinases including CKIδ, CKIα, ERK2 and CDK7 with IC50 values of 8.8 μM, 5.6 μM, 52 μM and 29 μM, respectively. Longdaysin inhibits Wnt/β-catenin signaling pathway and exhibits antitumor activity. Synonyms: 9-Isopropyl-N-(3-(trifluoromethyl)benzyl)-9H-purin-6-amine. CAS No. 1353867-91-0. Molecular formula: C16H16F3N5. Mole weight: 335.33. |  |
| Longdaysin (Casein Kinase I Inhibitor VII, 9-Isopropyl-N- (3- (trifluoromethyl) benzyl) -9H-purin-6-amine) | A cell-permeable purine compound that acts as a reversible and ATP-competitive dual inhibitor of CKIa and CKId activities (IC50 = 5.6 and 8.8uM) with moderate selectivity over Cdk7 and Erk2 (IC50 = 29 and 52uM). Shown to block CKIa/d-mediated phosphorylation of PER1, a clock protein, (IC50 ~9uM) and repress PER1 proteasomal degradation, and lengthen the circadian period in U2OS cells (by ~13hrs at 10uM) much more effectively than Casein Kinase I Inhibitor, D4476 and IC261 and in larval zebra fish. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
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