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| Product | Description | |
|---|---|---|
| LRRK2-IN-1 | LRRK2-IN-1 Inhibitor. Uses: Scientific use. Product Category: T2246. CAS No. 1234480-84-2. |  |
| LRRK2-IN-1 | LRRK2-IN-1 is a benzodiazepine based derivative and is known as a selective inhibitor of the Parkinson's disease kinase LRRK2. Group: Biochemicals. Alternative Names: 5, 11-Dihydro-2- [ [2-methoxy-4- [ [4- (4-methyl-1-piperazinyl) -1-piperidinyl] carbonyl] phenyl] amino] -5, 11-dimethyl-6H-pyrimido [4, 5-b] [1, 4] benzodiazepin-6-one. Grades: Highly Purified. CAS No. 1234480-84-2. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| LRRK2-IN-1 | LRRK2-IN-1 is a potent and selective LRRK2 inhibitor with IC 50 of 6 nM and 13 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1234480-84-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-10875. |  |
| LRRK2 Inhibitor III, HG-10-102-01 (Leucine-Rich Repeat Kinase 2 Inhibitor III, Mixed-Lineage Kinase 1 Inhibitor I, MLK1 Inhibitor I, MNK Inhibitor III, (4- (5-Chloro-4- (methylamino)pyrimidin-2-ylamino)-3-methoxyphenyl) (morpholino)methanone) | A cell-permeable 2,4-diaminopyrimidinyl compound that acts as a potent, ATP-competitive LRRK2-selective inhibitor (IC5050 = 20.3, 3.2, 153.7 and 95.9nM, respectively,against human wt LRRK2 and G2019S, A2016T, G2019S/A2016T LRRK2 mutant; [ATP] = 100uM), displaying much reduced potency against MNK2 and MLK1 (IC50 = 0.6 and 2.1uM, respectively; [ATP] = 100uM) and little activity toward a panel of 136 other kinases. Although both HG-10-102-01 and LRRK2-In-1 inhibit cellular wt and G20195 LRRK2 phosphorylation (Optimal conc. 1 to 3uM), only HG-10-102-01 is effective against cellular A2016T and G2019S/A2016T LRRK2 phosphorylations (IC50 <3uM). And only HG-10-102-01, but not LRRK2-In-1 or CZC-25146, can cross blood-brain-barrier for LRRK2 phosphorylation inhibition in mice (30mg/kg to 50mg/kg i.p.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??ClN?O?. US Biological Life Sciences. | Worldwide |
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