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| Product | Description | |
|---|---|---|
| LTV-1 | LTV-1, a highly potent inhibitor, inhibits LYP((IC50 = 508 nM)) in a dose-dependent manner at low- and sub-micromolar concentrations in T cells. Uses: Potent, cell-permeable and reversible inhibitor of lymphoid tyrosine phosphatase. Synonyms: LTV-1; LTV 1; LTV1; 3-[ (4-{ (E) -[1- (2-Methylphenyl) -4, 6-dioxo-2-thioxotetrahydro-5 (2H) -pyrimidinylidene]methyl}phenoxy) methyl]benzoic acid. Grades: ≥98%. CAS No. 347379-29-7. Molecular formula: C26H20N2O5S. Mole weight: 472.51. |  |
| LYP Inhibitor II, LTV-1 (Lymphoid Tyrosine Phosphatase Inhibitor II, LTV-1, (E) -3- ( (4- ( (4, 6-Dioxo-2-thioxo-1-o-tolyltetra hydropyrimidin-5 (6H) -ylide ne ) methyl ) phenoxy) methyl ) benzoic Acid) | A cell-permeable thiobarbituryl-benzoate compound that acts as a highly potent and reversible inhibitor of lymphoid tyrosine phosphatase (LYP) (IC50=508nM) and thereby enhances TCR signaling in intact cells. Exhibits competitive to mixed mode of inhibition (Ki=384nM). Also shown to inhibit the mutant, disease associated LYP-Trp620 activity. Binds to the phosphate-binding loop and mimicks the phosphotyrosine moiety of substrates. Displays acceptable selectivity over a wide range of protein phosphatases (TCPTP, PTP1B, PEP (mouse LYP), SHP1, CD45 and PTP-PEST: IC50=1.52, 1.59, 7.56, 23.2, 30.1, and 100uM, respectively). Does not exhibit any toxicity at pharmacological doses when tested in primary human cell lines. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
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