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| Product | Description | |
|---|---|---|
| Lucanthone | Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 ( APE-1 ). Uses: Scientific research. Group: Signaling pathways. CAS No. 479-50-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B2098. |  |
| Lucanthone | Lucanthone is orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1 (APEX1 or APE1), with anti-schistosomal and potential antineoplastic activity. Lucanthone intercalates DNA and interferes with the activity of topoisomerases I and II during replication and transcription, thereby inhibiting the synthesis of macromolecules. In addition, this agent specifically inhibits the endonuclease activity of APE1, without affecting its redox activity, resulting in unrepaired DNA strand breaks which may induce apoptosis. Therefore, lucanthone may sensitize tumor cells to radiation and chemotherapy. Furthermore, lucanthone inhibits autophagy through the disruption of lysosomal function. The multifunctional nuclease APE1 is a key component for DNA repair; its expression is often correlated with tumor cell resistance to radio- and chemotherapy. Uses: Schistosomicides. Synonyms: Lucanthonum; 1-{[2-(Diethylamino)ethyl]amino}-4-methyl-9H-thioxanthen-9-one; CCRIS 1106. CAS No. 479-50-5. Molecular formula: C20H24N2OS. Mole weight: 340.48. |  |
| Lucanthone Hydrochloride | Anthelmintic (Schistosoma). Group: Biochemicals. Alternative Names: 1-[[2- (Diethylamino) ethyl]amino]-4-methyl-9H-thioxanthen-9-one Hydrochloride; BW 57-233; Lucanthone MonoHydrochloride; Miracil D; Miracol; Ms. 752; NSC 14574; Nilodin; RP 3735; Scapuren; Tixantone. Grades: Highly Purified. CAS No. 548-57-2. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Hycanthone | Hycanthone is a thioxanthenone DNA intercalator and inhibits RNA synthesis as well as the DNA topoisomerases I and II. Hycanthone inhibits nucleic acid biosynthesis and inhibits apurinic endonuclease-1 (APE1) by direct protein binding with a K D of 10 nM. Hycanthone is a bioactive metabolite of Lucanthone (HY-B2098) and has anti-schistosomal agent [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3105-97-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-B1099. | |
| Hycanthone | Hycanthone is the active metabolite of the anthelmintic prodrug Lucanthone, which is used in the treatment of schistosomiasis. Hycanthone inhibits nucleic acid biosynthesis and inhibits apurinic endonuclease-1 (APE1) by direct protein binding with a KD of 10 nM. Synonyms: 1-[[2-(Diethylamino)ethyl]amino]-4-(hydroxymethyl)-9H-thioxanthen-9-one; 1-[[2-(Diethylamino)ethyl]amino]-4-(hydroxymethyl)thioxanthen-9-one; Hycanthon; NCI 142982; NSC 134434; NSC 142982; Win 24933. CAS No. 3105-97-3. Molecular formula: C20H24N2O2S. Mole weight: 356.48. | |
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