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| Product | Description | |
|---|---|---|
| LX7101 | LX7101 is a pyrrolopyrimidine-based, topically-delivered inhibitor of LIM domain kinase 2 (LIMK2), a kinase associated with the regulation of intraocular pressure. It is also a ROCK inhibitor used for the treatment of glaucoma. LX7101 acts by enhancing fl. Uses: Lx7101 is a lim domain kinase 2 (limk2) inhibitor which could be probably effective in the treatment of glaucoma. Synonyms: 3-(4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)phenyl dimethylcarbamate hydrochloride. Grades: > 95%. CAS No. 1192189-69-7. Molecular formula: C23H30ClN7O3. Mole weight: 487.99. |  |
| LX7101 hydrochloride | LX7101 is a dual inhibitor of LIM kinase (LIMK) and Rho-associated kinase (ROCK) with IC50 values of 32, 4.3, 69, and 32 nM for LIMK1, LIMK2, ROCK1 and ROCK2, respectively. It has been identified as a candidate for the treatment of ocular hypertension and associated glaucoma due to its high efficacy and good safety profile. Synonyms: LX7101 HCl; [3-[[4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]phenyl] N,N-dimethylcarbamate hydrochloride. Grades: ≥98%. Molecular formula: C23H29N7O3·HCl. Mole weight: 488. | |
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