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| Product | Description | |
|---|---|---|
| LY-411575 | ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| LY-411575 | LY-411575, also known as LSN-411575, is a potent, cell-permeable γ-secretase inhibitor (IC50 = 0.078 nM/0.082 nM in membrane-assay/in cell-basedγ-secretase assays) and also inhibits Notch clevage (IC50 = 0.39 nM). Synonyms: LY 411575; LY-411575; LY411575; LSN-411575; LSN 411575; LSN411575. (2S)-2-[[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide; LY 411,575; LY 411575; LY 450139; LY-411,575; LY-411575; LY411,575; LY411575; LY450139; N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide; N2-(2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)alaninamide; Semagacestat; 209984-57-6. Grades: >98%. CAS No. 209984-57-6. Molecular formula: C26H23F2N3O4. Mole weight: 479.48. |  |
| LY-411575 isomer 1 | LY-411575 isomer 1, is an isomer of LY411575, which is a potent, cell-permeable γ-secretase inhibitor (IC50 = 0.078 nM/0.082 nM in membrane-assay/in cell-based γ-secretase assays) and also inhibits Notch clevage (IC50 = 0.41 nM). Synonyms: LY 411575 isomer 1; LY411575 isomer 1; (2S)-2-[[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide; LY-411575 (isomer 1); HY-50752A; ZINC38382410; CS-3132; 209984-58-7. CAS No. 209984-58-7. Molecular formula: C26H23F2N3O4. Mole weight: 479.48. | |
| LY-411575 isomer 2 | LY-411575 isomer 2 is an isomer of LY411575, which is a potent and cell-permeable γ-secretase inhibitor with IC50s of 0.078 and 0.082 nM in membrane-assay and cell-based γ-secretase assays, respectively. LY411575 also inhibits Notch clevage with an IC50 of 0.41 nM. Synonyms: N2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyacetyl]-N-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-D-alaninamide; Benzeneacetamide, N-[(1R)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-α-hydroxy-, (αS)-; LY411575 isomer 2; LY 411575 isomer 2. Grades: ≥98%. CAS No. 2070009-70-8. Molecular formula: C26H23F2N3O4. Mole weight: 479.48. | |
| LY-411575 isomer 3 | LY-411575 isomer 3 is an isomer of LY411575, which is a potent and cell-permeable γ-secretase inhibitor with IC50s of 0.078 and 0.082 nM in membrane-assay and cell-based γ-secretase assays, respectively. LY411575 also inhibits Notch clevage with an IC50 of 0.41 nM. Synonyms: N2-[(2R)-2-(3,5-Difluorophenyl)-2-hydroxyacetyl]-N-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-D-alaninamide; Benzeneacetamide, N-[(1R)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-α-hydroxy-, (αR)-; LY411575 isomer 3; LY 411575 isomer 3. Grades: ≥98%. CAS No. 2070009-28-6. Molecular formula: C26H23F2N3O4. Mole weight: 479.48. | |
| LY-411575 (LY 411575, LY411575, Semagacestat) | LY-411575 (LY 411575, LY411575, Semagacestat). Group: Biochemicals. Alternative Names: (2S)-2-[[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide. Grades: Highly Purified. CAS No. 209984-57-6. Pack Sizes: 25mg. Molecular Formula: C26H23F2N3O4, Molecular Weight: 479.5. US Biological Life Sciences. |  Worldwide |
| Deshydroxy LY-411575 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| DBZ | DBZ, also called dibenzazepine, is a γ-secretase inhibitor to treat Alzheimer's Disease, and it also inhibits Notch signaling. Synonyms: YO-01027; YO 01027; YO01027; (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide; dibenzazepine; GSI XX; Dibenzazepine; 209984-56-5; YO-01027; (S)-2-(2-(3,5-Difluorophenyl)acetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanamide; Deshydroxy LY 411575; gamma-Secretase Inhibitor XX; DBZ; 209984-56-5 pound not YO 01027; (S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide; N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide; C26H23F2N3O3; GSI-XX; g-secretase inhibitor XX; Gamma-secretase inhibitor; Deshydroxy LY-411514; Deshydroxy LY-411575; MLS006011073; SCHEMBL3046688; DTXSID6040458; AOB1375; ANW-62574; ZINC22056928; AKOS016004347; RL02593; YO01027; NCGC00263188-01; AC-27417; AJ-80844; AK101890; BC638679; SMR004676467; AB0033830; KB-210919; TC-151319; FT-0666470; ST24035862; X7602; Z-3141; (2S)-2-[2-(3,5-. Grades: >98%. CAS No. 209984-56-5. Molecular formula: C26H23F2N3O3. Mole weight: 463.48. | |
| Semagacestat | Semagacestat is an inhibitor of the γ-secretase complex that blocks the production of Aβ38 (IC50= 12.0 nM), Aβ40 (IC50= 12.1 nM), and Aβ42 (IC50= 10.9 nM) from H4 human glioma cells stably overexpressing human wild-type APP into the culture medium. In vitro: blocks the production of Aβ38 (IC50= 12.0 nM), Aβ40 (IC50= 12.1 nM), and Aβ42 (IC50= 10.9 nM) without affecting cell viability. In vivo: decreases hippocampal levels of both Aβ42 and Aβ40 at 10 mg/kg (22-23% reduction) and 30 mg/kg (36-41% reduction) and increases β-CTF at 0.3-10 mg/kg in a dose dependent manner with no inhibition on the processing of other γ-secretase substrates, such as Notch, N-cadherin or EphA4, in the brain, but impairs normal cognition in wild-type mice and 3-month-old Tg2576 mice failing to restore cognitive deficits in the Y-maze test. Uses: Gamma secretase inhibitors and modulators. Synonyms: (2S)-2-hydroxy-3-methyl-N-[(2S)-1-[[(5S)-3-methyl-4-oxo-2,5-dihydro-1H-3-benzazepin-5-yl]amino]-1-oxopropan-2-yl]butanamide; LY 411,575; LY 411575; LY 450139; LY-411,575; LY-411575; LY411,575; LY411575; LY450139; N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide; N2-(2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)alaninamide; LY4501; LY-4501; LY 4501; LY450139; LY-450139; LY 450139; Semagacestat. 425386-60-3. Grades: >98%. CAS No. 425386-60-3. Molecular formula: C19H27N3O4. Mole weight: 361.44. | |
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