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| Product | Description | |
|---|---|---|
| MAK683 | MAK683 is an embryonic ectoderm development ( EED ) inhibitor extracted from patent US20160176882 A1, compound example 2. MAK683 exhibits IC 50 s of 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1951408-58-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103663. |  |
| MAK683 | MAK683 is an inhibitor of embryonic ectoderm development protein (EED) with potential antineoplastic activity. MAK683 binds to the domain of EED that interacts with trimethylated lysine 27 on histone 3 (H3K27me3), leading to a conformational change in the EED H3K27me3-binding pocket and preventing the interaction of EED with the histone methyltransferase enhancer zeste homolog 2 (EZH2). MAK683 is undergoing phase II clinical trials for the identification of antitumor activity. Synonyms: MAK-683; MAK 683; MAK683; EED inhibitor-1; N-[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine. Grades: 98%. CAS No. 1951408-58-4. Molecular formula: C20H17FN6O. Mole weight: 376.395. |  |
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