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| Product | Description | |
|---|---|---|
| Mardepodect | Mardepodect (PF-2545920) is a potent, orally active and selective PDE10A inhibitor with an IC 50 of 0.37 nM, with >1000-fold selectivity over other PDEs. Mardepodect can cross the blood-brain barrier [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-2545920. CAS No. 898562-94-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50098. |  |
| Mardepodect free base | Mardepodect, also known as PF-2545920, is a phosphodiesterase inhibitor selective for the PDE10A subtype, which is potentially useful for the treatment of schizophrenia. Phosphodiesterase 10A (PDE10A) is highly expressed in striatal medium spiny neurons of both the direct and indirect output pathways. PDE10A inhibitors have shown behavioral effects in rodent models that predict antipsychotic efficacy. PF-2545920 is active in a range of antipsychotic models, antagonizing apomorphine-induced climbing in mice, inhibiting conditioned avoidance responding in both rats and mice, and blocking N-methyl-D-aspartate antagonist-induced deficits in prepulse inhibition of acoustic startle response in rats, while improving baseline sensory gating in mice. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PF-2545920; PF 2545920; PF2545920; MP-10; MP10; MP 10, Mardepodect. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 898562-94-2. Molecular formula: C25H20N4O. Mole weight: 392. Purity: >98%. IUPACName: 2-(4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxymethyl)quinoline. Canonical SMILES: CN1N=C(C2=CC=C(OCC3=NC4=CC=CC=C4C=C3)C=C2)C(C5=CC=NC=C5)=C1. Product ID: ACM898562942. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Mardepodect hydrochloride | Mardepodect hydrochloride (PF-2545920 hydrochloride) is a potent, orally active and selective PDE10A inhibitor with an IC 50 of 0.37 nM, with >1000-fold selectivity over other PDEs. Mardepodect hydrochloride can cross the blood-brain barrier [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-2545920 hydrochloride. CAS No. 2070014-78-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50098A. | |
| PF-2545920 | PF-2545920 a highly selective and potent PDE10A inhibitor. It was active with an ED50 of 1 mg/kg. Synonyms: PF-2545920; PF 2545920; PF2545920; MP-10; MP10; MP 10, Mardepodect. Grades: >98%. CAS No. 898562-94-2. Molecular formula: C25H20N4O. Mole weight: 392.45. |  |
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