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| Product | Description | |
|---|---|---|
| methionine adenosyltransferase | S-adenosylmethionine synthetase (EC 2.5.1.6) (also known as methionine adenosyltransferase (MAT)) is an enzyme that creates S-adenosylmethionine (a.k.a. AdoMet, SAM or SAMe) by reacting methionine (a non-polar amino acid) and ATP (the basic currency of energy). Group: Enzymes. Synonyms: adenosylmethionine synthetase; ATP-methionine adenosyltransferase; methionine S-adenosyltransferase; methionine-activating enzyme; S-adenosyl-L-methionine synthetase; S-adenosylmethionine synthase; S-adenosylmethionine synthetase; AdoMet synthetase. Enzyme Commission Number: EC 2.5.1.6. CAS No. 9012-52-6. MAT. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2797; methionine adenosyltransferase; EC 2.5.1.6; 9012-52-6; adenosylmethionine synthetase; ATP-methionine adenosyltransferase; methionine S-adenosyltransferase; methionine-activating enzyme; S-adenosyl-L-methionine synthetase; S-adenosylmethionine synthase; S-adenosylmethionine synthetase; AdoMet synthetase. Cat No: EXWM-2797. |  |
| 2-Amino-4-phenoxybutanoic Acid | 2-Amino-4-phenoxybutanoic Acid has inhibitory effects on ATP:L-methionine S-adenosyltransferase in rat liver. Group: Biochemicals. Grades: Highly Purified. CAS No. 52161-80-5. Pack Sizes: 50mg, 100mg. Molecular Formula: C10H13NO3, Molecular Weight: 195.22. US Biological Life Sciences. |  Worldwide |
| 3-TYP | 3-TYP is an inhibitor of SIRT3 (IC50of 38 ?M) and an inhibitor of Methionine Adenosyltransferase (MAT) 2 and Indoleamine 2,3-Dioxygenase (IDO). There may be many off-target sites for 3-TYP that need to be examined, such as NAD-dependent enzymes, including dehydrogenases[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 120241-79-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108331. |  |
| AGI-24512 | AGI-24512 is a potent methionine adenosyltransferase 2? (MAT2A) inhibitor, with an IC50 of 8 nM. AGI-24512 triggers DNA damage response. AGI-24512 can block proliferation of MTAP-deleted cancer cells in vitro. AGI-24512 can be used for researching anticancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2201066-53-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-112130. | |
| AGI25696-Analog | AGI25696-Analog is a demethyl analog of AGI-25696, which is a methionine adenosyltransferase 2A (MATA2 ) inhibitor. AGI-25696 is potentially useful for treatment of cancer. AGI-25696 blocks growth of MTAP-deleted tumors in vivo. Note: The correct structure of AGI-25696 is CAS#2201065-84-9. Many vendors mistakenly listed CAS#2201066-35-3 as its AGI25696. J. Med. Chem. 2021, 64, 8, 4430-4449 published AGI25696 structure (it is CAS#2201065-84-9). Uses: Designed for use in research and industrial production. Additional or Alternative Names: AGI25696-Analog, AGI-25696-demethyl; AGI 25696-demethyl; AGI25696-demethyl. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2201066-35-3. Molecular formula: C27H18N4O. Mole weight: 414.47. Purity: >98%. IUPACName: 2,3-diphenyl-6-(quinolin-6-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one. Canonical SMILES: O=C1C(C2=CC=C3N=CC=CC3=C2)=CNC4=C(C5=CC=CC=C5)C(C6=CC=CC=C6)=NN14. Product ID: ACM2201066353. Alfa Chemistry ISO 9001:2015 Certified. |  |
| aminodeoxyfutalosine synthase | This enzyme is a member of the 'AdoMet radical' (radical SAM) family. S-Adenosyl-L-methionine acts as both a radical generator and as the source of the transferred adenosyl group. The enzyme, found in several bacterial species, is part of the futalosine pathway for menaquinone biosynthesis. Group: Enzymes. Synonyms: MqnE; AFL synthase; aminofutalosine synthase; S-adenosyl-L-methionine:3-[(1-carboxyvinyl)-oxy]benzoate adenosyltransferase (bicarbonate-hydrolysing, 6-amino-6-deoxyfutalosine-forming). Enzyme Commission Number: EC 2.5.1.120. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2736; aminodeoxyfutalosine synthase; EC 2.5.1.120; MqnE; AFL synthase; aminofutalosine synthase; S-adenosyl-L-methionine:3-[(1-carboxyvinyl)-oxy]benzoate adenosyltransferase (bicarbonate-hydrolysing, 6-amino-6-deoxyfutalosine-forming). Cat No: EXWM-2736. | |
| Cycloleucine | Cycloleucine is a competitive inhibitor of glycine modulatory site of N-methyl-D-aspartate (NMDA) receptor, with immunosuppressive, antineoplastic and cytostatic activities. It competitively inhibits methionine adenosyltransferase, thereby inhibiting S-adenosylmethionine (SAM) synthesis from methionine and ATP, and subsequent nucleic acid methylation and polyamine production. Synonyms: 1-Aminocyclopentanecarboxylic acid; 1-Amino-1-cyclopentanecarboxylic acid; 1-Amino-1-carboxycyclopentane; NSC 1026; NSC 112194; NSC 112195; NSC 112197; ACPC. Grade: ≥98%. CAS No. 52-52-8. Molecular formula: C6H11NO2. Mole weight: 129.16. |  |
| FIDAS-5 | FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 ?M. FIDAS-5 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-5 has anticancer activities[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1391934-98-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136144. | |
| MAT2A Inhibitor II, FIDAS-5 | A cell-permeable fluorinated N,N-dialkylaminostilbene (FIDAS) analogue of FIDAS-3 that competes against SAM for MAT2A binding and is >2-fold more potent than FIDAS-3 in inhibiting MAT2A-catalyzed SAM synthesis both in cell-free assays (IC50 = 2.1uM) and in LS174T colorectal cancer (CRC) cultures (3uM). FIDAS-5 at 3uM is shown to completely inhibit the proliferation of LS174T for up to 7 d in vitro and effectively suppress HT29 CRC tumor expansion in mice in vivo (20mg/kg/day p.o.). Group: Biochemicals. Alternative Names: FIDAS5; Methionine S-Adenosyltransferase 2A Inhibitor II; (E)-4-(2-Chloro-6-fluorostyryl)-N-methylaniline. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C15H13CIFN, Molecular Weight: 261.73. US Biological Life Sciences. | Worldwide |
| PF-9366 | PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor, with an IC50 of 420 nM and a Kd of 170 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 72882-78-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107778. | |
| S-Adenosyl-L-methionine tosylate | S-Adenosyl-L-methionine tosylate is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine tosylate is a dietary supplement with potent antidepressant and analgesic effects, and has the potential for liver disease and osteoarthritis research [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: S-Adenosyl methionine tosylate; Ademetionine tosylate; AdoMet tosylate. CAS No. 52248-03-0. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 500 mg. Product ID: HY-B0617A. | |
| S-adenosylmethionine synthetase, Recombinant | S-adenosylmethionine synthetase (EC 2.5.1.6) (also known as methionine adenosyltransferase (MAT)) is an enzyme that creates S-adenosylmethionine (AdoMet) by reacting methionine (a non-polar amino acid) and ATP (the basic currency of energy). AdoMet is a methyl donor for transmethylation. It gives away its methyl group and is also the propylamino donor in polyamine biosynthesis. S-adenosylmethionine synthetasecan be considered the rate-limiting step of the methionine cycle. S-adenosylmethionine (sam) is a methyl donor and allows dna methylation. once dna is methylated, it switches the genes off and therefore, s-adenosylmethionine can be considered tocontrol gene expressi...denosylmethioninesynthase isoform type-1; AdoMet synthase 1; MAT 1; Methionineadenosyltransferase I/III; MAT-I/III; MAT1A; AMS1. Enzyme Commission Number: EC 2.5.1.6. Purity: >90% (SDS-PAGE test). Mole weight: About 46kDa (SDS-PAGE detection). Activity: >700U/mg. Appearance: White powder, lyophilized. Storage: Redissolved in 30% glycerol, 4°C, store at -20°C/-80°C for long-term preservation, Avoid multiple freeze-thaw cycles. Form: Freeze dried powder. EC 2.5.1.6; MAT; MATA1; SAMS; SAMS1; Methionine adenosyltransferase 1; S-adenosylmethioninesynthase isoform type-1; AdoMet synthase 1; MAT 1; Methionineadenosyltransferase I/III; MAT-I/III; MAT1A; AMS1. Cat No: NATE-1151. | |
| Seleno-D,L-ethionine | Used as a substrate for methionine adenosyltransferase from rat liver. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
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