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Methotrexate EP Impurity C An impurity of Methotrexate, an antimetabolite and immunosuppressant used in chemotherapy and auto-immune diseases. Synonyms: Methopterine; N-[4-[[ (2-Amino-3, 4-dihydro-4-oxo-6-pteridinyl) methyl]methylamino]benzoyl]-L-glutamic Acid; N-[p-[[ (2-Amino-3, 4-dihydro-4-oxo-6-pteridinyl) methyl]methylamino]benzoyl]-L-glutamic Acid; N-[p-[[ (2-Amino-4-hydroxy-6-pteridinyl) methyl]methylamino]benzoyl]glutamic Acid; N-[4-[[ (2-Amino-1, 4-dihydro-4-oxo-6-pteridinyl) methyl]methylamino]benzoyl]-L-glutamic Acid; 10-Methylfolic Acid; N10-Methyl Folic Acid; 10-Methylpteroylglutamic Acid; N10-Methylpteroylglutamic Acid; Methotrexate USP Related Compound C; Methotrexate Related Compound C; (4-(((2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid. Grades: 96%. CAS No. 2410-93-7. Molecular formula: C20H21N7O6. Mole weight: 455.42. BOC Sciences 6
Methotrexate EP Impurity I Sodium Salt Methotrexate EP Impurity I Sodium Salt is one of methotrexate impurities. Methotrexate is a Folic Acid antagonist, used as an antineoplastic and antirheumatic. Synonyms: Methotrexate-1-(Monomethyl Ester Sodium Salt). Molecular formula: C21H23N8O5.Na. Mole weight: 490.45. BOC Sciences 6
Methotrexate EP Impurity L An impurity of Methotrexate, an antimetabolite and immunosuppressant used in chemotherapy and auto-immune diseases. This impurity also acts as an inhibitor of human DNA methyltransferase. Synonyms: N-(4-(Methylamino)benzoyl)-L-glutamic acid; N-(p-(Methylamino)benzoyl)glutamic acid; (p-Methylaminobenzoyl)-L-glutamic Acid; N-[p-(Methylamino)benzoyl]-L-glutamic acid; NSC 138419. Grades: > 95%. CAS No. 52980-68-4. Molecular formula: C13H16N2O5. Mole weight: 280.28. BOC Sciences 8
(2S) -2- (4- (4- ( ( (2, 4-diaminopteridin-6-yl) methyl) (methyl) amino) -N-methylbenzamido) benzamido) pentanedioic Acid (2S) -2- (4- (4- ( ( (2, 4-diaminopteridin-6-yl) methyl) (methyl) amino) -N-methylbenzamido) benzamido) pentanedioic Acid is one of methotrexate impurities. Methotrexate is a Folic Acid antagonist, used as an antineoplastic and antirheumatic. Synonyms: Methotrexate Impurity G; Methotrexate EP Impurity G. Molecular formula: C28H29N9O6. Mole weight: 587.59. BOC Sciences 6

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