Methyltransferase Suppliers USA
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Product | Description | |
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AMI-1 (Arginine N-methyltransferase Inhibitor-1) (Sodium Salt) Quick inquiry Where to buy Suppliers range | PRMT1,3,4 & 6 Inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
CARM1 Inhibitor (1-Benzyl-3, 5-bis- (3-bromo-4-hydroxybenzylidene) piperidin-4-one, 3,5-bis(3-Bromo-4-hydroxybenzylidene)-1-benzylpiperidin-4-one, Coactivator-Associated Arginine Methyltransferase 1 Inhibitor, PRMT Inhibitor V) Quick inquiry Where to buy Suppliers range | A cell-permeable (bis-benzylidene) piperidinone compound that acts as a selective inhibitor against CARM1/PRMT4 arginine methyltransferase activity (IC50=7.1uM with PABP1 as substrate). It inhibits PRMT3 only at much higher concentrations (by 70% and 62% with 100uM inhibitor using NPL3 or rpS2 as substrate, respectively), exhibiting little activity against PRMT1, PRMT5, PRMT6 (IC50>100uM), or four HKMTs (<20% inhibition against DOTL1, G9a, SET7, or Suv39H1 with 100uM inhibitor). Shown to inhibit PSA promoter-mediated reporter transcription in LNCaP cells in a dose-dependent manner (by 74% and 97%, respectively, with 4 and 6uM inhibitor). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Chaetocin, Lys Methyltransferase Inhibitor Quick inquiry Where to buy Suppliers range | Lys methyltransferase inhibitor. Inhibits the lysine methyltransferase SU (VAR)3-9. Displays antimyeloma activity in IL-6-dependent myeloma cell lines. Cell permeable. Group: Biochemicals. Grades: Highly Purified. CAS No. 28097-03-2. Pack Sizes: 200ug. US Biological Life Sciences. | Worldwide |
Decitabine, DNA Methyltransferase Inhibitor. (5-Aza-2-deoxycytidine; NSC-127716, 2'-Deoxy-5-azacytidine; 4-Amino-1-(2-deoxy-B-D-erythropentofuranosyl)-1,3,5-triazin-2(1H)-one) Quick inquiry Where to buy Suppliers range | Inhibits DNA methyltransferase. Induces demethylation and reactivation of silenced genes. Group: Biochemicals. Alternative Names: 5-Aza-2-deoxycytidine; NSC-127716, 2'-Deoxy-5-azacytidine; 4-Amino-1-(2-deoxy-B-D-erythropentofuranosyl)-1,3,5-triazin-2(1H)-on. Grades: Highly Purified. CAS No. 2353-33-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
DNA Methyltransferase Inhibitor V, RSC133 (DNA MTase Inhibitor V, (E) -3- (3- (1H-Indol-3-yl) acrylamido) benzamide, ID133, iPSC Induction Enhancer III, Reprogramming Stimulating Compound 133) Quick inquiry Where to buy Suppliers range | A cell-permeable indolylacrylamido-benzamide compound that is reported to target Dnmt1 at the cofactor SAM-binding site and enhance the efficiency of iPSC production from both murine MEF (10uM starting 5 d post KSOM viral infection) and human foreskin fibroblast (10uM starting same day as or 5 d post KSOM viral infection) cultures with accompanying cellular Dnmt1 activity reduction, affecting hFF viability only at high concentrations (78% of control post 72h 100uM treatment). Also shown to help maintain H9 hESCs in undifferentiated state when cultured in unconditioned media (10uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??N?O?, Primary Target: Dnmt1. US Biological Life Sciences. | Worldwide |
Histidine protein methyltransferase 1 homolog (142-156) Quick inquiry Where to buy Suppliers range | Histidine protein methyltransferase 1 homolog. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-160. | |
Histone-lysine N-methyltransferase EZH2 (120-128) Quick inquiry Where to buy Suppliers range | Histone-lysine N-methyltransferase EZH2. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-324. | |
Histone-lysine N-methyltransferase EZH2 (165-174) Quick inquiry Where to buy Suppliers range | Histone-lysine N-methyltransferase EZH2. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-325. | |
Histone-lysine N-methyltransferase EZH2 (291-299) Quick inquiry Where to buy Suppliers range | Histone-lysine N-methyltransferase EZH2. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-326. | |
Histone-lysine N-methyltransferase EZH2 (735-743) Quick inquiry Where to buy Suppliers range | Histone-lysine N-methyltransferase EZH2. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-327. | |
Histone Methyltransferase EZH2 Inhibitor, DZNep (3-deazaneplanocin A, HCl, (1S, 2R, 5R) -5- (4-amino-1H-imidazo[4, 5-c]pyridin-1-yl) -3- (hydroxymethyl) cyclopent-3-ene-1, 2-diol, HCl, HMTase Inhibitor X) Quick inquiry Where to buy Suppliers range | A cell-permeable compound that is shown (at 1uM concentrations) to inhibit EZH2-mediated trimethylation of K27 on histone H3 and induces the expression of cell-cycle regulatory genes, p21 and p27, as well as the cell death regulator, FBXO32, in OCI-AML3 and HL-60 cells, whereby treatment with inhibitor increases p16 levels in the former, but not the latter of the two cultures. At concentrations between 200nM and 2000nM, this compound is found to dose-dependently deplete the expression of polycomb group proteins EZH2, SUZ12, and EED in cultured and primary AML cell extracts. At concentrations up to ≥ 1000nM, DZNep dose-dependently increases the percentage of apoptotic cells up to > ~ 38%, with greater potency against OCI-AML3 than HL-60 cultures and inhibits colony growth up to > ~ 85% for both cell lines. In OCI-AML3 cultures, 1000nM of treatment demonstrates a significant increase in the accumulation of cells in the G0/G1 phase (58.5%) with a concomitant decrease in the number of c Group: Biochemicals. Grades: Highly Purified. CAS No. 102052-95-9. Pack Sizes: 2mg. Molecular Formula: C??H??N?O?; HCl; H?O. US Biological Life Sciences. | Worldwide |
HMTase Inhibitor IX, MM-102 (Histone Methyltransferase Inhibitor IX, MM102, (S) -N- (bis (4-Fluoro phenyl ) methy l )-1- (2- (2-ethyl -2-isobutyramidobutanamid o)-5-guanidinopentanamido) cyclopentane carboxami de , TFA) Quick inquiry Where to buy Suppliers range | A cell-permeable peptidomimetic that prevents MLL1 (Mixed Lineage Leukemia 1) from complex assembling with WDR5 (Trp-Asp Repeat Domain 5), RbBP5 (Retinoblastoma Binding Protein 5), and ASH2L (Absent Small or Homeotic-2-Like) for enhanced H3K4 methyltransferase activity (IC50 = 0.4nM). Shown to reduce HoxA9 and Meis-1 mRNA expression in myeloblasts derived from MLL1-AF9-transduced murine bone marrow cells (50uM for 96 h) and preferentially inhibit the growth of MLL1-AF4-harboring MV4;11 and MLL1-ENL-harboring KOPN8 leukemia cultures (GI50 in 7 days = 25uM) via apoptosis induction, while exhibiting much reduced potency against BCR-ABL-dependent K562 cells (GI50 in 7 days = 84uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O? · CF?CO?H. US Biological Life Sciences. | Worldwide |
HMTase Inhibitor V, UNC0224 (Histone Lysine Methyltransferase Inhibitor V, UNC0224, 7-(3-Dimethylaminopropoxy)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine, H2O) Quick inquiry Where to buy Suppliers range | A quinazolinamine compound that acts as a potent, reversible and SAM (S-adenosylmethionine) non-competitive inhibitor of methyltransferases G9a (H3K9 HMT/EHMT2; IC50=15nM; =23nM) and GLP (G9a-like protein/EHMT1; IC50=20nM). Displays 1,000-fold greater selectivity for G9a over SET7/9 (H3K4 HMTase), SET8/PreSET7 (H4K20 HMTase), PRMT3 (MTase) and JMJD2E (demethylase), and minimally affects the activities of a broad range of GPCRs, ion-channels and transporters in a 30-target selectivity panel, with the exception of muscarinic M2 receptor and histamine H1 receptors (82% and 31% inhibition at 1uM, respectively). Group: Biochemicals. Grades: Highly Purified. CAS No. 1197196-48-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
PRMT Inhibitor VI (1- (Benzo[d][1, 2, 3]thiadiazol-6-yl) -3- (2-cyclohexenylethyl) urea, 1-(1,2,3-Benzothiadiazol-6-yl)-3-[2-(1-cyclohexen-1-yl)ethyl]urea, Protein Arginine Methyltransferase Inhibitor VI) Quick inquiry Where to buy Suppliers range | A benzothiadiazolyl-cyclohexenylethylurea compound that binds to protein arginine methyltransferase 3 at the dimer interface and selectively inhibits PRMT3 activity in an allosteric manner (IC50 = 1.6uM), while being non-competitive with respect to AdoMet (S-adenosyl-L-methionine; SAM) or peptide substrates (Ki = 2.9 and 4.2 mM, respectively). Exhibits little or no inhibitory activity against PRMT1/4/5/8 or protein lysine methyltransferases, EHMT1, SUV39H2, SETD7, and SETD8, even at concentrations above 100uM. Although cell-permeable, it is metabolically unstable and therefore not recommended for cell cultures or in vivo applications. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?OS, Primary Target: PRMT3. US Biological Life Sciences. | Worldwide |
1,2,3,4-Tetrahydro-3-methylisoquinoline Hydrochloride Quick inquiry Where to buy Suppliers range | 1,2,3,4-Tetrahydro-3-methylisoquinoline Hydrochloride is a potent inhibitor of phenylethanolamine N-methyltransferase, an enzyme that catalyzes the formation of epinephrine. Group: Biochemicals. Grades: Highly Purified. CAS No. 112794-28-2. Pack Sizes: 250mg, 2.5g. Molecular Formula: C10H14ClN, Molecular Weight: 183.68. US Biological Life Sciences. | Worldwide |
1,2,3,4-Tetrahydro-4-methylisoquinoline Hydrochloride Quick inquiry Where to buy Suppliers range | 1,2,3,4-Tetrahydro-4-methylisoquinoline Hydrochloride is a potent inhibitor of phenylethanolamine N-methyltransferase, an enzyme that catalyzes the formation of epinephrine. Group: Biochemicals. Grades: Highly Purified. CAS No. 111661-47-3. Pack Sizes: 50mg, 500mg. Molecular Formula: C10H14ClN, Molecular Weight: 183.68. US Biological Life Sciences. | Worldwide |
1,2,3,4-Tetrahydro-5-methylisoquinoline Hydrochloride Quick inquiry Where to buy Suppliers range | 1,2,3,4-Tetrahydro-5-methylisoquinoline Hydrochloride is a potent inhibitor of phenylethanolamine N-methyltransferase, an enzyme that catalyzes the formation of epinephrine. Group: Biochemicals. Grades: Highly Purified. CAS No. 41565-80-4. Pack Sizes: 250mg, 1g. Molecular Formula: C10H14ClN, Molecular Weight: 183.68. US Biological Life Sciences. | Worldwide |
1,2,3,4-Tetrahydro-7-methylisoquinoline Hydrochloride Quick inquiry Where to buy Suppliers range | 1,2,3,4-Tetrahydro-7-methylisoquinoline Hydrochloride is a potent inhibitor of phenylethanolamine N-methyltransferase, an enzyme that catalyzes the formation of epinephrine. Group: Biochemicals. Grades: Highly Purified. CAS No. 41565-82-6. Pack Sizes: 100mg, 1g. Molecular Formula: C10H14ClN, Molecular Weight: 183.68. US Biological Life Sciences. | Worldwide |
1, 2, 3, 4-Tetrahydro-7- (trifluoromethyl) isoquinoline Hydrochloride Quick inquiry Where to buy Suppliers range | 1, 2, 3, 4-Tetrahydro-7- (trifluoromethyl) isoquinoline Hydrochloride are potent inhibitors of phenylethanolamine N-methyltransferase, enzyme involved in the biosynthesis of epinephrine. Group: Biochemicals. Grades: Highly Purified. CAS No. 220247-87-0. Pack Sizes: 25mg, 50mg. Molecular Formula: C10H10F3N HCl, Molecular Weight: 201.193646. US Biological Life Sciences. | Worldwide |
1,4-Dibenzoyl-3-thio-semicarbazide Quick inquiry Where to buy Suppliers range | is an intermediate in synthesizing 1- β-D-Ribofuranosyl-3-aminocarbonyl Guandinine (R415500), which is an impurity of 5-Azacytidine (A796000). 5-Azacytidine is a potent growth inhibitor and cytotoxic agent. 5-Azacytidine acts as a demethylating agent by inhibiting DNA methyltransferase. Group: Biochemicals. Grades: Highly Purified. CAS No. 58975-55-6. Pack Sizes: 25g, 50g. Molecular Formula: C15H13N3O2S. US Biological Life Sciences. | Worldwide |
1-(5-O-Acetyl- β-D-ribofuranosyl)-4-amino-1,3,5-triazin-2(1H)-one Quick inquiry Where to buy Suppliers range | 1-(5-O-Acetyl- β-D-ribofuranosyl)-4-amino-1,3,5-triazin-2(1H)-one is an impurity of 5-Azacytidine (A796000), a potent growth inhibitor and cytotoxic agent. It acts as a demethylating agent by inhibiting DNA methyltransferase. Group: Biochemicals. Grades: Highly Purified. CAS No. 1174733-90-4. Pack Sizes: 10mg, 100mg. Molecular Formula: C10H14N4O6. US Biological Life Sciences. | Worldwide |
1- β-D-Ribofuranosyl-3-aminocarbonyl Guandinine Quick inquiry Where to buy Suppliers range | 1- β-D-Ribofuranosyl-3-aminocarbonyl Guandinine is an impurity of 5-Azacytidine (A796000) which is a potent growth inhibitor and cytotoxic agent. 5-Azacytidine acts as a demethylating agent by inhibiting DNA methyltransferase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C7H14N4O5, Molecular Weight: 234.21. US Biological Life Sciences. | Worldwide |
1- β-D-Ribofuranosyl-3-iminohydroxymethyl Guandinine Quick inquiry Where to buy Suppliers range | 1- β-D-Ribofuranosyl-3-iminohydroxymethyl Guandinine is an impurity of 5-Azacytidine (A796000) which is a potent growth inhibitor and cytotoxic agent. 5-Azacytidine acts as a demethylating agent by inhibiting DNA methyltransferase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C7H14N4O5, Molecular Weight: 234.21. US Biological Life Sciences. | Worldwide |
1-Chloro-3-iodopropane Quick inquiry Where to buy Suppliers range | 1-Chloro-3-iodopropane is used as reagent in the synthesis of several organic compounds including that of (-)-Terengganensine A which is a complex heptacyclic monoterpene indole alkaloid. Also used in the synthesis of A-366 which is a potent inhibitor of histone methyltransferase G9a. Group: Biochemicals. Grades: Highly Purified. CAS No. 6940-76-7. Pack Sizes: 1g, 5g. Molecular Formula: C3H6ClI. US Biological Life Sciences. | Worldwide |
1-Methyl-4-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridin-2-yl]piperazine Quick inquiry Where to buy Suppliers range | 1-Methyl-4-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridin-2-yl]piperazine is used to prepare yrazolopyridine and indazoles as histone lysine methyltransferase EZH2 inhibitors. It is also used to synthesize tetrahydropyrido pyrazines as anaplastic lymphoma kinase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 918524-63-7. Pack Sizes: 50mg, 100mg. Molecular Formula: C16H26BN3O2, Molecular Weight: 303.209999999999. US Biological Life Sciences. | Worldwide |
1-Methyl Adenosine-d3 Quick inquiry Where to buy Suppliers range | 1-Methyl Adenosine-d3 is the isotope labelled analog of 1-Methyl Adenosine (M285065); a modified adenosine molecule created through the processing of tRNA by methyltransferases. The presence seen to be elevated in the urinary excretion of cancer patients. Thus it may be an early diagnosis biomarker. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C11H12D3N5O4, Molecular Weight: 284.29. US Biological Life Sciences. | Worldwide |
2,3,4,5-Tetrahydro-1H-2-benzazepine Quick inquiry Where to buy Suppliers range | 2,3,4,5-Tetrahydro-1H-2-benzazepine is used in the Comparative molecular field analysis (CoMFA) of phenylethanolamine N-methyltransferase (PNMT) and the α2-adrenoceptor, as a guide to develop selective inhibitors of phenylethanolamine N-methyltransferase (PNMT) vs. the α2-adrenoceptor. Group: Biochemicals. Grades: Highly Purified. CAS No. 7216-22-0. Pack Sizes: 100mg, 250mg. Molecular Formula: C10H13N, Molecular Weight: 147.22. US Biological Life Sciences. | Worldwide |
2',3',5'-triacetyl-5-azacytidine Quick inquiry Where to buy Suppliers range | 5-Azacytidine is an inhibitor of DNA methyltransferase, potentially serving to reverse epigenetic changes. 2',3',5'-triacetyl-5-Azacytidine is a prodrug form of 5-azacytidine. Synonyms: 5-Azacytidine 2',3',5'-O-triacetate; 2',3',5'-Triacetate-4-amino-1-β-D-ribofuranosyl-s-triazin-2(1H)-one; 2',3',5'-Tri-O-acetyl-5-Azacitidine; NSC 291930; 4-Amino-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one. Grades: ≥98% by HPLC. CAS No. 10302-78-0. Molecular formula: C14H18N4O8. Mole weight: 370.31. | |
2',3',5'-Tribenzoate D-Ribofuranosyl-urea Quick inquiry Where to buy Suppliers range | 2',3',5'-Tribenzoate D-Ribofuranosyl-urea is a by-product compound produced during the syntheses of 1- β-D-Ribofuranosyl-3-aminocarbonyl Guandinine (R415500), which is an impurity of 5-Azacytidine (A796000). 5-Azacytidine is a potent growth inhibitor and cytotoxic agent. 5-Azacytidine acts as a demethylating agent by inhibiting DNA methyltransferase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 50mg, 100mg. Molecular Formula: C27H24N2O8. US Biological Life Sciences. | Worldwide |
2',3',5'-Tribenzoate D-Ribofuranosyl-urea Quick inquiry Where to buy Suppliers range | 2',3',5'-Tribenzoate D-Ribofuranosyl-urea, a by-product compound produced during the syntheses of 1-β-D-Ribofuranosyl-3-aminocarbonyl Guandinine, that is an impurity of 5-Azacytidine. 5-Azacytidine is a potent growth inhibitor and cytotoxic agent. 5-Azacytidine acts as a demethylating agent by inhibiting DNA methyltransferase. Synonyms: D-Ribofuranosyl-urea Tribenzoate; (2,3,5-Tri-O-benzoyl-D-ribofuranosyl)-urea. Molecular formula: C27H24N2O8. Mole weight: 504.49. | |
2',3',5'-Tri-O-(4-chlorobenzoyl) 5-Azacytidine Quick inquiry Where to buy Suppliers range | The biomedical compound, 2',3',5'-Tri-O-(4-chlorobenzoyl) 5-Azacytidine, has emerged as a revolutionary treatment option for diverse ailments, including cancer. By effectively curtailing DNA methyltransferase activity, this potent pharmaceutical entity induces DNA demethylation, thereby revitalizing tumor suppressor genes that were once dormant. Prominently employed in the realm of epigenetic therapy, it exhibits remarkable efficacy in combatting hematological malignancies, unraveling new prospects in the medical landscape. Molecular formula: C29H21Cl3N4O8. Mole weight: 659.86. | |
2',3',5'-Tri-O-(p-chlorobenzoyl)-5-azacytidine Quick inquiry Where to buy Suppliers range | 2',3',5'-Tri-O-(p-chlorobenzoyl)-5-azacytidine, an immensely powerful and discriminative antineoplastic compound, finds its application in the therapeutic regimen of diverse malignancies such as leukemia and myelodysplastic syndromes. By impeding DNA methyltransferase, this agent instigates DNA hypomethylation and reawakens dormant tumor suppressor genes. Synonyms: 2',3',5'-Tri-O-(p-chlorobenzoyl)-5-aza-D-cytidine. CAS No. 158778-00-8. Molecular formula: C29H21Cl3N4O8. Mole weight: 659.86. | |
2-Aminoindan Quick inquiry Where to buy Suppliers range | 2-Aminoindan is an analgesic with sympathomimetic activity. 2-Aminoindan is an inhibitor norepinephrine methyltransferase. Group: Biochemicals. Alternative Names: 2-Indanamine; (2,3-Dihydro-1H-inden-2-yl)amine; 2,3-Dihydro-1H-inden-2-amine; 2-Amino-2,3-dihydro-1H-indene; 2-Aminoindane; 2-Indanylamine; Su 8629. Grades: Highly Purified. CAS No. 2975-41-9. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
2-(Benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic Acid Quick inquiry Where to buy Suppliers range | 2-(Benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic Acid is a small molecule that has been reported as a novel histone methyltransferase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 1374601-41-8. Pack Sizes: 1mg, 5mg. Molecular Formula: C24H21N3O3, Molecular Weight: 399.44. US Biological Life Sciences. | Worldwide |
2-[ (Benzoylimino) (methylthio) methyl]hydrazide Benzoic Acid Quick inquiry Where to buy Suppliers range | 2-[ (Benzoylimino) (methylthio) methyl]hydrazide Benzoic Acid is an intermediate in synthesizing 1- β-D-Ribofuranosyl-3-aminocarbonyl Guandinine (R415500), which is an impurity of 5-Azacytidine (A796000). 5-Azacytidine is a potent growth inhibitor and cytotoxic agent. 5-Azacytidine acts as a demethylating agent by inhibiting DNA methyltransferase. Group: Biochemicals. Grades: Highly Purified. CAS No. 74074-45-6. Pack Sizes: 25g, 50g. Molecular Formula: C16H15N3O2S. US Biological Life Sciences. | Worldwide |
2-Bromo-4-methoxy-1- (trifluoromethyl) benzene Quick inquiry Where to buy Suppliers range | 2-Bromo-4-methoxy-1- (trifluoromethyl) benzene is used as a reactant in the synthetic preparation of amino(aryloxy)propanol derivatives as coactivator-associated arginine methyltransferase (CARM1) inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 944901-07-9. Pack Sizes: 250mg, 500mg. Molecular Formula: C8H6BrF3O, Molecular Weight: 255.03. US Biological Life Sciences. | Worldwide |
2'-Chloro-N6-(4-methoxy)benzyladenosine Quick inquiry Where to buy Suppliers range | 2'-Chloro-N6-(4-methoxy)benzyladenosine, a compound with diverse pharmacological effects, is utilized in biomedicine as an effective inhibitor of RNA methyltransferase and adenosine kinase, pivotal enzymes associated with a multitude of debilitating diseases including cancer, neurological disorders, and viral infections. Additionally, this chemical species demonstrates strong anti-inflammatory properties, making it a promising therapeutic target for treating a variety of inflammation-related maladies. Synonyms: (2R,3R,4S,5R)-2-[2-chloro-6-[(4-methoxyphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol; 2-Chloro-N-(4-methoxybenzyl)adenosine; Adenosine, 2-chloro-N-[(4-methoxyphenyl)methyl]-. Grades: ≥95%. CAS No. 722504-77-0. Molecular formula: C18H20ClN5O5. Mole weight: 421.83. | |
2-Deoxy-D-erythro-pentofuranose 5-(4-Methylbenzoate) Quick inquiry Where to buy Suppliers range | 2-Deoxy-D-erythro-pentofuranose 5-(4-methylbenzoate) is an impurity of Decitabine (α-isomer), a DNA hypomethylating agent that is used to treat various forms of cancer, such as myelogeneous leukemia and metastatic lung cancerBy inhibiting DNA methyltransferase, Decitabine silences the tumor suppressor genes and, consequently, normalizing gene expression in cancerous cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg, 1g. Molecular Formula: C13H16O5, Molecular Weight: 252.26. US Biological Life Sciences. | Worldwide |
2-Deoxy-D-erythro-pentofuranose 5-(4-Methylbenzoate) Quick inquiry Where to buy Suppliers range | 2-Deoxy-D-erythro-pentofuranose 5-(4-methylbenzoate) is an impurity of Decitabine (α-isomer), a DNA hypomethylating agent that is used to treat various forms of cancer e.g., myelogeneous leukemia and metastatic lung cancer by inhibiting DNA methyltransferase, Decitabine silences the tumour suppressor genes and, consequently, "normalizing" gene expression in cancerous cells. Molecular formula: C13H16O5. Mole weight: 252.26. | |
2-MeS-Ado Quick inquiry Where to buy Suppliers range | 2-MeS-Ado is an inhibitor of human betaine-homocysteine methyltransferase. Synonyms: 2- Methylthioadenosine. Grades: ≥ 98% by HPLC. CAS No. 4106-39-9. Molecular formula: C11H16N6O4S. Mole weight: 313.4. | |
2-Methoxy-4-(2-nitroethyl)phenol-d3 Quick inquiry Where to buy Suppliers range | 2-Methoxy-4-(2-nitroethyl)phenol-d3 is a major metabolite of Dopamine (D533780); product of catechol O-methyltransferase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 25mg. Molecular Formula: C9H8D3NO4, Molecular Weight: 200.21. US Biological Life Sciences. | Worldwide |
2'-O-Methyl-5-methyluridine 5'-triphosphate Quick inquiry Where to buy Suppliers range | 2'-O-Methyl-5-methyluridine 5'-triphosphate is a pivotal element for studying the captivating realm of RNA modifications. Profoundly influencing diverse cellular processes, this exquisite modified nucleotide assuming a paramount role in unraveling the enigmatic function of methylated RNA. As a versatile substrate for RNA-modifying enzymes, it unleashes unprecedented opportunities to scrutinize mesmeric methyltransferase activities and decode the multifaceted impact of this modification on the intricate structure and myriad functions of RNA. Synonyms: (((2R,3R,4R,5R)-3-Hydroxy-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl)triphosphoric acid. CAS No. 444789-41-7. Molecular formula: C11H19N2O15P3. Mole weight: 512.19. | |
3',8-Dihydroxy-4',6,7-trimethoxyisoflavone Quick inquiry Where to buy Suppliers range | It is produced by the strain of Streptomyces sp. It is a catechole-O-methyltransferase inhibitor (IC50 is 0.2 g/mL). Synonyms: 6,7-Dimethoxy-8-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran; 4H-1-Benzopyran, 6,7-dimethoxy-8-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-. CAS No. 57800-11-0. Molecular formula: C18H16O7. Mole weight: 344.32. | |
3-(Aminomethyl)-4,6-dimethylpyridin-2(1H)-one Quick inquiry Where to buy Suppliers range | 3-(Aminomethyl)-4,6-dimethylpyridin-2(1H)-one is a reactant in the preparation of pyrazolopyridine and indazoles as histone lysine methyltransferase EZH2 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 771579-27-2. Pack Sizes: 50mg, 250mg. Molecular Formula: C8H12N2O, Molecular Weight: 152.19. US Biological Life Sciences. | Worldwide |
3'-b-C-Methyl-N6-methyladenosine Quick inquiry Where to buy Suppliers range | 3'-b-C-Methyl-N6-methyladenosine is a remarkable compound, holding immense potential in research of diverse ailments such as cancer and neurodegenerative disorders. Impressively, it performs as an influential suppressor of RNA methyltransferases, skillfully governing RNA metabolism and controlling gene expression. Synonyms: 3'-beta-C-Methyl-N6-methyladenosine; Adenosine, N-methyl-3'-C-methyl-; N-Methyl-3'-C-methyladenosine. Grades: ≥95%. CAS No. 565450-84-2. Molecular formula: C12H17N5O4. Mole weight: 295.29. | |
3-Bromo-4- (methoxymethoxy) benzaldehyde Quick inquiry Where to buy Suppliers range | 3-Bromo-4- (methoxymethoxy) benzaldehyde is an intermediate in synthesizing CARM1-IN-1 Hydrochloride (C183610), a mixed Histone/Protein Methyltransferase, Acetyltransferase, and Class III Deacetylase (Sirtuin) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 162269-90-1. Pack Sizes: 50mg, 100mg. Molecular Formula: C9H9BrO3. US Biological Life Sciences. | Worldwide |
3-Chloro-2-(2-methoxyphenyl)-6-(pyperidin-4-yl)indole Quick inquiry Where to buy Suppliers range | 3-Chloro-2-(2-methoxyphenyl)-6-(pyperidin-4-yl)indole is a metabolite of 3-Chloro-2- (2-methoxyphenyl) -6-[N- (2-methylaminoethyl) pyperidin-4-yl]indole (C368835) which is used in the preparation of heterocyclic inhibitors of protein argenine methyltransferases; compounds used for treating hyperproliferative, inflammatory, infectious, and immunoregulatory disorders and diseases. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C20H21ClN2O, Molecular Weight: 340.85. US Biological Life Sciences. | Worldwide |
3-Deazaneplanocin A Quick inquiry Where to buy Suppliers range | 3-Deazaneplanocin A is an inhibitor of S-adenosylmethionine-dependent methyltransferase. In combination with sodium butyrate, 3-Deazaneplanocin A can induce epigenetically reprogramming of human embryonic stem cells (hESC). Synonyms: DZNep; (1S,2R,5R)-5-(4-aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol. Grades: >98%. CAS No. 102052-95-9. Molecular formula: C12H14N4O3. Mole weight: 262.26. | |
3-Deazaneplanocin A (DZNep, NSC 617989) Quick inquiry Where to buy Suppliers range | A lysine methyltransferase EZH2 (KMT63) inhibitor. DZNep is a selective inhibitor of trimethylation of lysine 27 on histone H3 (H3K27me3) and lysine 20 on histone H4 (H4K20me3). DZNep treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis. Group: Biochemicals. Alternative Names: 5R-(4-amino-1H-imidazo[4, 5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1S, 2R-diol). Grades: Highly Purified. CAS No. 102052-95-9. Pack Sizes: 250ug, 1mg. US Biological Life Sciences. | Worldwide |
3'-Deoxy-N1-Methylinosine Quick inquiry Where to buy Suppliers range | 3'-Deoxy-N1-Methylinosine is a renowned biomedicine, standing as a preeminent remedy for DNA methylation-related afflictions. Fostering its efficacy, this remarkable compound manifesting itself as an influential suppressor of DNA methyltransferase enzymes, thereby unveiling its therapeutic prowess in combatting neoplastic maladies and hereditary irregularities. Grades: ≥95%. Molecular formula: C11H14N4O4. Mole weight: 266.25. | |
3-Mercaptotyramine, Hydrochloride Quick inquiry Where to buy Suppliers range | 3-Mercaptotyramine, the mercapto analog of dopamine, irreversibly inhibits the enzyme, catechol-O-methyltransferase, presumably by the formation of an SS bridge to a reactive mercapto group in the reactive site. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
3-O-Methyl-L-DOPA-d3 Methyl Ester Quick inquiry Where to buy Suppliers range | Protected labeled 3-O-Methyl-L-DOPA. 3-O-Methyl-L-DOPA is the major metabolite of L-DOPA via catechol O-methyltransferase (COMT). 3-Methoxy-L-tyrosine is neither a substrate for nor an inhibitor of L-amino acid decarboxylase activity. Inhibition of COMT enhances the anti-Parkinson activity of L-DOPA. Group: Biochemicals. Alternative Names: 3-Methoxy-d3-L-tyrosine Methyl Ester. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
3-O-Methyl-L-DOPA-d3 Monohydrate Quick inquiry Where to buy Suppliers range | Labeled 3-O-Methyl-L-DOPA. 3-O-Methyl-L-DOPA is the major metabolite of L-DOPA via catechol O-methyltransferase (COMT). 3-Methoxy-L-tyrosine is neither a substrate for nor an inhibitor of L-amino acid decarboxylase activity. Inhibition of COMT enhances the anti-Parkinson activity of L-DOPA. Group: Biochemicals. Alternative Names: 3-(Methoxy-d3)-L-tyrosine Monohydrate; 3-(Methoxy-d3)-4-hydroxyphenylalanine Monohydrate; 3-(Methoxy-d3)-DOPA Monohydrate; 3-(Methoxy-d3)-L-tyrosine Monohydrate; 3-O-(Methyl-d3)dopa Monohydrate; L-3-(Methoxy-d3)-4-hydroxy-phenylalanine Monohydrate; L-3-O-(Methyl-d3)-DOPA Monohydrate; L-4-Hydroxy-3-(methoxy-d3)phenylalanine Monohydrate. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
3-O-Methyl-L-DOPA Methyl Ester Quick inquiry Where to buy Suppliers range | Protected 3-O-Methyl-L-DOPA. 3-O-Methyl-L-DOPA is the major metabolite of L-DOPA via catechol O-methyltransferase (COMT). 3-Methoxy-L-tyrosine is neither a substrate for nor an inhibitor of L-amino acid decarboxylase activity. Inhibition of COMT enhances the anti-Parkinson activity of L-DOPA. Group: Biochemicals. Alternative Names: 3-Methoxy-L-tyrosine Methyl Ester. Grades: Highly Purified. CAS No. 78148-37-5. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
3-O-Methyl-L-DOPA Monohydrate Quick inquiry Where to buy Suppliers range | 3-O-Methyl-L-DOPA is the major metabolite of L-DOPA via catechol O-methyltransferase (COMT). 3-Methoxy-L-tyrosine is neither a substrate for nor an inhibitor of L-amino acid decarboxylase activity. Inhibition of COMT enhances the anti-Parkinson activity of L-DOPA. Group: Biochemicals. Alternative Names: 3-Methoxy-L-tyrosine Monohydrate; 3-Methoxy-4-hydroxyphenylalanine Monohydrate; 3-Methoxy-DOPA Monohydrate; 3-Methoxy-L-tyrosine Monohydrate; 3-O-Methyldopa Monohydrate; L-3-Methoxy-4-hydroxyphenylalanine Monohydrate; L-3-O-Methyl-DOPA Monohydrate; L-4-Hydroxy-3-methoxyphenylalanine Monohydrate. Grades: Highly Purified. CAS No. 200630-46-2. Pack Sizes: 10mg, 25mg, 50mg. US Biological Life Sciences. | Worldwide |
3-O-Toluoyl decitabine Quick inquiry Where to buy Suppliers range | 3-O-Toluoyl decitabine is an extraordinary compound widely employed in the research of diverse cancers, particularly the acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), functioning as a potent DNA methyltransferase inhibitor. Its unparalleled ability to efficiently demethylate and reactivate the dormant tumor-suppressor genes accentuates its immense potential for curbing is and even regressing, the menacing onslaught of cancer. Synonyms: 4-Amino-1-[2-deoxy-3-O-(4-methylbenzoyl)-b-D-erythro-pentofuranosyl]-1,3,5-triazin-2(1H)-one. CAS No. 183016-21-9. Molecular formula: C16H18N4O5. Mole weight: 346.34. | |
5,6-Dihydro-5-azacytidine acetate Quick inquiry Where to buy Suppliers range | 5,6-Dihydro-5-azacytidine acetate, an impactful biomedicine, emerges as a therapeutic wonder for select cancer types including leukemia and diverse hematological malignancies. By acting as an inhibitor of DNA methyltransferase, it adeptly averts DNA methylation, thereby engendering a revitalization of tumor suppressor genes. Its profound involvement in the realm of epigenetic therapy conveys immense potential for augmenting patient prognoses within the realm of oncology. Grades: ≥ 95% (HPLC). Molecular formula: C10H17N4O7. Mole weight: 305.26. | |
5-(Acetylamino)-2-hydroxybenzoic acid Quick inquiry Where to buy Suppliers range | N-Acetyl Mesalazine is a metabolite of Mesalazine. It is a Salicylic Acid derivative. It is an inhibitor of recombinant human thiopurine methyltransferase (hTPMT). Synonyms: 5-acetamido-2-hydroxybenzoic acid. Grades: > 95 %. CAS No. 51-59-2. Molecular formula: C9H9NO4. Mole weight: 195.17. | |
5-Aza-3',5'-di-O-acetyl-2'-deoxycytidine Quick inquiry Where to buy Suppliers range | 5-Aza-3',5'-di-O-acetyl-2'-deoxycytidine is an influential pharmaceutical compound, showcasing remarkable antitumor attributes. Renowned for its versatile applications, it finds extensive research in combatting diverse malignancies such as leukemia, lung cancer and colon cancer. Functioning as a DNA methyltransferase inhibitor, its mechanism revolves around counteracting epigenetic alterations, thus facilitating the reinstatement of regular cellular operations. Molecular formula: C12H16N4O6. Mole weight: 312.28. | |
5-Azacytidine Quick inquiry Where to buy Suppliers range | A potent growth inhibitor and cytotoxic agent. It acts as a demethylating agent by inhibiting DNA methyltransferase. Group: Biochemicals. Alternative Names: Azacitidine; 4-Amino-1- β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one; 5-AC; 5-AZC; 5-AZCR; 5-AzaC; Antibiotic U 18496; Azacytidine; Ladakamycin; Ledakamycin; Mylosar; NSC 102816; NSC 103-627; U 18496; Vidaza; WR 183027. Grades: Highly Purified. CAS No. 320-67-2. Pack Sizes: 1g, 5g, 10g. Molecular Formula: C8H12N4O5, Molecular Weight: 244.2. US Biological Life Sciences. | Worldwide |
5-Azacytidine-15N4 Quick inquiry Where to buy Suppliers range | Labeled Azacytidine, a potent growth inhibitor and cytotoxic agent. It acts as a demethylating agent by inhibiting DNA methyltransferase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
5-Aza-N6-benzoyl-5'-O-DMT-2'-deoxycytidine 3'-CE phosphoramidite Quick inquiry Where to buy Suppliers range | 5-Aza-N6-benzoyl-5'-O-DMT-2'-deoxycytidine 3'-CE phosphoramidite, a bio-molecular tool, facilitates the integration of 5-aza-2'-deoxycytidine into oligonucleotides. This inhibits DNA methyltransferase and affords therapeutic benefits such as anti-cancer activity. The phosphoramidite reagent is a research asset that enables differential and accurate DNA sequence modification for targeted epigenetic investigation. It thus contributes to newer approaches in therapeutic interventions. Synonyms: (2R, 3S, 5R)-2- ( (Bis (4-methoxyphenyl) (phenyl)methoxy)methyl)-5- (2-oxo-4- (2-phenoxyacetamido)-1, 3, 5-triazin-1 (2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 929904-98-3. CAS No. 929904-98-3. Molecular formula: C46H53N6O9P. Mole weight: 864.92. | |
5'-DMT-2'-deoxycytidine (N-Ac) Quick inquiry Where to buy Suppliers range | 5'-DMT-2'-deoxycytidine (N-Ac) is a pharmacological agent employed in the domain of biomedical research for the exploration of the epigenetic mechanisms responsible for gene expression modulation, with specific attention to the pathogenesis of cancer. Its chemical structure harbors a dimethylthiazolidine ring and an N-acetyl moiety at the 5' position, imparting functional properties closely related to its DNA methyltransferase inhibitory and DNA demethylation-promoting actions, largely responsible for the compound's anti-tumor activity. Grades: ≥ 98% by HPLC. Molecular formula: C32H33N3O7. Mole weight: 571.62. | |
5-Methyl-dCTP Quick inquiry Where to buy Suppliers range | 5-Methyl-dCTP, a paramount component within the biomedical industry, is deeply engrossed in DNA synthesis. During cell division and replication, it becomes embedded into DNA and is implemented by DNA methyltransferases to methylate CpG islands. Its potential for detection and quantification of DNA methylation in diverse diseases, such as cancer and neurodegenerative disorders, makes it a popular choice. Synonyms: 5-Methyl-2'-deoxycytidine-5'-Triphosphate; m5-dCTP; 5-m-dCTP; 5m-dCTP; 5-methyldeoxycytidine triphosphate. Grades: ≥ 95% by HPLC. CAS No. 22003-12-9. Molecular formula: C10H18N3O13P3 (free acid). Mole weight: 481.18 (free acid). | |
6-Mercaptopurine Monohydrate Quick inquiry Where to buy Suppliers range | 6-Mercaptopurine Monohydrate is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. Uses: An immunosuppressive drug used to treat leukemia. it is also used for pediatric non-hodgkin's lymphoma, polycythemia vera, and psoriatic arthritis. Synonyms: 6H-Purine-6-thione, 1,7-dihydro-, monohydrate; 6,7-dihydro-3H-purine-6-thione hydrate; 1,7-Dihydro-6H-purine-6-thione monohydrate. Grades: 98 %. CAS No. 6112-76-1. Molecular formula: C5H4N4S · H2O. Mole weight: 170.19. | |
7-Methylguanosine 5'-triphosphate sodium salt Quick inquiry Where to buy Suppliers range | 7-Methylguanosine 5'-triphosphate sodium salt, a highly indispensable reagent in the field of biomedicine, finds extensive utilization across diverse applications. Functioning as a potent guanosine triphosphate (GTP) analogue, it assumes a pivotal role in the processes of mRNA capping, RNA processing, and RNA splicing. Its auxiliary role involves facilitating the exploration of RNA-protein interactions while also serving as a substrate for RNA methyltransferases. Molecular formula: C11H18N5O14P3·xNa. Mole weight: 537.21 (free acid). | |
7'-OH-N-DMTr morpholino-5-methyluracil Quick inquiry Where to buy Suppliers range | 7'-OH-N-DMTr morpholino-5-methyluracil is a revolutionary and groundbreaking compound, intricately designed to study a myriad of ailments plaguing humanity. This unparalleled concoction emerges as an exquisite methyltransferase inhibitor, meticulously honing in on select enzymes participating in the delicate orchestration of DNA methylation. Synonyms: N-DMTr-morpholino-T. Grades: ≥95%. Molecular formula: C31H33N3O6. Mole weight: 543.61. | |
7-TFA-ap-7-Deaza-2'-dA Quick inquiry Where to buy Suppliers range | 7-TFA-ap-7-Deaza-2'-dA, a cutting-edge nucleotide analog in the field of biomedicine is emerging as a promising and potent inhibitory agent against DNA methyltransferases in epigenetic studies. Its medicinal potential is being widely explored as a possible panacea for mitigating methylation abnormalities underlying genetic disorders and cancers. Synonyms: 7-TFA-ap-7-Deaza-dA; N-[3-[4-Amino-7-(2-deoxy-beta-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-yl]-2-propynyl]-2,2,2-trifluoroacetamide; 7-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-{3-[(trifluoroacetyl)amino]-1-propyn-1-yl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine. Grades: ≥98% by HPLC. CAS No. 178420-75-2. Molecular formula: C16H16F3N5O4. Mole weight: 399.32. | |
8-Amino[1''-(N''-dansyl)-4''-aminobutyl]-5'-(1-aziridinyl)-5'-deoxy Adenosine Quick inquiry Where to buy Suppliers range | A fluorescent cofactor reagent for the sequence-specific labeling of DNA methyltransferase from Thermus aquaticus (M*Taql). It binds about 4-fold better than the natural cofactor AdoMet to M*Taql. In addition, the reagent can be used to sequence-specifically label plasmid DNA in a M*Taql-catalyzed reaction. Synonyms: 9-[(2xi)-5-(Aziridin-1-yl)-5-deoxy-beta-D-threo-pentofuranosyl]-N~8~-(4-{[5-(dimethylamino)naphthalene-1-sulfonyl]amino}butyl)-9H-purine-6,8-diamine; N-[4-[[6-amino-9-[(2R,4R,5R)-5-(aziridin-1-ylmethyl)-3,4-dihydroxyoxolan-2-yl]purin-8-yl]amino]butyl]-5-(dimethylamino)naphthalene-1-sulfonamide; 8-Amino[1"-(N"-dansyl)-4"-aminobutyl]-5'-(1-aziridinyl)-5'-deoxy Adenosine; DTXSID90675569; 8-Amino[1 inverted exclamation mark+/--(N inverted exclamation mark+/--dansyl)-4 inverted exclamation mark+/--aminobutyl]-5 inverted exclamation mark -(1-aziridinyl)-5 inverted exclamation mark -deoxy Adenosine. Grades: > 95%. CAS No. 256953-68-1. Molecular formula: C28H37N9O5S. Mole weight: 611.72. | |
8-PT-Ado Quick inquiry Where to buy Suppliers range | 8-PT-Ado, a nucleoside analog employed for biomedical research, holds promise as an antiviral and anticancer drug. Notably, potency against leukemia and herpes simplex virus has been found. Engaging apoptosis induction, DNA synthesis inhibition, and DNA methyltransferase interference, 8-PT-Ado has also been seen to suppress the NF-κB pathway. This pathway is critical for the progression of inflammation and cancer. Synonyms: 8- Phenylthioadenosine. Grades: ≥ 97 % by HPLC. Molecular formula: C16H17N6O4S. Mole weight: 376.4. |