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| Product | Description | |
|---|---|---|
| Microcystin-LA | Microcystin is a class of cyclic heptapeptide toxins produced by cyanobacteria. Microcystin-LA is an analog of the major microcystin-LR with the substitution of alanine in place of the arginine. It inhibits both PP1C and PP2A with IC50 value of 0.3 nM. Synonyms: Cyanoginosin-LA; Toxin BE4. Grades: ≥95%. CAS No. 96180-79-9. Molecular formula: C46H67N7O12. Mole weight: 910.06. |  |
| Microcystin-LR | Microcystin-LR is a selective inhibitor of protein phosphatase 2A (PP2A) (IC50= 0.04 nM) and will completely inhibit this enzyme without affecting PP1 when used at a concentration of 0.5 nM.2 The PP1 IC50 is about 1.7 nM. Microcystins are at least 10 times more potent as serine/threonine PP inhibitors than okadaic acid, another microalgal toxin also used for this purpose. Uses: Enzyme inhibitors. Synonyms: Microcystin LR; Microcystin; Microcystin-a; MicrocystinLR; Cyanoginosin-LR; Toxin T 17; cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-(3S)-3-methyl-D-β-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl]; 5-L-Arginine-microcystin LA; cyclo(Ala-Leu-MAsp-Arg-Adda-isoGlu-Mdha). Grades: >95%. CAS No. 101043-37-2. Molecular formula: C49H74N10O12. Mole weight: 995.17. | |
| Microcystin-RR | It is produced by the strain of Microcystis aeruginosa. Microcystin-RR inhibits PP1C, PP1γ, and PP2A with Ki values of 0.15, 0.24, and 0.018 nM, respectively. Synonyms: Cyanoginosin RR; Microcystin-RR; Cyanoginosin-RR; (5R,8S,11R,12S,15S,18S,19S,22R)-8,15-bis[3-(diaminomethylideneamino)propyl]-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dienyl]-1,5,12,19-tetramethyl-2-methylidene-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21-heptazacyclopentacosane-11,22-dicarboxylic acid; Cyanoginosin LA, 3-arginyl-5-arginine-; MCYST-RR; MC-RR; Cyanoginosin LA, 3-L-arginyl-5-L-arginine; Cyanoginosin LA, 3-L-arginine-5-L-arginine-; MCRR; Microcystin-RR, Microcystis aeruginosa; Microcystin-RR solution; Microcystin RR from algae. Grades: ≥95%. CAS No. 111755-37-4. Molecular formula: C49H75N13O12. Mole weight: 1038.21. | |
| Microcystin WR | It is produced by the strain of Microcystis aeruginosa. Synonyms: 3-L-Tryptophan-5-L-arginine cyanoginosin La; (5R,8S,11R,12S,15S,18S,19S,22R)-15-(3-Carbamimidamidopropyl)-8-(1H-indol-3-ylmethyl)-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenyl-1,3-heptadien-1-yl]-1,5,12,19-tetramethyl-2-methylene-3,6,9,13,16 ,20,25-heptaoxo-1,4,7,10,14,17,21-heptaazacyclopentacosane-11,22-dicarboxylic acid. Grades: ≥98%. CAS No. 138234-58-9. Molecular formula: C54H73N11O12. Mole weight: 1068.24. | |
| [D-Asp3] Microcystin LR | Microcystin LR is a cyclic heptaceptide originally produced by the cyanobacteria microcystin aeruginosa. Microcystin LR has cytotoxic, pro-oxidative and carcinogenic properties. Synonyms: Asp3-Microcystin LR; Microcystin A; Microcystin-[D-Asp3]-LR; 3-Desmethylmicrocystin LR; Toxin II (Microcystis aeruginosa); Toxin T 16 (Microcystis aeruginosa); 4-D-β-Aspartic acid-5-L-argininemicrocystin LA; cyclo-Ala-Leu-isoAsp-Arg-Adda-isoGlu-N-Mdha; Cyclo[2,?3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-D-β-aspartyl-L-arginyl-(2S,?3S,?4E,?6E,?8S,?9S)?-3-amino-9-methoxy-2,?6,?8-trimethyl-10-phenyl-4,?6-decadienoyl-D-γ-glutamyl]; N(1)Arg-Unk-D-gGlu-N(Me)Dha-D-Ala-Leu-D-Asp(1)-OH. Grades: ≥98%. CAS No. 120011-66-7. Molecular formula: C48H72N10O12. Mole weight: 981.15. | |
| Native Bovine Protamine Kinase, Cytosolic | Cytosolic protamine kinase is involved in the regulation of protein synthesis and is indirectly associated with numerous cellular processes. Cytosolic protamine kinase is a distinct insulin-stimulated kinase involved in the phosphorylation of eukaryotic Initiation Factor 4E (eIF4E) which is key to initiating translation by mRNA. This protein appears to be inactivated by protein phosphatase 2A family members and may also be inhibited by microcystin, okadeic acid, and ATP. The phosphorylation process is reversible and MBPK1 and MBPK2 (Myelin Basic Protein Kinase 1 and 2) may reactivate cytosolic protamine kinase. Applications: Cytosolic protamine kinase (cpk) is isolated from bovine kidney and has a molecular mass of approximately 45 kda. it phosphorylates the eukaryotic initiation factor 4e (eif4e), which initiates translation by mrna. it is used to study protein synthesis and various cellular processes. Group: Enzymes. Synonyms: Protamine Kinase, Cytosolic; Cytosolic protamine kinase; CPK; Cpk. Purity: >90% (SDS-PAGE). CPK. Activity: > 15,000 units/mg protein. Form: buffered aqueous glycerol solution. Source: Bovine kidney. Species: Bovine. Protamine Kinase, Cytosolic; Cytosolic protamine kinase; CPK; Cpk. Cat No: NATE-0155. |  |
| Native Rabbit Protein Phosphatase 1C | Protein Phosphatase 1 is a growth factor stimulated, divalent cation-independent serine/threonine protein phosphatase involved in regulating numerous cellular processes such as glycogen metabolism, mitosis, and meiosis. Protein phosphatase 1c (pp1c) is expressed in the dendrites of retinal bipolar cells where it was found to bind to group i metabotropic glutamate receptors indicating a function for pp1c in glutamatergic signal transduction. >90% (sds-page), buffered aqueous glycerol solution. Applications: Protein phosphatase-1c has been used in a study to investigate why two metabolites of microcystin-lr glutathione conjugate and microcystin-cysteine conjugate, as well as microcystin-rr are less toxic than microcystin-lr. Group: Enzymes. Synonyms: Protein Phosphatase 1C; PP1C. Purity: >90% (SDS-PAGE). Protein Phosphatase. Activity: > 1500 units/mg protein. Stability: -70°C. Form: buffered aqueous glycerol solution. Source: Rabbit muscle. Species: Rabbit. Protein Phosphatase 1C; PP1C. Cat No: NATE-0615. | |
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