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| Product | Description | |
|---|---|---|
| Microcystin-LR | Microcystin-LR is a selective inhibitor of protein phosphatase 2A (PP2A) (IC50= 0.04 nM) and will completely inhibit this enzyme without affecting PP1 when used at a concentration of 0.5 nM.2 The PP1 IC50 is about 1.7 nM. Microcystins are at least 10 times more potent as serine/threonine PP inhibitors than okadaic acid, another microalgal toxin also used for this purpose. Uses: Enzyme inhibitors. Synonyms: Microcystin LR; Microcystin; Microcystin-a; MicrocystinLR; Cyanoginosin-LR; Toxin T 17; cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-(3S)-3-methyl-D-β-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl]; 5-L-Arginine-microcystin LA; cyclo(Ala-Leu-MAsp-Arg-Adda-isoGlu-Mdha). Grades: >95%. CAS No. 101043-37-2. Molecular formula: C49H74N10O12. Mole weight: 995.17. |  |
| Microcystin-LA | Microcystin is a class of cyclic heptapeptide toxins produced by cyanobacteria. Microcystin-LA is an analog of the major microcystin-LR with the substitution of alanine in place of the arginine. It inhibits both PP1C and PP2A with IC50 value of 0.3 nM. Synonyms: Cyanoginosin-LA; Toxin BE4. Grades: ≥95%. CAS No. 96180-79-9. Molecular formula: C46H67N7O12. Mole weight: 910.06. | |
| Native Rabbit Protein Phosphatase 1C | Protein Phosphatase 1 is a growth factor stimulated, divalent cation-independent serine/threonine protein phosphatase involved in regulating numerous cellular processes such as glycogen metabolism, mitosis, and meiosis. Protein phosphatase 1c (pp1c) is expressed in the dendrites of retinal bipolar cells where it was found to bind to group i metabotropic glutamate receptors indicating a function for pp1c in glutamatergic signal transduction. >90% (sds-page), buffered aqueous glycerol solution. Applications: Protein phosphatase-1c has been used in a study to investigate why two metabolites of microcystin-lr glutathione conjugate and microcystin-cysteine conjugate, as well as microcystin-rr are less toxic than microcystin-lr. Group: Enzymes. Synonyms: Protein Phosphatase 1C; PP1C. Purity: >90% (SDS-PAGE). Protein Phosphatase. Activity: > 1500 units/mg protein. Stability: -70°C. Form: buffered aqueous glycerol solution. Source: Rabbit muscle. Species: Rabbit. Protein Phosphatase 1C; PP1C. Cat No: NATE-0615. |  |
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