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| Product | Description | |
|---|---|---|
| Flavoglaucin | Flavoglaucin is a natural compound isolated from marine fungus Eurotium sp. SF-5989. Flavoglaucin exhibits significant inhibitory effect on PTP1B with IC50 value of 13.4 micrometer. Flavoglaucin shows good binding affinity for human opioid or cannabinoid receptors. Flavoglaucin has anti-inflammatory effect, which inhibits inflammatory mediators via the induction of heme oxygenase-1 in lipopolysaccharide-stimulated RAW264.7 macrophages. Flavoglaucin exhibits significant radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with the IC50 value of 11.3 microM. Synonyms: 6-Heptyl-3-(3-methyl-2-butenyl)gentisaldehyde; Benzaldehyde, 2-heptyl-3,6-dihydroxy-5-(3-methyl-2-butenyl)-. Grades: 98.0%. CAS No. 523-73-9. Molecular formula: C19H28O3. Mole weight: 304.42. |  |
| Sodium Stearate | Vegetable-based aqueous thickener and gelling agent, emulsifying agent (o/w), and cleansing agent. Consists primarily of the sodium salts of saturated C16 & C18 fatty acids. Particle size (thru 100 mesh) approx. 0.4 micrometers. Uses: Stick cosmetics (e.g. deodorants), color cosmetics, soaps, creams, lotions, sunscreens, after sun care products. Additional or Alternative Names: Stearic acid, sodium salt. Product Category: Anionic SurfactantsSoaps of Fatty Acids. Appearance: Off-white powder. CAS No. 822-16-2. Molecular formula: C18H35NaO2. Mole weight: 306.46. Purity: 98%+. IUPACName: Sodium;octadecanoate. Canonical SMILES: CCCCCCCCCCCCCCCCCC(=O)[O-].[Na+]. Density: 1.103 g/cm³. Product ID: ACM822162. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Suspended monolayer graphene on TEM grid substrate (Quantifoil gold) | Transfer Method: Clean transfer method Size: 2 mm (TEM grid diameter) Appearance (Color): Transparent Coverage: >95% Number of graphene layers: single layer Thickness (theoretical): 0.345 nm FET Electron Mobility on Al2O3: 2; 000 cm2 /Vs FET Electron Mobility on SiO2/Si (expected): 4; 000 cm2 /Vs Sheet Resistance: 170 Ohms/sq. Grain size: up to 10 micrometer. Uses: Graphene film on tem grid is useful for high resolution tem imaging of nanoscale materials because it preserves the same focal plane over the whole grid mesh. Group: Carbon nano materials. |  |
| Bemcentinib | Bemcentinib is a selective small molecule inhibitor of Axl kinase, which showed activity to blocks tumor spread and prolongs survival in models of metastatic breast cancer. The receptor tyrosine kinase Axl may play an important role in cancer progression, invasion, metastasis, drug resistance, and patient mortality. R428 inhibits Axl with low nanomolar activity and blocked Axl-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production. Pharmacologic investigations revealed favorable exposure after oral administration such that R428-treated tumors displayed a dose-dependent reduction in expression of the cytokine granulocyte macrophage colony-stimulating factor and the epithelial-mesenchymal transition transcriptional regulator Snail. In support of an earlier study, R428 inhibited angiogenesis in corneal micropocket and tumor models. R428 administration reduced metastatic burden and extended survival in MDA-MB-231 intracardiac and 4T1 orthotopic (median survival, >80 days compared with 52 days; P < 0.05) mouse models of breast cancer metastasis. Additionally, R428 synergized with cisplatin to enhance suppression of liver micrometastasis. Our results show that Axl signaling regulates breast cancer metastasis at multiple levels in tumor cells and tumor stromal cells and that selective Axl blockade confers therapeutic value in prolonging survival of animals bearing metastatic tumors. Synonyms: BGB324; BGB-324; BGB 324; R 428; R-428; R428; 1-(6,7-dihydro-5H-benzo[2,3]cyclohepta[2,4-d]pyridazin-3-yl)-3-N-[(7S)-7-pyrrolidin-1-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]-1,2,4-triazole-3,5-diamine. CAS No. 1037624-75-1. Molecular formula: C30H34N8. Mole weight: 506.658. | |
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