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| Product | Description | |
|---|---|---|
| Midostaurin | Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ , Syk , Flk-1 , Akt , PKA , c-Kit , c-Fgr , c-Src , FLT3 , PDFRβ and VEGFR1/2 with IC 50 s ranging from 22-500 nM [1] [2]. Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PKC412; CGP 41251. CAS No. 120685-11-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10230. |  |
| Midostaurin hydrate | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. |  |
| 3-Hydroxy Midostaurin | 3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC 50 s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412 [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CGP52421. CAS No. 179237-49-1. Pack Sizes: 1 mg. Product ID: HY-108263. | |
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