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| Product | Description | |
|---|---|---|
| MIM1 | MIM-1 is an inhibitor of myeloid cell factor 1 ( Mcl-1 ). Uses: Scientific research. Group: Signaling pathways. Alternative Names: Inhibitor of Mcl-1. CAS No. 509102-00-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16695. |  |
| MIM1 | MIM1 is a small molecule inhibitor of Mcl-1 (IC50= 4.8 uM) by selectively targets the BH3-binding pocket. Uses: Mcl-1 inhibitor. Synonyms: AC1OBINW; MIM1; MIM 1; MIM-14-[[(2-cyclohexylimino-4-methyl-1,3-thiazol-3-yl)amino]methylidene]-2,3-dihydroxycyclohexa-2,5-dien-1-one. Grades: ≥98%. CAS No. 509102-00-5. Molecular formula: C17H21N3O3S. Mole weight: 347.43. |  |
| MIM1 (4-(E)-[[(2Z)-2-cyclohexylimino)-4-m ethyl-1, 3-thiazol-3 (2H) -yl] imino] methyl] benzene-1, 2,3-triol) | MIM1 (4-(E)-[[(2Z)-2-cyclohexylimino)-4-m ethyl-1, 3-thiazol-3 (2H) -yl] imino] methyl] benzene-1, 2,3-triol). Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. Molecular Formula: C17H21N3O3S, Biological Activity: Inhibitor of Mcl-1; selectively targets the BH3-binding pocket. Induces caspase-3/7 activation and cell death in Mcl-1-dependent leukemia cells. Also blocks Mcl-1-mediated suppression of tBID-induced Bax activation in vitro. US Biological Life Sciences. |  Worldwide |
| Mcl-1 Inhibitor, MIM1 (4-((E)-((Z)-2-(cyclohexylimino)-4-methylthiazol-3(2H)-ylimino)methyl)benzene-1,2,3-triol, Mcl-1 Inhibitor Molecule 1) | A cell-permeable thiazolyl iminopyrogallol that selectively neutralizes Mcl-1, but not Bcl-XL, antiapoptotic activity by directly targeting Mcl-1 BH3-binding site, effectively competing against Bid BH3 sequence for Mcl-1 binding (IC50 = 4.8uM). Shown to induce caspase 3/7 activation and cell death in Mcl-1-, but not Bcl-XL-, dependent B-ALL cultures (6% vs. 82% survival, respectively; 10uM). In comparison, ABT-737 affects only Bcl-XL-, but not Mcl-1-, dependent B-ALL cells. Neither MIM1 nor ABT-737 significantly affects the survival of wild-type or Bax-/-Bak-/- MEF. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences. | Worldwide |
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