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| Product | Description | |
|---|---|---|
| Miransertib | Miransertib (ARQ-092) is a potent, orally active, selective and allosteric Akt inhibitor with IC 50 s of 2.7 nM, 14 nM and 8.1 nM for Akt1 , Akt2 , Akt3 , respectively. Miransertib is also a potent the AKT1-E17K mutant protein inhibitor and has the potential for PI3K/AKT-driven tumors and Proteus syndrome research [1]. Miransertib is effective against Leishmania [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ARQ-092. CAS No. 1313881-70-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19719. |  |
| Miransertib | Miransertib Inhibitor. Uses: Scientific use. Product Category: T3467. CAS No. 1313881-70-7. |  |
| Miransertib hydrochloride | Miransertib hydrochloride (ARQ-092 hydrochloride) is a potent, orally active, selective and allosteric Akt inhibitor with IC 50 s of 2.7 nM, 14 nM and 8.1 nM for Akt1 , Akt2 , Akt3 , respectively. Miransertib hydrochloride is also a potent the AKT1-E17K mutant protein inhibitor and has the potential for PI3K/AKT-driven tumors and Proteus syndrome research [1]. Miransertib hydrochloride is effective against Leishmania [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ARQ-092 hydrochloride. CAS No. 1313883-00-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19719A. | |
| Miransertib hydrochloride | Miransertib is an orally bioavailable and selective AKT pathway inhibitor that suppresses AKT1, 2, 3 isoforms. It binds to both the active and inactive forms of AKT. Miransertib inhibits PIK3CA/AKT1 mutant dependent kinase signaling and exhibits antitumor activity. Synonyms: Miransertib; ARQ 092 HCl; Miransertib HCl; 3-[3-[4-(1-aminocyclobutyl)phenyl]-5-phenylimidazo[4,5-b]pyridin-2-yl]pyridin-2-amine hydrochloride. CAS No. 1313883-00-9. Molecular formula: C27H25ClN6. Mole weight: 468.98. |  |
| ARQ-092 | ARQ-092, also called as Miransertib, is an oral activie, potent and selective AKT inhibitor with IC50=5.0 nM against AKT1, 4.5 nM against AKT2 and 16 nM against AKT3. ARQ-092 inhibits the PI3K/AKT signaling pathway due to inhibition of the activity of AKT in a non-ATP competitive manner. This may lead to the reduction in tumor cell proliferation and the induction of tumor cell apoptosis. Synonyms: 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine; ARQ092; ARQ-092; ARQ 092; Miransertib. Grades: >98%. CAS No. 1313881-70-7. Molecular formula: C27H24N6. Mole weight: 432.53. | |
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