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| Product | Description | |
|---|---|---|
| Mirogabalin besylate | Mirogabalin besylate is a selective and orally available ligand for the α2δ subunit of voltage-gated calcium channels , with K d s of 13.5 nM, 22.7 nM, 27 nM, and 47.6 nM for human α2δ-1, human α2δ-2, rat α2δ-1, and rat α2δ-2, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DS 5565 besylate. CAS No. 1138245-21-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-108006. |  |
| Mirogabalin besylate | Mirogabalin besylate is a selective and orally available ligand for the voltage-gated calcium channel α2δ subunit and is being developed for the treatment of pain associated with diabetic peripheral neuropathy, fibromyalgia and post-herpetic neuralgia. Synonyms: DS-5565; DS 5565; DS5565; A-2000700. Grades: 98%. CAS No. 1138245-21-2. Molecular formula: C18H25NO5S. Mole weight: 367.5. |  |
| Mirogabalin | This active molecular is an α2δ-1 ligand being developed for pain associated with diabetic peripheral neuropathy, fibromyalgia, and postherpetic neuralgia which related to related to drugs such as gabapentin and pregabalin. Mirogabalin binds to the α2δ calcium channels (1 and 2) and was estimated to be much more potent than pregabalin. In Nov 2015, a Japanese company named Daiichi Sankyo plans a phase III trial for Postherpetic neuralgia and Neuropathic pain (in patients with diabetic peripheral neuropathy and renal impairment) in Japan. In May 2016, Pharmacokinetics and adverse data from a phase I trial in volunteers presented at the 35th Annual Scientific Meeting of the American Pain Society. Uses: Treatment of diabetic peripheral neuropathic pain. Synonyms: 2-[(1R,5S,6S)-6-(aminomethyl)-3-ethyl-6-bicyclo[3.2.0]hept-3-enyl]acetic acid, DS-5565,CAS#1138245-21-2 ( Mirogabalin besylate). Grades: 98%. CAS No. 1138245-13-2. Molecular formula: C12H19NO2. Mole weight: 209.29. | |
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