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| Product | Description | |
|---|---|---|
| MK-886 | MK-886 (L 663536) is a potent, cell-permeable and orally active FLAP ( IC 50 of 30 nM) and leukotriene biosynthesis ( IC 50 s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 is also a non-competitive PPARα antagonist and can induce apoptosis [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: L 663536. CAS No. 118414-82-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14166. |  |
| MK-886 | This active molecular is a leukotriene antagonist with the IC50 of 3 nM in human polymorphonuclear leukocytes. MK-886 also inhibits PPARα activation. Inhibition of 5-lipoxygenase-activating protein (FLAP) leads to inhibited 5-lipoxygenase (5-LOX), and this may help in treating atherosclerosis. MK-886 and Celecoxib have an inhibitory effect on the growth of pancreatic cancer cell line SW1990 and angiogenesis. In Mar 1996, an animal study had been added to the Ischaemic Heart Disease pharmacodynamics section. Uses: Ischaemic heart disease. Synonyms: MK-886; MK886; MK 886; L-663,536; L663,536; L 663,536; L-663536; L663536; L 663536; 3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2,2-dimethylpropanoic acid,L-663,536,118427-55-7( MK-886 Sodium Salt). Grades: 98%. CAS No. 118414-82-7. Molecular formula: C27H34ClNO2S. Mole weight: 472.08. |  |
| MK-886 (3-[tert-Butylthio-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic Acid, Sodium Salt) | Binds to 5-lipoxygenase-activating protein with high affinity and prevents the activation of 5-lipoxygenase, thus inhibiting the biosynthesis of leukotrienes. Group: Biochemicals. Alternative Names: 3-[tert-Butylthio-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic Acid, Sodium Salt. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| MK-886 sodium salt | MK-886 is a leukotriene inhibitor that works by blocking 5-lipoxygenase activating protein (FLAP). MK886 also inhibits PPAR alpha by a non-competitive mechanism. Uses: Lipoxygenase inhibitors. Synonyms: MK-886 sodium; MK 886 sodium; MK886 sodium; 3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2,2-dimethylpropanoate sodium salt. Grades: ≥99%. CAS No. 118427-55-7. Molecular formula: C27H33ClNO2S·Na. Mole weight: 494.1. | |
| MK-886 sodium salt | MK-886 sodium salt. Group: Biochemicals. Alternative Names: 3-[tert-Butylthio-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic acid, sodium salt. Grades: Highly Purified. CAS No. 118427-55-7. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C27H33ClNNaO2S. US Biological Life Sciences. | Worldwide |
| MK 886 Sodium Salt (3-(1-(4-chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid, L 663536, L-663536, MK-886) | MK 886 Sodium Salt (3-(1-(4-chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid, L 663536, L-663536, MK-886). Group: Biochemicals. Alternative Names: Sodium;3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2,2-dimethylpropanoate. Grades: Highly Purified. CAS No. 118427-55-7. Pack Sizes: 25mg. Molecular Formula: C27 H33 ClNO 2 , Molecular Weight: 494.1. US Biological Life Sciences. | Worldwide |
| MKC-8866 | MKC-8866, also known as IRE1-IN-8866, is an inhibitor of IRE1 RNase activity. MKC8866 strongly inhibits prostate cancer (PCa) tumor growth as monotherapy in multiple preclinical models in mice and shows synergistic antitumor effects with current PCa drugs. Interestingly, global transcriptomic analysis reveal that IRE1α-XBP1s pathway activity is required for c-MYC signaling, one of the most highly activated oncogenic pathways in PCa. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MKC-8866; MKC 8866; MKC8866; IRE1-IN-8866; IRE1IN8866; IRE1 IN 8866; IRE1-IN8866; IRE1-IN 8866; IRE1IN-8866; IRE1IN 8866. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1338934-59-0. Molecular formula: C18H19NO7. Mole weight: 361.35. Purity: >98%. IUPACName: 7-Hydroxy-6-methoxy-4-methyl-3-(2-morpholino-2-oxoethyl)-2-oxo-2H-chromene-8-carbaldehyde. Canonical SMILES: O=CC1=C(O)C(OC)=CC2=C1OC(C(CC(N3CCOCC3)=O)=C2C)=O. Product ID: ACM1338934590. Alfa Chemistry ISO 9001:2015 Certified. |  |
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