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| Product | Description | |
|---|---|---|
| ML 145 | ML 145. Group: Biochemicals. Grades: Purified. CAS No. 1164500-72-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| 1-Propenylmagnesium bromide, 0.5 M in THF | 100ml Pack Size. Group: Building Blocks, Catalysts, Organics. Formula: C3H5BrMg. CAS No. 14092-04-7. Prepack ID 90026453-100ml. Molecular Weight 145.28. See USA prepack pricing. |  |
| (1R,3R)-Ferroptosis inducer-1 | (1R,3R)-Ferroptosis inducer-1 is an isomer of Ferroptosis inducer-1 (HY-145595). (1R,3R)-Ferroptosis inducer-1 (compound BX-3a) is a Ferroptosis inducer with antitumor potential [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2375357-97-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145595A. |  |
| 2'-Hydroxy-5'-methylacetophenone | 2'-Hydroxy-5'-methylacetophenone belongs to the class of organic compounds known as alkyl-phenylketones. These are aromatic compounds containing a ketone substituted by one alkyl group, and a phenyl group. Uses: Scientific research. Group: Signaling pathways. CAS No. 1450-72-2. Pack Sizes: 10 mM * 1 mL; 1 g. Product ID: HY-W100681. | |
| 2-Pyridinecarbohydrazide | 2-Pyridinecarbohydrazide is a building block extensively used in various fields of synthesis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1452-63-7. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-W010341. | |
| 3,4-Dicaffeoylquinic acid | 3,4-Dicaffeoylquinic acid (3,4-Di-O-caffeoylquinic acid), naturally isolated from Laggera alata , has antioxidative, DNA protective, neuroprotective and hepatoprotective properties. 3,4-Dicaffeoylquinic acid exerts apoptosis-mediated cytotoxicity and α-glucosidase inhibitory effects. 3,4-Dicaffeoylquinic acid possesses a unique mechanism of anti-influenza viral activity, that is, enhancing viral clearance by increasing TRAIL [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: 3,4-Di-O-caffeoylquinic acid; Isochlorogenic acid B. CAS No. 14534-61-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N0057. | |
| 3-Methylpyrazole | 3-Methylpyrazole is used as a nitrification inhibitor of nitrification in soil [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1453-58-3. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-66054. | |
| 5-(methoxymethyl)-1,3,4-thiadiazol-2-amine | 5-(methoxymethyl)-1,3,4-thiadiazol-2-amine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 5-(methoxymethyl)-1,3,4-thiadiazol-2-amine, 15884-86-3, AG-E-08105, 5-Methoxymethyl-[1,3,4]thiadiazol-2-ylamine, 5-(methoxymethyl)-1,3,4-thiadiazole-2-ylamine, ZERO/006070, AC1LD3WS, SureCN2201689, Oprea1_094729, Oprea1_573295, MLS000038509, CTK4C9861, MolPort-000-147-512, BB_SC-5171, HMS2181H10, ALBB-009378, ANW-73905, BBL008482, SBB007576, STK501883. Product Category: Heterocyclic Organic Compound. CAS No. 15884-86-3. Molecular formula: C4H7N3OS. Mole weight: 145.182880 [g/mol]. Purity: 0.96. IUPACName: 5-(methoxymethyl)-1,3,4-thiadiazol-2-amine. Canonical SMILES: COCC1=NN=C(S1)N. Product ID: ACM15884863. Alfa Chemistry ISO 9001:2015 Certified. |  |
| AFN-1252 | AFN-1252 is an orally active and selective inhibitor of FabI, an essential enzyme in fatty acid biosynthesis in Staphylococcus spp. AFN-1252 exhibits exquisite and highly selective activity against Staphylococcus spp. AFN-1252 exhibits typical MIC90 values of ?0.015 ?g/ml against diverse clinical isolates of S. aureus. AFN-1252 is efficacious in a mouse model of septicemia providing 100% protection from an otherwise lethal peritoneal infection of S. aureus Smith[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: API-1252; Debio 1452. CAS No. 620175-39-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-16911. | |
| Allylmagnesium bromide, 1M solution in diethyl ether | 100ml Pack Size. Group: Building Blocks, Grignard Reagents, Organics. Formula: C3H5BrMg. CAS No. 1730-25-2. Prepack ID 90026482-100ml. Molecular Weight 145.28. See USA prepack pricing. | |
| Amisulpride hydrochloride | Amisulpride hydrochloride is a dopamine D 2 /D 3 receptor antagonist with K i s of 2.8 and 3.2 nM for human dopamine D 2 and D 3 , respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DAN 2163 hydrochloride. CAS No. 81342-13-4. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14545A. | |
| ASP5878 | ASP5878 is an oral active inhibitor of FGFR 1, 2, 3, and 4 , with IC 50 values of 0.47 nM, 0.6 nM, 0.74 nM and 3.5 nM for FGFR 1, 2, 3, and 4 kinase activity. ASP5878 has potential antineoplastic activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1453208-66-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19983. | |
| Atomoxetine hydrochloride | Atomoxetine (Tomoxetine) hydrochloride is a selective noradrenaline reuptake inhibitor with K i values of 5 nM, 77 nM and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride is a potent Na + channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Tomoxetine hydrochloride; (R)-Tomoxetine hydrochloride; LY 139603. CAS No. 82248-59-7. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-17385. | |
| Bisindolylmaleimide X hydrochloride | Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective protein kinase C (PKC) inhibitor. Bisindolylmaleimide X hydrochloride is a potent cyclin-dependent kinase 2 (CDK2) antagonist with an IC50 of 200 nM[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BIM-X hydrochloride; Ro31-8425 hydrochloride. CAS No. 145317-11-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-108136A. | |
| Bupranolol | Bupranolol is an orally active, competitive and non-selective β-adrenoceptor antagonist without intrinsic sympathomimetic activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 14556-46-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-A0252. | |
| Cambinol | Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 ?M and 59 ?M, respectively. Cambinol is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 14513-15-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100732. | |
| Candesartan Cilexetil | Candesartan Cilexetil (TCV-116) is an angiotensin II receptor inhibitor. Candesartan Cilexetil ameliorates the pulmonary fibrosis and has antiviral and skin wound healing effect. Candesartan Cilexetil can be used for the research of high blood pressure [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TCV-116. CAS No. 145040-37-5. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-17505. | |
| Cetuximab | Cetuximab is a remarkable monoclonal antibody widely employed in the research of epidermal growth factor receptor (EGFR). Synonyms: N-(2-phenylethoxy)-1-pyridin-4-ylmethanimine; MLS002608064; AC1L5VKQ; CHEMBL1736329; MolPort-001-793-950; HMS3092B19. Grade: 95%. CAS No. 205923-56-4. Molecular formula: C6484H10042N1732O2023S36. Mole weight: 145KDa. |  |
| Chloropyrazine | Chloropyrazine (Pyrazin-2-yl chloride) is a member of pyrazines, can be used for the synthesis of active compounds [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Pyrazin-2-yl chloride. CAS No. 14508-49-7. Pack Sizes: 10 mM * 1 mL; 5 g. Product ID: HY-Y0109. | |
| Dexmedetomidine hydrochloride | Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of α2-adrenoceptor , with a K i of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (+)-Medetomidine hydrochloride; (S)-Medetomidine hydrochloride. CAS No. 145108-58-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-17034A. | |
| Elevenostat | Elevenostat (JB3-22) is a selective HDAC11 inhibitor with an IC50 of 0.235 μM. Elevenostat can induce apoptosis of multiple myeloma cells and has anti-tumor effect. In addition, Elevenostat inhibits the maturation of mouse oocytes[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: JB3-22. CAS No. 1454902-97-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145757. | |
| Estramustine | Estramustine is an antineoplastic agent. Estramustine depolymerizes microtnbules by binding to tubulin 1 , exhibits antimitotic activity with an IC 50 value of ~16 μM for mitosis of DU 145 cells. Estramustine blocks cells at mitosis in prostate tumor xenografts [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2998-57-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103711. | |
| Gamithromycin | Gamithromycin. Group: Biochemicals. Alternative Names: (2R, 3S, 4R, 5S, 8R, 10R, 11R, 12S, 13S, 14R)-13-[(2, 6-Dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranosyl)oxy]-2-ethyl-3, 4, 10-trihydroxy-3, 5, 8, 10, 12, 14-hexamethyl-7-propyl-11-[[3, 4, 6-trideoxy-3-(dimethylamino)-b-D-xylo-hexopyranosyl]oxy]-1-oxa-7-azacyclopentadecan-15-one; ML 1709460. Grades: Highly Purified. CAS No. 145435-72-9. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C40H76N2O12. US Biological Life Sciences. | Worldwide |
| Gamithromycin | Gamithromycin is an antimicrobial agent which can inhibit the growth of MmmSC strains B237 and Tan8 with MICs of 0.00012 and 0.00006 μg/mL, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ML-1709460. CAS No. 145435-72-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108365. | |
| Gamithromycin | Gamithromycin is a semi-synthetic macrolide derived from erythromycin. It is used to prevent and treat calf pneumonia caused by Mannheimia hemolyticus, Pasteurella multocida, Histophilus and Mycoplasma. Uses: Anti-bacterial agents. Synonyms: ML 1709460. Grade: >95% by HPLC. CAS No. 145435-72-9. Molecular formula: C40H76N2O12. Mole weight: 777.03. | |
| GTS-21 dihydrochloride | GTS-21 dihydrochloride is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist with anti - inflammatory and cognition - enhancing activities. GTS-21 dihydrochloride is also a α4β2 ( K i =20 nM for humanα4β2) and 5-HT3A receptor ( IC 50 =3.1 μM) antagonist [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DMXB-A; DMBX-anabaseine. CAS No. 156223-05-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14564A. | |
| HG-9-91-01 | HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIK) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SIK inhibitor 1. CAS No. 1456858-58-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15776. | |
| HUHS015 | HUHS015 is a potent prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitor with an IC50 of 0.67?M for PCA-1[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1453097-13-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100199. | |
| Idazoxan hydrochloride | Idazoxan hydrochloride (RX 781094 hydrochloride) is an α 2 -adrenoceptor antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like agents (IMs). Idazoxan hydrochloride also improves motor symptoms in Parkinsons disease, L-DOPA-induced dyskinesias, and experimental Parkinsonism [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RX 781094 hydrochloride. CAS No. 79944-56-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-14561A. | |
| KAN0438757 | KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 ?M[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1451255-59-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112808. | |
| LHF-535 | LHF-535 is an antiviral agent extracted from patent WO2013123215A2, Compound 38, has EC50s of <1 ?M, <1 ?M, <1 ?M, and 1-10 ?M for Lassa, Machupo, Junin, and VSVg virus, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1450929-77-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112762. | |
| Lorlatinib | Lorlatinib (PF-06463922) is a selective, orally active, brain-penetrant and ATP-competitive ROS1/ALK inhibitor with anticancer activity. Lorlatinib has K i s of <0.025 nM, <0.07 nM, and 0.7 nM for ROS1, wild type ALK, and ALK L1196M , respectively. Lorlatinib targets to EML4-ALK, and inhibits ALK phosphorylation with IC 50 s of 15-43 nM (ALK L1196 ), 14-80 nM (ALK G1269A ), 38-50 nM (ALK 1151Tins ), 77-113 nM (ALK G1202R ), respectively [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-06463922. CAS No. 1454846-35-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12215. | |
| LP-935509 | LP-935509 is an orally active, potent, selective, ATP-competitive and brain-penetrant inhibitor of adaptor protein-2 associated kinase 1 (AAK1) with an IC50 of 3.3 nM and a Ki of 0.9 nM, respectively. LP-935509 is also a potent inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of GAK (IC50=320 nM). LP-935509 shows antinociceptive activity. LP-935509 can be used for neuropathic pain and SARS-CoV-2 research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1454555-29-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-117626. | |
| LS-102 | LS-102 is a selective E3 ubiquitin ligase synoviolin (Syvn1) inhibitor. LS-102 inhibits the autoubiquitination of synoviolin with an IC50 of 35 ?M. LS-102 has the potential for rheumatoid arthritis treatment[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1456891-34-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-135844. | |
| lunresertib | lunresertib (RP-6306) is a potent, selective and orally active PKMYT1 inhibitor with an IC 50 of 14 nM. lunresertib shows a high degree of selectivity over other kinases in cellular binding assays. lunresertib shows anticancer effects [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RP-6306. CAS No. 2719793-90-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145817A. | |
| LY3009120 | LY3009120 (DP-4978) is a pan RAF inhibitor which inhibits BRAF V600E , BRAF WT and CRAF WT with IC 50 s of 5.8, 9.1 and 15 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DP-4978. CAS No. 1454682-72-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12558. | |
| Methotrexate disodium | Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Amethopterin disodium; CL14377 disodium; WR19039 disodium. CAS No. 7413-34-5. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-14519A. | |
| Mitiglinide calcium | Mitiglinide Calcium (KAD-1229 anhydrous), an insulinotropic agent, is an ATP-sensitive K + (K ATP ) channel antagonist. Mitiglinide Calcium is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell K ATP channel). Mitiglinide Calcium can be used for the research of type 2 diabetes [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KAD-1229 anhydrous; S21403 anhydrous. CAS No. 145525-41-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg. Product ID: HY-17398. | |
| MRT199665 | MRT199665 is a potent and ATP-competitive, selective MARK/SIK/AMPK inhibitor with IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPK?1/AMPK?2, and SIK1/SIK2/SIK3, respectively[1]. MRT199665 causes apoptosis in MEF2C-activated human acute myeloid leukemias (AML) cells[2]. MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370[3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1456858-57-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-120877. | |
| Nacubactam | Nacubactam (OP0595 free acid) is a potent non-β-lactam-β-lactamase inhibitor with activity against class A and class C β-lactamases. Nacubactam (OP0595 free acid) acts as a penicillin binding protein (PBP) 2-active antibacterial, and gives β-lactamase-independent potentiation of β-lactams targeting other PBPs [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: OP0595 free acid. CAS No. 1452458-86-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-109008. | |
| NNC-711 | NNC-711 is a potent and selective inhibitor of GAT-1 (GABA transporter 1) with IC 50 values of 0.04, 0.38, 171, 1700, 349, 622 μM for human GAT-1, rat GAT-1, rGAT-2, hGAT-3, rGAT-3, hBGT-3, respectively. NNC-711 has anticonvulsant and analgesic effect in vivo and exhibits cognition-enhancing activity [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NO-711 hydrochloride. CAS No. 145645-62-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg. Product ID: HY-103506. | |
| NU9056 | NU9056 is a potent and selective Tip60 (KAT5) histone acetyltransferase inhibitor with an [1][2] of 2 μM. NU9056 shows >16-fold selectivity for Tip60 over PCAF, p300 and GCN5. NU9056 induces apoptosis of prostate cancer cells[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1450644-28-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110127. | |
| NXT629 | NXT629 is a potent, selective, and competitive PPAR-? antagonist, with an IC50 of 77 nM for human PPAR?, shows high selectivity over other nuclear hormone receptor, such as PPAR?, PPAR?, ER?, GR and TR?, IC50s are 6.0, 15, 15.2, 32.5 and >100 ?M, respectively[1]. NXT629 has potent anti-tumor activity and inhibits experimental metastasis of cancer cell in animal models[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1454925-59-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114263. | |
| Olitigaltin | TD139 is a synthetic galectin-3 inhibitor. TD139 has high affinity for galectin-3 with a Kd of 68 nM, a Kd of 0.22 ?M for galectin-1, and a Kd of 38 ?M for galectin-7[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TD139; GB0139. CAS No. 1450824-22-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19940. | |
| Orexin receptor antagonist 2 | Orexin receptor antagonist 2 (compound 30) is a potent orexin receptor antagonist with pK i s of 7.69 and 9.78. Orexin receptor antagonist 2 has the potential for the research of insomnia [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1457940-75-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-136922. | |
| Phenazopyridine hydrochloride | Phenazopyridine hydrochlorideis a competitive SARM1 inhibitor, with IC 50 145 μM. Phenazopyridine hydrochlorideis a TRPM8 antagonist. Phenazopyridine hydrochloride has a local anesthetic/analgesic effect. Phenazopyridine hydrochlorideis used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine hydrochloridecan promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 136-40-3. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B0985. | |
| Picolinamide | Picolinamide (2-Picolinamide) is an inhibitor of Poly(ADP-ribose) synthetase of nuclei from rat pancreatic islet cells [1] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2-Picolinamide. CAS No. 1452-77-3. Pack Sizes: 10 mM * 1 mL; 5 g; 10 g; 25 g; 50 g. Product ID: HY-101020. | |
| Pimavanserin hemitartrate | Pimavanserin (ACP-103) hemitartrate is a potent 5-HT 2A receptor inverse agonist with pIC 50 and pK i of 8.73 and 9.3, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ACP-103 hemitartrate. CAS No. 706782-28-7. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14557A. | |
| Povorcitinib phosphate | Povorcitinib (INCB54707) phosphate is a potent and selective JAK1 inhibitor that effectively reduces abscesses and inflammatory nodules. Povorcitinib phosphate can be used to study cutaneous lupus erythematosus (CLE) and lichen planus (LP) (information extracted from patent WO2021076124A1) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: INCB54707 phosphate. CAS No. 1637677-33-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145588A. | |
| Pregnenolone | Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor , inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication [1] [2]. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels [3]. Uses: Scientific research. Group: Natural products. Alternative Names: 3β-Hydroxy-5-pregnen-20-one. CAS No. 145-13-1. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-B0151. | |
| PU-WS13 | PU-WS13 is a selective Grp94 inhibitor, with an EC50 of 0.22 ?M. Uses: Scientific research. Group: Signaling pathways. CAS No. 1454619-14-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-18680. | |
| Ravoxertinib | Ravoxertinib (GDC-0994) is an orally active ERK kinase inhibitor with an IC50 of 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GDC-0994. CAS No. 1453848-26-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15947. | |
| Reboxetine mesylate | Reboxetine mesylate (FCE20124 mesylate) is a potent, selective, and specific noradrenaline reuptake inhibitor (NARI) for the research of depression. Reboxetine mesylate inhibits the uptake of norepinephrine, with a K i of 8 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FCE20124 mesylate; PNU155950E mesylate. CAS No. 98769-84-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-14560C. | |
| Rizatriptan benzoate | Rizatriptan benzoate is the agonist for 5-HT 1B and 5-HT 1D. Rizatriptan benzoate has a peripheral vasoconstrictive effect, penetrates the intact blood-brain barrier, and inhibits pain neurotransmission in the central nervous system [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK 462. CAS No. 145202-66-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-B0206. | |
| Roginolisib | Roginolisib (MSC2360844; IOA-244) is a potent, orally active and selective PI3Kδ inhibitor, with an IC 50 of 145 nM. Roginolisib shows highly selective against a panel of 278 additional kinases [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MSC2360844; IOA-244. CAS No. 1305267-37-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135827. | |
| SAR-20347 | SAR-20347 is an inhibitor of TYK2, JAK1, JAK2 and JAK3 with IC50s of 0.6, 23, 26 and 41 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1450881-55-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100895. | |
| SBI-425 | SBI-425 is an orally active and potent TNAP (tissue-nonspecific alkaline phosphatase) inhibitor (IC50=16 nM). SBI-425 inhibits TNAP in the vasculature, improving cardiovascular parameters and survival[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1451272-71-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124756. | |
| (S)-Donepezil | (S)-Donepezil is a S-enantiomer of Donepezil (HY-14566). Donepezil is a specific and potent AChE inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (S)-E2020 free base. CAS No. 142057-80-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14566A. | |
| SH-4-54 | SH-4-54 is a STAT inhibitor that binds to STAT3 and STAT5 with KDs of 300, 464 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1456632-40-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16975. | |
| Sodium tert-pentoxide 2.5m (30%) in THF | 100ml Pack Size. Group: Building Blocks, Organics. Formula: C5H11NaO. CAS No. 14593-46-5. Prepack ID 90026387-100ml. Molecular Weight 110.13. See USA prepack pricing. | |
| Sophocarpine monohydrate | Sophocarpine (monohydrate) is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. Sophocarpine (monohydrate) significantly inhibits the growth of gastric cancer (GC) cells through multiple mechanisms such as induction of autophagy , activation of cell apoptosis and down-regulation of cell survival PI3K/AKT signaling pathway. Sophocarpine (monohydrate) has been demonstrated to have anti-tumor activity in various cancer cells, including hepatocellular carcinoma, prostate cancer and colorectal cancer [1]. Uses: Scientific research. Group: Natural products. CAS No. 145572-44-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0103A. | |
| SR-3029 | SR-3029 is a potent and ATP competitive CK1? and CK1? inhibitor, with IC50s of 44 nM and 260 nM, respectively, and Kis of 97 nM for both kinases. Uses: Scientific research. Group: Signaling pathways. CAS No. 1454585-06-8. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100011. | |
| TAK-243 | TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor ( IC 50 =1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. TAK-243 (MLN7243) induces endoplasmic reticulum (ER) stress, abrogates NF-κB pathway activation and promotes apoptosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MLN7243. CAS No. 1450833-55-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100487. | |
| TAS-119 | TAS-119 is a potent, selective and orally active Aurora A inhibitor with an IC 50 of 1.0 nM. TAS-119 shows high selectivity for Aurora A over other protein kinases, including Aurora B ( IC 50 of 95 nM). TAS-119 has potent antitumor activites [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1453099-83-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137377. | |
| Tasosartan | Tasosartan is a long-acting angiotensin II ( AngII ) receptor antagonist. Uses: Scientific research. Group: Signaling pathways. Alternative Names: WAY-ANA 756. CAS No. 145733-36-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-A0250. | |
| Tauro-β-muricholic acid sodium | Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC 50 of 40 μM [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: T-βMCA sodium. CAS No. 145022-92-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135103. | |
| Taurocholic acid sodium | Taurocholic acid sodium (Sodium taurocholate) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid sodium has immunoregulation effect [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Sodium taurocholate; N-Choloyltaurine sodium. CAS No. 145-42-6. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-N0545. | |
| Tegaserod | Tegaserod is an orally active serotonin receptor 4 ( HTR4 ; 5-HT 4 R ) agonist and a 5-HT 2B receptor antagonist. Tegaserod has pK i s of 7.5, 8.4 and 7.0 for human recombinant 5-HT 2A , 5-HT 2B and 5-HT 2C receptors, respectively. Tegaserod causes tumor cell apoptosis , blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation. Tegaserod has anti-tumor activity and has the potential for irritable bowel syndrome (IBS) research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 145158-71-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14153. | |
| Tetomilast | Tetomilast (OPC-6535) is a PDE4 inhibitor with potential for the research of inflammatory bowel disease (IBD) and chronic obstructive pulmonary disease (COPD). Uses: Scientific research. Group: Signaling pathways. Alternative Names: OPC-6535. CAS No. 145739-56-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105092. | |
| Tiagabine hydrochloride | Tiagabine hydrochloride is an anticonvulsant agent and a selective inhibitor of the GAT-1 GABA transporter with a Ki of ?0.1 μM. Tiagabine hydrochloride potently and selectively inhibits GABA reuptake with IC 50 s of 67, 446 and 182 nM for [3H] GABA uptake in synaptosomes, neurons and glia, respectively. Tiagabine hydrochloride has neuroprotective properties [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NO050328 hydrochloride; NO328 hydrochloride; TGB hydrochloride. CAS No. 145821-59-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0696A. | |
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