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ML 289. Group: Biochemicals. Grades: Purified. CAS No. 1382481-79-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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ML 289
ML-289 is a negative allosteric modulator of mGlu3 with IC50 value of 0.66 μM. It displays 15-fold selectivity over mGlu2 and inactivity against mGlu5.1. Synonyms: VU0463597, VU 0463597, VU-0463597, ML-289, ML 289; ML289; [ (3R) -3- (Hydroxymethyl) -1-pipridinyl][4-[2- (4-methoxyphenyl) ethynyl]phenyl]methanone. Grades: ≥98% by HPLC. CAS No. 1382481-79-9. Molecular formula: C22H23NO3. Mole weight: 349.42.
3-(1-Benzyl-1H-benzimidazol-2-yl)propan-1-ol
3-(1-Benzyl-1H-benzimidazol-2-yl)propan-1-ol. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3-(1-benzyl-1H-benzimidazol-2-yl)propan-1-ol, 121356-81-8, 3-(1-Benzyl-1H-benzoimidazol-2-yl)-propan-1-ol, 3-(1-benzylbenzimidazol-2-yl)propan-1-ol, 3-[1-benzylbenzimidazol-2-yl]propan-1-ol, BAS 00942990, CBMicro_035095, AC1MFJ13, SureCN9740603, Oprea1_289974, Oprea1_417506, MLS001212823, STOCK3S-47798, CTK4B2326, MolPort-000-255-407, HMS2836G06, SBB082386, STK726799, ZINC37866295, AKOS000646979. Product Category: Heterocyclic Organic Compound. CAS No. 121356-81-8. Molecular formula: C17H18N2O. Mole weight: 266.337620 [g/mol]. Purity: 0.96. IUPACName: 3-(1-benzylbenzimidazol-2-yl)propan-1-ol. Canonical SMILES: C1=CC=C(C=C1)CN2C3=CC=CC=C3N=C2CCCO. Density: 1.14g/cm³. Product ID: ACM121356818. Alfa Chemistry ISO 9001:2015 Certified.
4-Ethylresorcinol, a derivative of resorcinol, can act as substrates of tyrosinase. 4-Ethylresorcinol possess hypopigmentary effects. 4-Ethylresorcinol attenuates mRNA and protein expression of tyrosinase-related protein (TRP)-2, and possessed antioxidative effect by inhibiting lipid peroxidation [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 2896-60-8. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-W015782.
A-967079
A-967079 is a selective TRPA1 receptor antagonist with IC 50 s of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively, and has good penetration into the CNS. Uses: Scientific research. Group: Signaling pathways. CAS No. 1170613-55-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108463.
Arimoclomol maleate
Arimoclomol maleate (BRX-220) is an orally active co-inducer of heat shock proteins ( HSP ) [1]. Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system [2].Arimoclomol maleate can be used for the study of Niemann - Pick disease type C. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BRX-220. CAS No. 289893-26-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106443A.
BBO-8520
BBO-8520 is a direct small molecule covalent inhibitor targeting KRAS G12C with high oral availability. BBO-8520 has the characteristics of KRAS G12C (OFF) inhibitor and the function of blocking KRAS G12C (ON) signal. BBO-8520 inhibits cell proliferation by inhibiting KRAS G12C (ON) by binding GTP protein. BBO-8520 can block RAS-RAF1 interaction and return KRAS G12C to the inactive (OFF) state [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2893809-51-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158107.
Canertinib dihydrochloride
Canertinib dihydrochloride (CI-1033 dihydrochloride) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC 50 s of 7.4 and 9 nM. Canertinib dihydrochloride is active against vaccinia virus respiratory infection in mice [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CI-1033 dihydrochloride; PD-183805 dihydrochloride. CAS No. 289499-45-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-10367A.
Dalpiciclib hydrochloride
Dalpiciclib (SHR-6390) hydrochloride is an orally active and highly selective inhibitor of CDK4 and 6 with IC 50 values of 12.4?nM and 9.9?nM, respectively [1] [2]. Dalpiciclib hydrochloride shows antitumor activity against breast cancer and esophageal squamous cell carcinoma [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SHR-6390 hydrochloride. CAS No. 2891598-76-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114338A.
E7820
E7820 (ER68203-00), an orally active aromatic sulfonamide derivative, is a unique angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. E7820 inhibits rat aorta angiogenesis with an IC 50 of 0.11 μg/ml. E7820 modulates α-1, α-2, α-3, and α-5 integrin mRNA expression. Antiangiogenic and antitumor activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ER68203-00. CAS No. 289483-69-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14571.
L-Allothreonine
L-Allothreonine (H-allo-Thr-OH) is an endogenous metabolite. Uses: Scientific research. Group: Natural products. Alternative Names: H-allo-Thr-OH. CAS No. 28954-12-3. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-W008315.
Mizoribine
Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC 50 of approximately 100 μM for anti-HCV activity. Immunosuppressant [1]. Mizoribine, an IMPDH inhibitor, inhibits replication of SARS-CoV with IC 50 s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively [2]. Uses: Scientific research. Group: Natural products. Alternative Names: NSC 289637; HE 69. CAS No. 50924-49-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17470.
Oridonin
Oridonin (NSC-250682), a diterpenoid isolated from Rabdosia rubescens , acts as an inhibitor of AKT , with IC 50 s of 8.4 and 8.9 μM for AKT1 and AKT2; Oridonin possesses anti-tumor, anti-bacterial and anti-inflammatory effects. Uses: Scientific research. Group: Natural products. Alternative Names: NSC-250682; Isodonol. CAS No. 28957-04-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-N0004.
PD-L1-IN-2
PD-L1-IN-2 is a potential tumor immunological agent by inhibiting PD-L1. PD-L1-IN-2 is a Naamidine J derivative and exerts antitumor effects in vivo by reducing PD-L1 expression and enhancing tumor-infiltrating T-cell immunity. PD-L1-IN-2 is used for colorectal cancer research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2894733-91-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-149830.
Pyrimidine
Pyrimidine is an endogenous metabolite. Uses: Scientific research. Group: Natural products. CAS No. 289-95-2. Pack Sizes: 10 mM * 1 mL; 1 g. Product ID: HY-Y0519.
Senicapoc
Senicapoc (ICA-17043) is a potent and selective Gardos channel (Ca 2+ -activated K + channel; KCa3.1 ) blocker with an IC 50 of 11 nM. Senicapoc blocks Ca 2+ -induced rubidium flux from human RBCs with an IC 50 value of 11 nM and inhibits RBC dehydration with IC 50 of 30 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ICA-17043. CAS No. 289656-45-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50694.
TBPB
TBPB is an allosteric M1 mAChR agonist(EC50=289 nM) that regulates amyloid processing and produces antipsychotic-like activity in rats. Uses: Scientific research. Group: Signaling pathways. CAS No. 634616-95-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-14562.
TN1
TN1 is a potent fetal hemoglobin ( HbF ) inducer. Uses: Scientific research. Group: Signaling pathways. CAS No. 289479-94-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-100826.
Treprostinil sodium
Treprostinil (UT-15) sodium is a potent DP1 and EP2 agonist with EC 50 values of 0.6±0.1 and 6.2±1.2 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: UT-15 sodium. CAS No. 289480-64-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16504.
Ursodeoxycholic acid sodium
Ursodeoxycholic acid (Ursodeoxycholate) sodium is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid sodium acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 ( TGR5 , GPCR19 ) and the farnesoid X receptor ( FXR ). Ursodeoxycholic acid sodium can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Ursodeoxycholate sodium; Ursodiol sodium; UCDA sodium. CAS No. 2898-95-5. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-13771A.
VU0463597
VU0463597, also known as ML-289, is a negative allosteric modulator of mGlu3 (IC50 = 0.66 μM) that displays 15-fold selectivity over mGlu2 and inactivity against mGlu5.1. Uses: Designed for use in research and industrial production. Additional or Alternative Names: VU0463597, VU 0463597, VU-0463597, ML-289, ML 289; ML289. Product Category: Others. Appearance: Solid powder. CAS No. 1382481-79-9. Molecular formula: C22H23NO3. Mole weight: 349.43. Purity: >98%. IUPACName: [(3R)-1-({4-[2-(4-methoxyphenyl)ethynyl]phenyl}carbonyl)piperidin-3-yl]methanol. Canonical SMILES: OC[C@H]1CN(C(C2=CC=C(C#CC3=CC=C(OC)C=C3)C=C2)=O)CCC1. Product ID: ACM1382481799. Alfa Chemistry ISO 9001:2015 Certified.
Watermelon ketone
Watermelon ketone is fragrance chemical compound with special odorant which has been widely used in the fragrance industry, extracted from patent CN 103058984 A. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 7-Methyl-2H-1,5-benzodioxepin-3(4H)-one. CAS No. 28940-11-6. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-W016622.
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