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| Product | Description | |
|---|---|---|
| ML-SI3 | ML-SI3 is a chemical compound which acts as an "antagonist" (i.e. channel blocker) of the TRPML family of calcium channels, with greatest activity at the TRPML1 channel, although it also blocks the related TRPML2 and TRPML3 channels with lower affinity. It is used for research into the role of TRPML1 and its various functions in lysosomes and elsewhere in the body. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ML-SI3; ML SI3; MLSI3; ML SI 3; MLSI-3. Product Category: Antagonists. Appearance: Solid powder. CAS No. 891016-02-7. Molecular formula: C23H31N3O3S. Mole weight: 429.58. Purity: >98%. IUPACName: N-(2-[4-(2-Methoxyphenyl)-1-piperazinyl]cyclohexyl)benzenesulfonamide. Canonical SMILES: O=S(C1=CC=CC=C1)(NC2C(N3CCN(C4=CC=CC=C4OC)CC3)CCCC2)=O. Product ID: ACM891016027. Alfa Chemistry ISO 9001:2015 Certified. |  |
| ML-SI3 | ML-SI3 is a mixture of cis/trans ML-SI3 (HY-139426A), which is a TRPML1/2 channel inhibitor with IC50s of 4.7 ?M and 1.7 ?M, respectively. ML-SI3 also inhibits lysosomal calcium efflux and blocks downstream TRPML1-mediated autophagy. The cis/trans ML-SI3 (HY-139426A) components of ML-SI3 are TRPML2 activators with EC50s of 3.3 ?M and 9.4 ?M, respectively[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ML-SI3 (cis/trans mix). CAS No. 891016-02-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139426. |  |
| ML-SI3 | ML-SI3 is an antagonist of the TRPML family of calcium channels. ML-SI3 can prevent lysosomal calcium efflux and has been reported to block downstream TRPML1-mediated induction of autophagy. Synonyms: N- [2- [4- (2-methoxyphenyl) -1-piperazinyl] cyclohexyl] benzenesulfonamide. CAS No. 891016-02-7. Molecular formula: C23H31N3O3S. Mole weight: 429.58. |  |
| (1R,2R)-ML-SI3 | (1R,2R)-ML-SI3 is an isomer of ML-SI3 and a potent inhibitor of three isoforms of TRPML. (1R,2R)-ML-SI3 inhibits TRPMLs with IC50s of 1.6 ?M (TRPML1), 2.3 ?M (TRPML2), and 12.5 ?M (TRPML3), respectively[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (-)-trans-ML-SI3. CAS No. 2418594-00-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134819A. | |
| (rel)-ML-SI3 | (rel)-ML-SI3 is one of the active ingredients of ML-SI3 (HY-139426) (another component is (cis)-ML-SI3) that targets three isoforms of TRPML. (rel)-ML-SI3 is an inhibitor of TRPML1 and TRPML3 (IC50=3.1 ?M/28.5 ?M), and a potent activator of TRPML2 (EC50=3.3 ?M)[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: trans-ML-SI3. CAS No. 2108567-79-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139426A. | |
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