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ML-SI3 ML-SI3 is a chemical compound which acts as an "antagonist" (i.e. channel blocker) of the TRPML family of calcium channels, with greatest activity at the TRPML1 channel, although it also blocks the related TRPML2 and TRPML3 channels with lower affinity. It is used for research into the role of TRPML1 and its various functions in lysosomes and elsewhere in the body. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ML-SI3; ML SI3; MLSI3; ML SI 3; MLSI-3. Product Category: Antagonists. Appearance: Solid powder. CAS No. 891016-02-7. Molecular formula: C23H31N3O3S. Mole weight: 429.58. Purity: >98%. IUPACName: N-(2-[4-(2-Methoxyphenyl)-1-piperazinyl]cyclohexyl)benzenesulfonamide. Canonical SMILES: O=S(C1=CC=CC=C1)(NC2C(N3CCN(C4=CC=CC=C4OC)CC3)CCCC2)=O. Product ID: ACM891016027. Alfa Chemistry — ISO 9001:2015 Certified. Alfa Chemistry.
ML-SI3 ML-SI3 is an antagonist of the TRPML family of calcium channels. ML-SI3 can prevent lysosomal calcium efflux and has been reported to block downstream TRPML1-mediated induction of autophagy. Synonyms: N- [2- [4- (2-methoxyphenyl) -1-piperazinyl] cyclohexyl] benzenesulfonamide. CAS No. 891016-02-7. Molecular formula: C23H31N3O3S. Mole weight: 429.58. BOC Sciences 8

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