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| Product | Description | |
|---|---|---|
| ML364 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| ML364 | ML364 is a selective ubiquitin specific peptidase 2 (USP2) inhibitor (IC50=1.1 ?M) with anti-proliferative activity, which direct binds to USP2 (Kd=5.2 ?M), induces an increase in cellular cyclin D1 degradation and causes cell cycle arrest. ML364 increases the levels of mitochondrial ROS and decreases in the intracellular content of ATP[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1991986-30-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-100900. |  |
| ML364 | ML364 is a small molecule, reversible inhibitor of the deubiquitinase USP2, that has an IC50 value of 1.1 μM in a fluorescence-based assay using di-ubiquitin substrates. Consistent with the role of cyclin D1 in DNA damage response, ML364 also caused a decrease in homologous recombination-mediated DNA repair. Synonyms: 2-[(4-Methylphenyl)sulfonylamino]-N-(4-phenyl-1,3-thiazol-2-yl)-4-(trifluoromethyl)benzamide; ML364; ML 364; ML-364. CAS No. 1991986-30-1. Molecular formula: C24H18F3N3O3S2. Mole weight: 517.54. |  |
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