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| Product | Description | |
|---|---|---|
| MM-102 | MM-102, as a MLL1 mimetic, shows high binding affinities to WDR5 with IC50 of 2.9 nM and Ki of < 1 nM. Synonyms: MM-102; MM102; MM 102; HMTase Inhibitor IX. Grades: >98%. CAS No. 1417329-24-8. Molecular formula: C35H49F2N7O4. Mole weight: 669.8. |  |
| MM-102 | MM-102 Inhibitor. Uses: Scientific use. Product Category: T8768. CAS No. 1883545-52-5. |  |
| MM-102 Trifluoroacetate | MM102 is a WDR5/MLL interaction inhibitor with IC50 value of 2.4 nM. It can inhibit cell growth and induce apoptosis in leukemia cells harbouring MLL1 fusion proteins. Synonyms: MM 102; MM102; MM-102; 1-[[(2S)-5-[(Aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]-cyclopentanecarboxamide trifluoroacetate. Grades: ≥98% by HPLC. CAS No. 1883545-52-5. Molecular formula: C35H49F2N7O4.CF3CO2H. Mole weight: 783.83. | |
| HMTase Inhibitor IX, MM-102 (Histone Methyltransferase Inhibitor IX, MM102, (S) -N- (bis (4-Fluoro phenyl ) methy l )-1- (2- (2-ethyl -2-isobutyramidobutanamid o)-5-guanidinopentanamido) cyclopentane carboxami de , TFA) | A cell-permeable peptidomimetic that prevents MLL1 (Mixed Lineage Leukemia 1) from complex assembling with WDR5 (Trp-Asp Repeat Domain 5), RbBP5 (Retinoblastoma Binding Protein 5), and ASH2L (Absent Small or Homeotic-2-Like) for enhanced H3K4 methyltransferase activity (IC50 = 0.4nM). Shown to reduce HoxA9 and Meis-1 mRNA expression in myeloblasts derived from MLL1-AF9-transduced murine bone marrow cells (50uM for 96 h) and preferentially inhibit the growth of MLL1-AF4-harboring MV4;11 and MLL1-ENL-harboring KOPN8 leukemia cultures (GI50 in 7 days = 25uM) via apoptosis induction, while exhibiting much reduced potency against BCR-ABL-dependent K562 cells (GI50 in 7 days = 84uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O? ยท CF?CO?H. US Biological Life Sciences. |  Worldwide |
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