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| Product | Description | |
|---|---|---|
| MMP Inhibitor II | MMP Inhibitor II (compound 4e) is a potent, reversible pan- MMP inhibitor with IC 50 values of 24 nM, 18.4 nM, 30 nM, and 2.7 nM for MMP-1,MMP-3, MMP-7, and MMP-9, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 203915-59-7. Pack Sizes: 1 mg. Product ID: HY-119423. |  |
| MMP Inhibitor II | MMP Inhibitor II is an inhibitor of matrix metalloproteinase MMP-1/MMP-3/MMP-7/MMP-9 with IC50 values of 24, 18.4, 30 and 2.7 nM, respectively. Synonyms: Matrix Metalloproteinase Inhibitor II; NHDDPC; PG 117025; PGE 4410186; N-hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethyl-1,3-diazinane-2-carboxamide. Grades: ≥95%. CAS No. 203915-59-7. Molecular formula: C21H27N3O8S2. Mole weight: 513.6. |  |
| MMP Inhibitor II - CAS 203915-59-7 | The MMP Inhibitor II, also referenced under CAS 203915-59-7, controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Group: Fluorescence/luminescence spectroscopy. |  |
| MMP Inhibitor III - CAS 927827-98-3 | The MMP Inhibitor III, also referenced under CAS 927827-98-3, controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Group: Fluorescence/luminescence spectroscopy. | |
| MMP-2 Inhibitor II | MMP-2 Inhibitor II is an irreversible inhibitor of matrix metalloproteinase-2 (MMP-2) with Ki value of 2.4 μM. It also less potently inhibits MMP-1 and MMP-7. Synonyms: ?Matrix Metalloproteinase-2 Inhibitor II; (4- (4- (Methanesulfonamido) phenoxy) phenylsulfonyl) methyloxirane. Grades: ≥98%. CAS No. 869577-51-5. Molecular formula: C16H17NO6S2. Mole weight: 383.4. | |
| MMP-2 Inhibitor II - CAS 869577-51-5 | The MMP-2 Inhibitor II, also referenced under CAS 869577-51-5, controls the biological activity of MMP-2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Group: Fluorescence/luminescence spectroscopy. | |
| MMP-2 Inhibitor III - CAS 704888-90-4 | The MMP-2 Inhibitor III, also referenced under CAS 704888-90-4, controls the biological activity of MMP-2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Group: Fluorescence/luminescence spectroscopy. | |
| MMP-2/MMP-3 Inhibitor III, PD166793 - CAS 199850-67-4 | The MMP-2/MMP-3 Inhibitor III, PD166793, also referenced under CAS 199850-67-4, controls the biological activity of MMP-2/MMP-3. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Group: Fluorescence/luminescence spectroscopy. | |
| MMP-2/MMP-9 Inhibitor II | MMP-2/MMP-9 inhibitor II is a potent inhibitor of matrix metalloproteinase MMP-2/MMP-9 with IC50 values of 17 and 30 nM, respectively. It was shown to suppress lung colonization of Lewis lung carcinoma cells and inhibit tumor-induced angiogenesis, tumor growth, and liver metastasis in mouse models. Synonyms: Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor II; (2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide. Grades: ≥98%. CAS No. 193807-60-2. Molecular formula: C21H20N2O4S. Mole weight: 396.46. | |
| MMP-2/MMP-9 Inhibitor II - CAS 193807-60-2 | The MMP-2/MMP-9 Inhibitor II, also referenced under CAS 193807-60-2, controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Group: Fluorescence/luminescence spectroscopy. | |
| MMP-2/MMP-9 Inhibitor III | The MMP-2/MMP-9 Inhibitor III controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Group: Fluorescence/luminescence spectroscopy. | |
| MMP-2/MMP-9 Inhibitor III trifluoroacetate salt | MMP-2/MMP-9 inhibitor III is a cyclic peptide inhibitor of matrix metalloproteinase MMP-2/MMP-9 with IC50 values of 10-20 μM for both. Synonyms: Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor III. Grades: ≥95%. Molecular formula: C52H71N13O14S2·xCF3COOH. Mole weight: 1166.33. | |
| MMP-3 Inhibitor II - CAS 161314-17-6 | The MMP-3 Inhibitor II, also referenced under CAS 161314-17-6, controls the biological activity of MMP-3. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Group: Fluorescence/luminescence spectroscopy. | |
| MMP-9 Inhibitor II | The MMP-9 Inhibitor II controls the biological activity of MMP-9. This small molecule/inhibitor is primarily used for Biochemicals applications. Group: Fluorescence/luminescence spectroscopy. | |
| MMP-9 Inhibitor II (MMP-9 PEX Inhibitor) | This compound is a cell-permeable, selective, and reversible thiopyrimidone MMP-9 allosteric inhibitor that binds specifically to the non-catalytic site of MMP-9 at the PEX domain with a =2.1uM and thereby disrupts MMP-9 homodimerization and its cross-talk with CD44 and the EGFR-MAPK signaling pathway. It does not bind to the PEX domain of MMP-2 or MT1-MMP and it is shown to decrease MMP-9 mediated cell migration in COS-1 cells at 100uM. Also, it inhibits cell migration and invasion of HT-1080 and MDA-MB-435 human cancer cells in a dose-dependent manner from 0.1 to 100M, without altering MMP-9 expression or proteolytic activity in HT-1080 cells. In addition, it attenuates both primary tumor growth and metastasis in vivo in a mouse model without obvious toxicity (20mg/kg, 6 days/week, i.v. and i.t.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| 2-MPPA | 2-MPPA is a selective glutamate carboxypeptidase II (GCP II) inhibitor (IC50 = 90 nM), which is selective for GCP II over NMDA, kainate and AMPA glutamate receptors and MMP-1, -2, -3, -7, -9, ACE and NEP metalloproteases. 2-MPPA can be used in the treatment of neurological disorders associated with excessive activation of glutamatergic systems. Attenuates glutamate transmission resulting in the relief of neuropathic pain. This compound has neuroprotective properties. Synonyms: 2-(3-Mercaptopropyl)pentanedioic acid; 2-MPPA; 2 MPPA; 2MPPA. CAS No. 254737-29-6. Molecular formula: C8H14O4S. Mole weight: 206.26. | |
| H-Cys-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Cys-OH (Disulfide bond) | It is a cyclic peptide inhibitor for matrix metalloproteinases (MMP-2) and MMP-9. Synonyms: CTTHWGFTLC, CYCLIC; L-cysteinyl-L-threonyl-L-threonyl-L-histidyl-L-tryptophyl-glycyl-L-phenylalanyl-L-threonyl-L-leucyl-L-cysteine (1->10)-disulfide; MMP-2/MMP-9 Inhibitor III; Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor III. Grades: ≥90%. CAS No. 244082-19-7. Molecular formula: C52H71N13O14S2. Mole weight: 1166.33. | |
| Imidapril | Imidapril (TA-6366 free base) is an orally active angiotensin-converting enzyme (ACE) and MMP-9 inhibitor. Imidapril suppresses the conversion of angiotensin I to angiotensin II and thereby reduces total peripheral resistance and systemic blood pressure. Imidapril can be used for hypertension, type 1 diabetic, nephropathy and chronic heart failure research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TA-6366 free base. CAS No. 89371-37-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-B1451A. | |
| Imidapril hydrochloride | Imidapril hydrochloride (TA-6366) is an orally active angiotensin-converting enzyme (ACE) and MMP-9 inhibitor. Imidapril hydrochloride suppresses the conversion of angiotensin I to angiotensin II and thereby reduces total peripheral resistance and systemic blood pressure. Imidapril hydrochloride can be used for hypertension, type 1 diabetic, nephropathy and chronic heart failure research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TA-6366. CAS No. 89396-94-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1451. | |
| Marimastat ( (2S, 3R) -N4-[ (1S) -2, 2-Dimethyl-1-[ (-[ (methylamino) carbonyl]propyl]-N1, 2-dihydroxy-3- (2-methylpropyl) butanediamide, BB-2516, TA-2516) | A broad spectrum matrix metalloprotease (MMP) inhibitor with IC50 values of 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively. It covalently binds to the zinc(II) ion in the active site of MMPs, thereby inhibiting the action of MMPs, inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Matrix Metalloproteinase-13 (HisoTag) from Human, Recombinant | Matrix metalloproteinases are members of a unique family of proteolytic enzymes that have a zinc ion at their active sites and can degrade collagens, elastin and other components of the extracellular matrix (ECM). These enzymes are present in normal healthy individuals and have been shown to have an important role in processes such as wound healing, pregnancy, and bone resorption. However, overexpression and activation of MMPs have been linked with a range of pathological processes and disease states involved in the breakdown and remodeling of the ECM. Such diseases include tumor invasion and metastasis, rheumatoid arthritis, periodontal disease and vascular pr..., a ca2+- and zn2+- binding catalytic domain, a hinge region, and a c-terminal hemopexin domain. hydrolyzes collagen type ii 5-6 times faster than collagens type i and iii. exhibits high activity towards gelatin and degrades α1-antichymotrypsin and plasminogen activator inhibitor-2. Group: Enzymes. Synonyms: Collagenase-3; Matrix metallopeptidase 13; MMP13; CLG3; MANDP1; MMP-13. Purity: >90% by SDS-PAGE. Matrix Metalloproteinase. Mole weight: 60 kDa. Activity: >50 mU/mg protein. Storage: < -70°C; Avoid freeze/thaw. Form: Liquid. Source: S. frugiperda. Species: Human. Collagenase-3; Matrix metallopeptidase 13; MMP13; CLG3; MANDP1; MMP-13. Cat No: NATE-0859. |  |
| NF-κB Activation Inhibitor III | NF-κB activation inhibitor III inhibits TNF-α-induced MMP-9 protein expression via blocking NF-κB activity. It has been used to suppress invasion and metastasis of tumor cells. Uses: Matrix metalloproteinase inhibitors. Synonyms: SM-7368; SM 7368; SM7368; 3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide. Grades: ≥99%. CAS No. 380623-76-7. Molecular formula: C10H5ClN4O5S. Mole weight: 328.7. | |
| NNGH | NNGH is a cell-permeable inhibitor of matrix metalloproteinases (MMPs). It has been used to study the role of MMP-3 (stromelysin 1) in biological systems. Synonyms: N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid; ??Matrix Metalloproteinase-3 Inhibitor II; MMP-3 Inhibitor II; N-hydroxy-2-[(4-methoxyphenyl)sulfonyl-(2-methylpropyl)amino]acetamide. Grades: ≥99%. CAS No. 161314-17-6. Molecular formula: C13H20N2O5S. Mole weight: 316.4. | |
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