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| Product | Description | |
|---|---|---|
| Monactin | A member of the macrotetrolide complex produced by a range of streptomyces species; a monovalent cation ionophore with high selectivity for ammonium and potassium; inhibits T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and IFN-&gamma. It is also resistant to gram-positive bacteria and mycobacteria. Synonyms: 4, 13, 22, 31, 37, 38, 39, 40-Octaoxapentacyclo[32.2.1.17, 10.116, 19.125, 28]tetracontane-3, 12, 21, 30-tetrone, 5-ethyl-2, 11, 14, 20, 23, 29, 32-heptamethyl-, (1R, 2R, 5R, 7R, 10S, 11S, 14S, 16S, 19R, 20R, 23R, 25R, 28S, 29S, 32S, 34S)-; Akd-1B. Grades: >95% by HPLC. CAS No. 7182-54-9. Molecular formula: C41H66O12. Mole weight: 750.95. |  |
| Monactin (5-demethyl-5-ethylnonactin, Antibiotic AKD 1B) | Monactin is a member of the macrotetrolide complex produced by a range of Streptomyces species. Unlike nonactin, monactin has not previously been available for intensive investigation. Early literature reported that the related dinactin is a monovalent cation ionophore with high selectivity for ammonium and potassium. Monactin inhibits T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and interferon-gamma. Group: Biochemicals. Alternative Names: 5-demethyl-5-ethylnonactin, Antibiotic AKD 1B. Grades: Highly Purified. CAS No. 7182-54-9. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Nonactin | Nonactin is the smallest member of the macrotetrolide complex produced by a range of Streptomyces species. Originally the name, nonactin, reflected the lack of biological activity. The literature is somewhat confusing in this respect, as virtually all sources of nonactin are contaminated with small amounts of the much more active monactin. The BioAustralis nonactin has been purifed to remove traces of other biologically-active macrotetrolides. Like the other macrotetrolides, nonactin is a monovalent cation ionophore with high selectivity for ammonium and potassium. Group: Biochemicals. Grades: Highly Purified. CAS No. 6833-84-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
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