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| Product | Description | |
|---|---|---|
| Monocrotaline | A toxic pyrrolizidine alkaloid isolated from Crotalaria spp. It is used for inducing pulmonary diseases in rats. Group: Biochemicals. Alternative Names: (3R, 4R, 5R, 13aR, 13bR) -4, 5, 8, 10, 12, 13, 13a, 13b-Octahydro-4, 5-dihydroxy-3, 4, 5-trimethyl-2H- [1, 6]dioxacycloundecino [2, 3, 4-gh]pyrrolizine-2, 6 (3H) -dione; (13α,14α)-14,19-dihydro-12,13-dihydroxy-20-Norcrotalanan-11,15-dione; (-)-Monocrotaline; Monocrotalin; NSC 28693; Crotaline. Grades: Highly Purified. CAS No. 315-22-0. Pack Sizes: 10mg, 50mg, 100mg, 250mg. Molecular Formula: C16H23NO6, Melting Point: >140°C (dec.). US Biological Life Sciences. |  Worldwide |
| Monocrotaline | Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid. Monocrotaline inhibits OCT-1 and OCT-2 with IC 50 s of 36.8 μM and 1.8 mM, respectively. Monocrotaline has antitumor activity and is cytotoxic to hepatocellular carcinoma cells. Monocrotaline is used to induce a model of pulmonary hypertension in rodents. [2][6][8]. Uses: Scientific research. Group: Natural products. Alternative Names: Crotaline. CAS No. 315-22-0. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-N0750. |  |
| Monocrotaline (Crotaline) | Monocrotaline (Crotaline). Group: Biochemicals. Alternative Names: Monocrotalin. Grades: Plant Grade. CAS No. 315-22-0. Pack Sizes: 20mg. Molecular Formula: C16H23NO6, Molecular Weight: 325.357. US Biological Life Sciences. | Worldwide |
| Monocrotaline N-Oxide | Monocrotaline N-Oxide, a monocrotaline metabolite, leads to DNA adduct formation in vivo [1]. Uses: Scientific research. Group: Natural products. CAS No. 35337-98-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N6828. | |
| (13α, ?14α)?-14, ?19-?Dihydro-?12, ?13-?[methylenebis(oxy)?]?-?20-?norcrotalanan-?11, ?15-?dione | (13α, ?14α)?-14, ?19-?Dihydro-?12, ?13-?[methylenebis(oxy)?]?-?20-?norcrotalanan-?11, ?15-?dione is an intermediate in synthesizing Monocrotaline-d4 (M526002), a labelled Monocrotaline (M526000) which is a toxic pyrrolizidine alkaloid isolated from Crotalaria spp. It is used for inducing pulmonary diseases in rats. Group: Biochemicals. Grades: Highly Purified. CAS No. 121719-98-0. Pack Sizes: 500mg, 1g. Molecular Formula: C17H23NO6. US Biological Life Sciences. | Worldwide |
| (1R,?7aR)?-2,?3,?5,?7a-?Tetrahydro-?1-?hydroxy-1H-?pyrrolizine-?7-?carboxylic Acid Methyl Ester | (1R,?7aR)?-2,?3,?5,?7a-?Tetrahydro-?1-?hydroxy-1H-?pyrrolizine-?7-?carboxylic Acid Methyl Ester is an intermediate in synthesizing Monocrotaline-d4 (M526002), a labelled Monocrotaline (M526000) which is a toxic pyrrolizidine alkaloid isolated from Crotalaria spp. It is used for inducing pulmonary diseases in rats. Group: Biochemicals. Grades: Highly Purified. CAS No. 25471-68-5. Pack Sizes: 10mg, 25mg. Molecular Formula: C9H13NO3, Molecular Weight: 183.2. US Biological Life Sciences. | Worldwide |
| (2R, 3R, 4R) -2, 3, 4-Trimethyl-2, 3- (methylenedioxy) pentanedioic Acid | (2R, 3R, 4R) -2, 3, 4-Trimethyl-2, 3- (methylenedioxy) pentanedioic Acid is an intermediate in synthesizing Monocrotaline-d4 (M526002), a labelled Monocrotaline (M526000) which is a toxic pyrrolizidine alkaloid isolated from Crotalaria spp. It is used for inducing pulmonary diseases in rats. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 250mg, 500mg. Molecular Formula: C9H14O6. US Biological Life Sciences. | Worldwide |
| 2-tert-Butyldi methyl silyloxyethyl Tosylate-d2 | 2-tert-Butyldi methyl silyloxyethyl Tosylate-d2 is an intermediate in synthesizing Monocrotaline-d4 (M526002), a labelled Monocrotaline (M526000) which is a toxic pyrrolizidine alkaloid isolated from Crotalaria spp. It is used for inducing pulmonary diseases in rats. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 50mg, 100mg. Molecular Formula: C15H24D2O4SSi. US Biological Life Sciences. | Worldwide |
| BUR1 | BUR1 is a BMP upregulator (EC 50 : 98 nM) and activates BMPRII signalling. BUR1 induces BMP2 and PTGS2 expression. BUR1 reversed pulmonary arterial pressure in Monocrotaline (HY-N0750) induced rats [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 23000-46-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-121025. | |
| L-902,688 | L-902,688 is a highly potent agonist of the human PGE2 receptor subtype EP4. It attenuated right ventricular fibrosis in a monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) rat model. L-902,688 exhibits a neuroprotective effect on ischemic stroke by reducing MMP-3/-9 and BBB damage. Synonyms: (5R)-5-[(E,3R)-4,4-difluoro-3-hydroxy-4-phenylbut-1-enyl]-1-[6-(2H-tetrazol-5-yl)hexyl]pyrrolidin-2-one. Grades: ≥98%. CAS No. 634193-54-7. Molecular formula: C21H27F2N5O2. Mole weight: 419.5. |  |
| Nolomirole hydrochloride | Nolomirole is a Alpha 2 adrenergic receptor and Dopamine D2 receptor agonist. Nolomirole can attenuate the heart failure signs in the monocrotaline-induced congestive heart failure. Phase-III clinical trials for Congestive heart failure in Europe was discontinued. Uses: Heart failure. Synonyms: CHF1035; CHF-1035; CHF 1035; Nolomirole Hydrochloride; Nolomirole HCl; 6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2-diyl bis(2-methylpropanoate) hydrochloride. Grades: 98%. CAS No. 138531-51-8. Molecular formula: C19H28ClNO4. Mole weight: 369.89. | |
| PRX 08066 | PRX 08066, a selective 5-hydroxytryptamine receptor 2B(5-HT2BR) antagonist, causes selective vasodilation of pulmonary arteries. Its IC50 value is 3.4 nM. It can potentially inhibit the pathologic 5-HT-induced vascular muscularization and is developed to treat for pulmonary arterial hypertension (PAH). It reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats. It shows effects on the vascular muscularization induced by 5-HT in the in vitro studies. It inhibits 5-HT-induced mitogen-activated protein kinase activation and markedly reduces thymidine incorporation in Chinese hamster ovary cells expressing the human 5-HT2BR in vitro. It decrea...ts and mice without affecting the systemic mean arterial pressure in the animals. It is also found to have anti-proliferative and anti-fibrotic effects. It was developed by Allergan company and is in clinical phase 2 with no progression. Uses: Prx 08066 can potentially inhibit the pathologic 5-ht-induced vascular muscularization and is developed to treat for pulmonary arterial hypertension (pah). it is also found to have anti-proliferative and anti-fibrotic effects. Synonyms: PRX-08066; PRX 08066; PRX08066. 5-[[4-[(6-chlorothieno[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]methyl]-2-fluorobenzonitrile. Grades: >98%. CAS No. 866206-54-4. Molecular formula: C19H17ClFN5S. Mole weight: 401.89. | |
| senecionine N-oxygenase | A flavoprotein. NADH cannot replace NADPH. While pyrrolizidine alkaloids of the senecionine and monocrotaline types are generally good substrates (e.g. senecionine, retrorsine and monocrotaline), the enzyme does not use ester alkaloids lacking an hydroxy group at C-7 (e.g. supinine and phalaenopsine), 1,2-dihydro-alkaloids (e.g. sarracine) or unesterified necine bases (e.g. senkirkine) as substrates. Senecionine N-oxide is used by insects as a chemical defense: senecionine N-oxide is non-toxic, but it is bioactivated to a toxic form by the action of cytochrome P-450 oxidase when absorbed by insectivores. Group: Enzymes. Synonyms: senecionine monooxygenase (N-oxide-forming); SNO. Enzyme Commission Number: EC 1.14.13.101. CAS No. 220581-68-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0700; senecionine N-oxygenase; EC 1.14.13.101; 220581-68-0; senecionine monooxygenase (N-oxide-forming); SNO. Cat No: EXWM-0700. |  |
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