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(4S)-limonene synthase A recombinant enzyme (also known as a monoterpene synthase or cyclase) from the grand fir (Abies grandis) requires Mn2+ and K+ for activity. Mg2+ is essentially ineffective as the divalent metal ion cofactor. Group: Enzymes. Synonyms: (-)-(4S)-limonene synthase; 4S-(-)-limonene synthase; geranyldiphosphate diphosphate lyase (limonene forming); geranyldiphosphate diphosphate lyase [cyclizing, (4S)-limonene-forming]; geranyl-diphosphate diphosphate-lyase [cyclizing; (-)-(4S)-limonene-forming]. Enzyme Commission Number: EC 4.2.3.16. CAS No. 110639-20-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5172; (4S)-limonene synthase; EC 4.2.3.16; 110639-20-8; (-)-(4S)-limonene synthase; 4S-(-)-limonene synthase; geranyldiphosphate diphosphate lyase (limonene forming); geranyldiphosphate diphosphate lyase [cyclizing, (4S)-limonene-forming]; geranyl-diphosphate diphosphate-lyase [cyclizing; (-)-(4S)-limonene-forming]. Cat No: EXWM-5172. Creative Enzymes
amorpha-4,11-diene synthase Requires Mg2+ and Mn2+ for activity. This is a key enzyme in the biosynthesis of the antimalarial endoperoxide artemisinin. Catalyses the formation of both olefinic [e.g. amorpha-4,11-diene, amorpha-4,7(11)-diene, γ-humulene and β-sesquiphellandrene] and oxygenated (e.g. amorpha-4-en-7-ol) sesquiterpenes, with amorpha-4,11-diene being the major product. When geranyl diphosphate is used as a substrate, no monoterpenes are produced. Group: Enzymes. Synonyms: amorphadiene synthase. Enzyme Commission Number: EC 4.2.3.24. CAS No. 259213-60-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5181; amorpha-4,11-diene synthase; EC 4.2.3.24; 259213-60-0; amorphadiene synthase. Cat No: EXWM-5181. Creative Enzymes
β-phellandrene synthase (neryl-diphosphate-cyclizing) The enzyme from Solanum lycopersicum has very poor affinity with geranyl diphosphate as substrate. Catalyses the formation of the acyclic myrcene and ocimene as major products in addition to β-phellandrene. Group: Enzymes. Synonyms: phellandrene synthase 1; PHS1; monoterpene synthase PHS1. Enzyme Commission Number: EC 4.2.3.51. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5211; β-phellandrene synthase (neryl-diphosphate-cyclizing); EC 4.2.3.51; phellandrene synthase 1; PHS1; monoterpene synthase PHS1. Cat No: EXWM-5211. Creative Enzymes
chrysanthemyl diphosphate synthase Requires a divalent metal ion for activity, with Mg2+ being better than Mn2+. Chrysanthemyl diphosphate is a monoterpene with a non-head-to-tail linkage. It is unlike most monoterpenoids, which are derived from geranyl diphosphate and have isoprene units that are linked head-to-tail. The mechanism of its formation is similar to that of the early steps of squalene and phytoene biosynthesis. Chrysanthemyl diphosphate is the precursor of chrysanthemic acid, the acid half of the pyrethroid insecticides found in chrysanthemums. Group: Enzymes. Synonyms: CPPase. Enzyme Commission Number: EC 2.5.1.67. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2804; chrysanthemyl diphosphate synthase; EC 2.5.1.67; CPPase. Cat No: EXWM-2804. Creative Enzymes
lavandulyl diphosphate synthase Lavandulyl diphosphate is a monoterpene with a non-head-to-tail linkage. It is unlike most monoterpenoids, which are derived from geranyl diphosphate and have isoprene units that are linked head-to-tail. When this enzyme is incubated with dimethylallyl diphosphate and isopentenyl diphosphate, it also forms the regular monoterpene geranyl diphosphate. The enzyme from Artemisia tridentata (big sagebrush) forms both lavandulyl diphosphate and chrysanthemyl diphosphate (see EC 2.5.1.67, chrysanthemyl diphosphate synthase) when dimethylally diphosphate is the sole substrate. Group: Enzymes. Synonyms: FDS-5. Enzyme Commission Number: EC 2.5.1.69. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2806; lavandulyl diphosphate synthase; EC 2.5.1.69; FDS-5. Cat No: EXWM-2806. Creative Enzymes
(+)-menthofuran synthase A heme-thiolate protein (P-450). The conversion of substrate into product involves the hydroxylation of the syn-methyl (C9), intramolecular cyclization to the hemiketal and dehydration to the furan. This is the second cytochrome P-450-mediated step of monoterpene metabolism in peppermint, with the other step being catalysed by EC 1.14.13.47, (S)-limonene 3-monooxygenase. Group: Enzymes. Synonyms: menthofuran synthase; (+)-pulegone 9-hydroxylase; (+)-MFS; cytochrome P450 menthofuran synthase. Enzyme Commission Number: EC 1.14.13.104. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0703; (+)-menthofuran synthase; EC 1.14.13.104; menthofuran synthase; (+)-pulegone 9-hydroxylase; (+)-MFS; cytochrome P450 menthofuran synthase. Cat No: EXWM-0703. Creative Enzymes
myrcene synthase A recombinant enzyme (also known as a monoterpene synthase or cyclase) from the grand fir (Abies grandis) requires Mn2+ and K+ for activity. Mg2+ is essentially ineffective as the divalent metal ion cofactor. Group: Enzymes. Enzyme Commission Number: EC 4.2.3.15. CAS No. 197462-59-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5164; myrcene synthase; EC 4.2.3.15; 197462-59-2. Cat No: EXWM-5164. Creative Enzymes
R-linalool synthase Geranyl diphosphate cannot be replaced by isopentenyl diphosphate, dimethylallyl diphosphate, farnesyl diphosphate or geranylgeranyl diphosphate as substrate. Requires Mg2+ or Mn2+ for activity. Unlike many other monoterpene synthases, only a single product, (3R)-linalool, is formed. Group: Enzymes. Synonyms: (3R)-linalool synthase; (-)-3R-linalool synthase. Enzyme Commission Number: EC 4.2.3.26. CAS No. 254993-26-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5183; R-linalool synthase; EC 4.2.3.26; 254993-26-5; (3R)-linalool synthase; (-)-3R-linalool synthase. Cat No: EXWM-5183. Creative Enzymes
S-linalool synthase Requires Mn2+ or Mg2+ for activity. Neither (S)- nor (R)-linalyl diphosphate can act as substrate for the enzyme from the flower Clarkia breweri. Unlike many other monoterpene synthases, only a single product, (3S)-linalool, is formed. Group: Enzymes. Synonyms: LIS; Lis; 3S-linalool synthase. Enzyme Commission Number: EC 4.2.3.25. CAS No. 160477-81-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5182; S-linalool synthase; EC 4.2.3.25; 160477-81-6; LIS; Lis; 3S-linalool synthase. Cat No: EXWM-5182. Creative Enzymes
1,8-cineole synthase Requires Mn2+ or Zn2+. Mg2+ is less effective than either. 1,8-Cineole is the main product from the enzyme with just traces of other monoterpenoids. The oxygen atom is derived from water. The reaction proceeds via linalyl diphosphate and α-terpineol, the stereochemistry of both depends on the organism. However neither intermediate can substitute for geranyl diphosphate. The reaction in Salvia officinalis (sage) proceeds via (-)-(3R)-linalyl diphosphate while that in Arabidopsis (rock cress) proceeds via (+)-(3S)-linalyl diphosphate. Group: Enzymes. Synonyms: 1,8-cineole cyclase; geranyl pyrophoshate:1,8-cineole cyclase; 1,8-cineole synthetase. Enzyme Commission Number: EC 4.2.3.108. CAS No. 110637-19-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5119; 1,8-cineole synthase; EC 4.2.3.108; 110637-19-9; 1,8-cineole cyclase; geranyl pyrophoshate:1,8-cineole cyclase; 1,8-cineole synthetase. Cat No: EXWM-5119. Creative Enzymes
(-)-α-pinene synthase Cyclase II of Salvia officinalis (sage) gives about equal parts (-)-α-pinene, (-)-β-pinene and (-)-camphene, plus traces of other monoterpenoids. (3S)-Linalyl diphosphate can also be used by the enzyme in preference to (3R)-linalyl diphosphate. The 4-pro-S-hydrogen of geranyl diphosphate is lost. Requires Mg2+ (preferred to Mn2+). The enzyme from Abies grandis (grand fir) gives roughly equal parts (-)-α-pinene and (-)-β-pinene. However the clone ag11 gave 35% (-)-limonene, 24% (-)-α-pinene and 20% (-)-β-phellandrene. It requires Mn2+ and K+ (Mg2+ is ineffective). Synthase I from Pinus taeda (loblolly pine) produces (-)-α-pinene with traces...ve roughly equal proportions of (-)-α-pinene and (-)-camphene plus traces of other monoterpenoids. See also EC 4.2.3.120, (-)-β-pinene synthase; EC 4.2.3.117, (-)-camphene synthase; EC 4.2.3.16, (-)-limonene synthase; and EC 4.2.3.52, (-)-β-phellandrene synthase. Group: Enzymes. Synonyms: (-)-α-pinene/(-)-camphene synthase; (-)-α-pinene cyclase. Enzyme Commission Number: EC 4.2.3.119. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5131; (-)-α-pinene synthase; EC 4.2.3.119; (-)-α-pinene/(-)-camphene synthase; (-)-α-pinene cyclase. Cat No: EXWM-5131. Creative Enzymes
(-)-α-terpineol synthase The enzyme has been characterized from Vitis vinifera (grape). Also forms some 1,8-cineole and traces of other monoterpenoids. Group: Enzymes. Enzyme Commission Number: EC 4.2.3.111. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5123; (-)-α-terpineol synthase; EC 4.2.3.111. Cat No: EXWM-5123. Creative Enzymes
(+)-α-terpineol synthase The enzyme has been characterized from Santalum album (sandalwood). Also forms some (-)-limonene and traces of other monoterpenoids. See EC 4.2.3.16 (4S)-limonene synthase. Group: Enzymes. Enzyme Commission Number: EC 4.2.3.112. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5124; (+)-α-terpineol synthase; EC 4.2.3.112. Cat No: EXWM-5124. Creative Enzymes
(-)-β-pinene synthase Cyclase II of Salvia officinalis (sage) produces about equal parts (-)-α-pinene, (-)-β-pinene and (-)-camphene, plus traces of other monoterpenoids. The enzyme, which requires Mg2+ (preferred to Mn2+), can also use (3S)-Linalyl diphosphate (preferred to (3R)-linalyl diphosphate). The enzyme from Abies grandis (grand fir) produces roughly equal parts of (-)-α-pinene and (-)-β-pinene. Cyclase IV from Pinus contorta (lodgepole pine) produces 63% (-)-β-pinene, 26% 3-carene, and traces of α-pinene. Synthase III from Pinus taeda (loblolly pine) forms (-)-β-pinene with traces of α-pinene and requires Mn2+ and K+ (Mg2+ is ineffective). A clone...a spruce) forms 30% (-)-β-pinene and 70% (-)-α-pinene. See also EC 4.2.3.119, (-)-α-pinene synthase, EC 4.2.3.117, (-)-camphene synthase, and EC 4.2.3.107 (+)-3-carene synthase. Group: Enzymes. Synonyms: β-geraniolene synthase; (-)-(1S,5S)-pinene synthase; geranyldiphosphate diphosphate lyase (pinene forming). Enzyme Commission Number: EC 4.2.3.120. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5133; (-)-β-pinene synthase; EC 4.2.3.120; β-geraniolene synthase; (-)-(1S,5S)-pinene synthase; geranyldiphosphate diphosphate lyase (pinene forming). Cat No: EXWM-5133. Creative Enzymes
(-)-camphene synthase (-)-Camphene is the major product in Abies grandis (grand fir) with traces of other monoterpenoids. In Pseudotsuga menziesii (Douglas-fir) there are about equal parts of (-)-camphene and (-)-α-pinene with traces of four other monoterpenoids. In Solanum lycopersicum (tomato) tricyclene, β-myrcene, limonene, and traces of several other monoterpenoids are also formed. See also EC 4.2.3.15 myrcene synthase, EC 4.2.3.16 (4S)-limonene synthase, EC 4.2.3.119 (-)-α-pinene synthase and EC 4.2.3.105 tricyclene synthase. Group: Enzymes. Synonyms: CS. Enzyme Commission Number: EC 4.2.3.117. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5129; (-)-camphene synthase; EC 4.2.3.117; CS. Cat No: EXWM-5129. Creative Enzymes
γ-terpinene synthase Isolated from Thymus vulgaris (thyme), Citrus limon (lemon), Citrus unshiu (satsuma) and Origanum vulgare (oregano). Requires Mg2+. Mn2+ less effective. The reaction involves a 1,2-hydride shift. The 5-pro-S hydrogen of geranyl diphosphate is lost. Traces of several other monoterpenoids are formed in addition to γ-terpinene. Group: Enzymes. Synonyms: OvTPS2; ClcTS. Enzyme Commission Number: EC 4.2.3.114. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5126; γ-terpinene synthase; EC 4.2.3.114; OvTPS2; ClcTS. Cat No: EXWM-5126. Creative Enzymes
geranyl diphosphate diphosphatase Isolated from Ocimum basilicum (basil) and Cinnamomum tenuipile (camphor tree). Requires Mg2+ or Mn2+. Geraniol is labelled when formed in the presence of [18O]H2O. Thus mechanism involves a geranyl cation. Neryl diphosphate is hydrolysed more slowly. May be the same as EC 3.1.7.3 monoterpenyl-diphosphatase. Group: Enzymes. Synonyms: geraniol synthase; geranyl pyrophosphate pyrophosphatase; GES; CtGES. Enzyme Commission Number: EC 3.1.7.11. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3762; geranyl diphosphate diphosphatase; EC 3.1.7.11; geraniol synthase; geranyl pyrophosphate pyrophosphatase; GES; CtGES. Cat No: EXWM-3762. Creative Enzymes
(+)-sabinene synthase Isolated from Salvia officinalis (sage). The recombinant enzyme gave 63% (+)-sabinene, 21% γ-terpinene, and traces of other monoterpenoids. See EC 4.2.3.114 γ-terpinene synthase. Group: Enzymes. Synonyms: SS. Enzyme Commission Number: EC 4.2.3.110. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5122; (+)-sabinene synthase; EC 4.2.3.110; SS. Cat No: EXWM-5122. Creative Enzymes
Secologanin Secologanin, a secoiridoid glucoside, is a pivotal terpenoid intermediate in the biosynthesis of biologically active monoterpenoid indole alkaloids such as reserpine, ajmaline, and vinblastine. Secologanin synthase (cytochrome P450 isoform CYP72A1) catalyzes the oxidative cleavage of loganin into Secologanin [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 19351-63-4. Pack Sizes: 1 mg. Product ID: HY-125598. MedChemExpress MCE
secologanin synthase A heme-thiolate protein (P-450). Secologanin is the precursor of the monoterpenoid indole alkaloids and ipecac alkaloids. Group: Enzymes. Enzyme Commission Number: EC 1.3.3.9. CAS No. 258339-71-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1383; secologanin synthase; EC 1.3.3.9; 258339-71-8. Cat No: EXWM-1383. Creative Enzymes
strictosidine synthase Catalyses a Pictet-Spengler reaction between the aldehyde group of secologanin and the amino group of tryptamine. Involved in the biosynthesis of the monoterpenoid indole alkaloids. Group: Enzymes. Synonyms: strictosidine synthetase; STR; 3-α(S)-strictosidine tryptamine-lyase. Enzyme Commission Number: EC 4.3.3.2. CAS No. 69669-72-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5303; strictosidine synthase; EC 4.3.3.2; 69669-72-3; strictosidine synthetase; STR; 3-α(S)-strictosidine tryptamine-lyase. Cat No: EXWM-5303. Creative Enzymes
terpinolene synthase Requires Mg2+. Mn2+ is less effective and product ratio changes. Forms traces of other monoterpenoids. Group: Enzymes. Synonyms: ag9; PmeTPS2; LaLIMS_RR. Enzyme Commission Number: EC 4.2.3.113. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5125; terpinolene synthase; EC 4.2.3.113; ag9; PmeTPS2; LaLIMS_RR. Cat No: EXWM-5125. Creative Enzymes
tricyclene synthase The enzyme from Solanum lycopersicum (tomato) gives a mixture of tricyclene, camphene, β-myrcene, limonene, and traces of several other monoterpenoids. See EC 4.2.3.117. (-)-camphene synthase, EC 4.2.3.15, myrcene synthase and EC 4.2.3.16, (4S)-limonene synthase. Group: Enzymes. Synonyms: TPS3. Enzyme Commission Number: EC 4.2.3.105. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5116; tricyclene synthase; EC 4.2.3.105; TPS3. Cat No: EXWM-5116. Creative Enzymes

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