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| Product | Description | |
|---|---|---|
| MPC 6827 hydrochloride | MPC 6827 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 917369-31-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| MPC 6827 hydrochloride | MPC 6827 hydrochloride, the hydrochloride salt form of verubulin, inhibits of microtubule formation (IC50 = 1.5 - 3.4 nM). in vitro: inhibits polymerization of tubulin in vivo: inhibits tumor growth. Synonyms: N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine; hydrochloride; MPC-6827; MPC6827; N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine; verubulin; verubulin hydrochloride; Azixa; MPC-6827; UNII-33380QZ0QW; 917369-31-4. CAS No. 917369-31-4. Molecular formula: C17H17N3O.HCl. Mole weight: 315.8. |  |
| Verubulin | Verubulin, also known as MPC-6827, is quinazoline derivative with potential dual antineoplastic activities. Verubulin hydrochloride binds to and inhibits tubulin polymerization and interrupts microtubule formation, resulting in disruption of mitotic spindle assembly, cell cycle arrest in the G2/M phase, and cell death. This agent is not a substrate for several subtypes of multidrug resistance ABC transporters, such as P-glycoprotein, multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein 1 (BCRP1); therefore, it may be useful for treating multidrug resistant (MDR) tumors that express these transporters. In addition, as a vascular disrupting agent (VDA), MPC-6827 appears to disrupt tumor microvasculature specifically, which may result in acute ischemia and massive tumor cell death. Synonyms: MPC6827; MPC-6827; MPC 6827; MX128495; MX-128495; MX 128495; EP90745; EP-90745;EP 90745; Verubulin; trade name: Azixa. Grades: ≥98%. CAS No. 827031-83-4. Molecular formula: C21H25BrN3O9P. Mole weight: 279.34. | |
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